ID Q4SAK8_TETNG Unreviewed; 272 AA.
AC Q4SAK8;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 110.
DE SubName: Full=(spotted green pufferfish) hypothetical protein {ECO:0000313|EMBL:CAG02324.1};
DE SubName: Full=Opiate receptor-like 1 {ECO:0000313|Ensembl:ENSTNIP00000014277.1};
DE SubName: Full=Opiate receptor-like protein 1 {ECO:0000313|EMBL:ALF99991.1};
DE Flags: Fragment;
GN Name=OPRL {ECO:0000313|EMBL:ALF99991.1};
GN ORFNames=GSTENG00021405001 {ECO:0000313|EMBL:CAG02324.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|EMBL:CAG02324.1};
RN [1] {ECO:0000313|EMBL:CAG02324.1, ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|EMBL:CAG02324.1}
RP NUCLEOTIDE SEQUENCE.
RG Genoscope;
RG Whitehead Institute Centre for Genome Research;
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ALF99991.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26337547; DOI=10.1093/molbev/msv179;
RA Yun S., Furlong M., Sim M., Cho M., Park S., Cho E.B., Reyes-Alcaraz A.,
RA Hwang J.I., Kim J., Seong J.Y.;
RT "Prevertebrate Local Gene Duplication Facilitated Expansion of the
RT Neuropeptide GPCR Superfamily.";
RL Mol. Biol. Evol. 32:2803-2817(2015).
RN [4] {ECO:0000313|Ensembl:ENSTNIP00000014277.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; KT261544; ALF99991.1; -; mRNA.
DR EMBL; CAAE01014682; CAG02324.1; -; Genomic_DNA.
DR STRING; 99883.ENSTNIP00000014277; -.
DR Ensembl; ENSTNIT00000014475.1; ENSTNIP00000014277.1; ENSTNIG00000011334.1.
DR KEGG; tng:GSTEN00021405G001; -.
DR GeneTree; ENSGT00940000160661; -.
DR HOGENOM; CLU_009579_8_1_1; -.
DR OMA; MMHFFIA; -.
DR TreeFam; TF315737; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042923; F:neuropeptide binding; IEA:Ensembl.
DR GO; GO:0001626; F:nociceptin receptor activity; IEA:Ensembl.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001418; Opioid_rcpt.
DR PANTHER; PTHR24229; NEUROPEPTIDES RECEPTOR; 1.
DR PANTHER; PTHR24229:SF11; NOCICEPTIN RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00384; OPIOIDR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 19..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 148..172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 232..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..252
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CAG02324.1"
FT NON_TER 272
FT /evidence="ECO:0000313|EMBL:CAG02324.1"
SQ SEQUENCE 272 AA; 30889 MW; A4D818825182E9C0 CRC64;
LLSLCCLLRY TKMKTATNIY IFNLALADSL FLATLPFQGT DVFLGFWPFG NILCKAVVSI
DYYNMFTSTF TLTVMSIDRY VAVCHPVKAL DMRTPHKAKV VNICVWVLAS AFGVPAMVMG
NVEEEQEHNS VECIVVLPEP RGHWDPIFGT YVFLFSFLIP VAIISICYSL MVKRLRNVRI
LSGSKEKDRN LRRITRMVLV VVAVFVVCWT PIQIMVLAQS LGFNLSSLFT VVLMHFCIAL
GYVNSSLNPV LYAFLDENFK RCFREFCHPS SF
//
