ID Q4SDP0_TETNG Unreviewed; 874 AA.
AC Q4SDP0;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 24-JAN-2024, entry version 79.
DE RecName: Full=beta-mannosidase {ECO:0000256|ARBA:ARBA00012754};
DE EC=3.2.1.25 {ECO:0000256|ARBA:ARBA00012754};
DE AltName: Full=Mannanase {ECO:0000256|ARBA:ARBA00033445};
GN ORFNames=GSTENG00019942001 {ECO:0000313|EMBL:CAG01242.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|EMBL:CAG01242.1};
RN [1] {ECO:0000313|EMBL:CAG01242.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|EMBL:CAG01242.1}
RP NUCLEOTIDE SEQUENCE.
RG Genoscope;
RG Whitehead Institute Centre for Genome Research;
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal, non-reducing beta-D-mannose residues
CC in beta-D-mannosides.; EC=3.2.1.25;
CC Evidence={ECO:0000256|ARBA:ARBA00000829};
CC -!- PATHWAY: Glycan metabolism; N-glycan degradation.
CC {ECO:0000256|ARBA:ARBA00004740}.
CC -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|ARBA:ARBA00004371}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CAG01242.1}.
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DR EMBL; CAAE01014634; CAG01242.1; -; Genomic_DNA.
DR AlphaFoldDB; Q4SDP0; -.
DR KEGG; tng:GSTEN00019942G001; -.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-KW.
DR GO; GO:0004567; F:beta-mannosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR041625; Beta-mannosidase_Ig.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR041447; Mannosidase_ig.
DR PANTHER; PTHR43730; BETA-MANNOSIDASE; 1.
DR PANTHER; PTHR43730:SF1; BETA-MANNOSIDASE; 1.
DR Pfam; PF17753; Ig_mannosidase; 1.
DR Pfam; PF17786; Mannosidase_ig; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 3.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..874
FT /note="beta-mannosidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004243579"
FT DOMAIN 696..790
FT /note="Mannosidase Ig/CBM-like"
FT /evidence="ECO:0000259|Pfam:PF17786"
FT DOMAIN 794..873
FT /note="Beta-mannosidase Ig-fold"
FT /evidence="ECO:0000259|Pfam:PF17753"
SQ SEQUENCE 874 AA; 99221 MW; 091BF2619EF69F58 CRC64;
MNICVLLFVL WSFRGVLLDS LTRQQTFILS GKWTLSNANA SVSLAAEVPG CVHTALQKQG
YIQDLYFRFN DLSYRWIAYD NWTYSTIFTA SAELRAKEKV LLIFDGVDTV SSIWLNGVEV
GSTDNMFRRY DFSVGDSLKD GENELEVRFE SPVLYASQRY KAHSAYRVPP ECPPEVQKGE
CHVNFIRKEQ RSFSWDWGPS FPTMGLWKEA RLVAFDDLHL SQLSSVPLYD ANSSQWGVQV
DLILDARQAT PALIVLSVPE LHSQQSFQTR FLPGKTKTTF TLNIKASSSV RLWWPNGHGD
QPSYRLAVTG FLDGIVAFKT QSKVYFRTVE LIQDPVFGSP GLSFYFRING KSIFLKGSNW
IPAHSFQDQV APAVLWNLLQ SAVDANMNVL RVWGGGVYEQ DLFYGICDEL GIMVWQDFMF
ACAMYPTERD FIETVQRLKS HPSIIVWSGN NENEAALATD WFHIPASQKP LYLKDYVTLY
VDNIKRIVEE EDRTRPFLVS SPTNGAESEQ EGWVASNPYD PLYGDTHFYS YLPDCWDWRT
FPRARFVSEY GFQSWPSFST LRPVSVKEDW SYSSRFTSHR QHHENGNQQM LQQAALHFTL
PDSSDPIQRY TDTLYITQVM QAQCVKAQTE FYRRSRTELI DGEGLTMGAL YWQLNDIWQA
PSWASIEFGG KWKMLHYFAH DFFAAVLPVA FEDKGALHIY AVSDLSRDTA LAAVVTVHSW
ADLDSVCTLK SDRRVVPAGS AVAIFQQPVS ALLTGCGRCT RFSCLITFHL EDGNGQQGPT
NHHFFSKPKE AQGLQRPNIT AKVHEDETGY HVTLHAAAAA PFVWLDVGDI PGRFSSNGFL
MVSRNRTVTF HAWLPTSVAE LAQSLSVRSL RDVY
//