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Database: UniProt
Entry: Q4SDP0_TETNG
LinkDB: Q4SDP0_TETNG
Original site: Q4SDP0_TETNG 
ID   Q4SDP0_TETNG            Unreviewed;       874 AA.
AC   Q4SDP0;
DT   19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   19-JUL-2005, sequence version 1.
DT   24-JAN-2024, entry version 79.
DE   RecName: Full=beta-mannosidase {ECO:0000256|ARBA:ARBA00012754};
DE            EC=3.2.1.25 {ECO:0000256|ARBA:ARBA00012754};
DE   AltName: Full=Mannanase {ECO:0000256|ARBA:ARBA00033445};
GN   ORFNames=GSTENG00019942001 {ECO:0000313|EMBL:CAG01242.1};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|EMBL:CAG01242.1};
RN   [1] {ECO:0000313|EMBL:CAG01242.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA   Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA   Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA   Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA   Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA   Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA   McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA   Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA   Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA   Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT   early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|EMBL:CAG01242.1}
RP   NUCLEOTIDE SEQUENCE.
RG   Genoscope;
RG   Whitehead Institute Centre for Genome Research;
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of terminal, non-reducing beta-D-mannose residues
CC         in beta-D-mannosides.; EC=3.2.1.25;
CC         Evidence={ECO:0000256|ARBA:ARBA00000829};
CC   -!- PATHWAY: Glycan metabolism; N-glycan degradation.
CC       {ECO:0000256|ARBA:ARBA00004740}.
CC   -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|ARBA:ARBA00004371}.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC       {ECO:0000256|ARBA:ARBA00007401}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CAG01242.1}.
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DR   EMBL; CAAE01014634; CAG01242.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q4SDP0; -.
DR   KEGG; tng:GSTEN00019942G001; -.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-KW.
DR   GO; GO:0004567; F:beta-mannosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR   InterPro; IPR041625; Beta-mannosidase_Ig.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR041447; Mannosidase_ig.
DR   PANTHER; PTHR43730; BETA-MANNOSIDASE; 1.
DR   PANTHER; PTHR43730:SF1; BETA-MANNOSIDASE; 1.
DR   Pfam; PF17753; Ig_mannosidase; 1.
DR   Pfam; PF17786; Mannosidase_ig; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 3.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Lysosome {ECO:0000256|ARBA:ARBA00023228}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..874
FT                   /note="beta-mannosidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004243579"
FT   DOMAIN          696..790
FT                   /note="Mannosidase Ig/CBM-like"
FT                   /evidence="ECO:0000259|Pfam:PF17786"
FT   DOMAIN          794..873
FT                   /note="Beta-mannosidase Ig-fold"
FT                   /evidence="ECO:0000259|Pfam:PF17753"
SQ   SEQUENCE   874 AA;  99221 MW;  091BF2619EF69F58 CRC64;
     MNICVLLFVL WSFRGVLLDS LTRQQTFILS GKWTLSNANA SVSLAAEVPG CVHTALQKQG
     YIQDLYFRFN DLSYRWIAYD NWTYSTIFTA SAELRAKEKV LLIFDGVDTV SSIWLNGVEV
     GSTDNMFRRY DFSVGDSLKD GENELEVRFE SPVLYASQRY KAHSAYRVPP ECPPEVQKGE
     CHVNFIRKEQ RSFSWDWGPS FPTMGLWKEA RLVAFDDLHL SQLSSVPLYD ANSSQWGVQV
     DLILDARQAT PALIVLSVPE LHSQQSFQTR FLPGKTKTTF TLNIKASSSV RLWWPNGHGD
     QPSYRLAVTG FLDGIVAFKT QSKVYFRTVE LIQDPVFGSP GLSFYFRING KSIFLKGSNW
     IPAHSFQDQV APAVLWNLLQ SAVDANMNVL RVWGGGVYEQ DLFYGICDEL GIMVWQDFMF
     ACAMYPTERD FIETVQRLKS HPSIIVWSGN NENEAALATD WFHIPASQKP LYLKDYVTLY
     VDNIKRIVEE EDRTRPFLVS SPTNGAESEQ EGWVASNPYD PLYGDTHFYS YLPDCWDWRT
     FPRARFVSEY GFQSWPSFST LRPVSVKEDW SYSSRFTSHR QHHENGNQQM LQQAALHFTL
     PDSSDPIQRY TDTLYITQVM QAQCVKAQTE FYRRSRTELI DGEGLTMGAL YWQLNDIWQA
     PSWASIEFGG KWKMLHYFAH DFFAAVLPVA FEDKGALHIY AVSDLSRDTA LAAVVTVHSW
     ADLDSVCTLK SDRRVVPAGS AVAIFQQPVS ALLTGCGRCT RFSCLITFHL EDGNGQQGPT
     NHHFFSKPKE AQGLQRPNIT AKVHEDETGY HVTLHAAAAA PFVWLDVGDI PGRFSSNGFL
     MVSRNRTVTF HAWLPTSVAE LAQSLSVRSL RDVY
//
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