ID Q4SEN6_TETNG Unreviewed; 1284 AA.
AC Q4SEN6;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE SubName: Full=Chromosome undetermined SCAF14615, whole genome shotgun sequence {ECO:0000313|EMBL:CAG00896.1};
DE Flags: Fragment;
GN ORFNames=GSTENG00019466001 {ECO:0000313|EMBL:CAG00896.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|EMBL:CAG00896.1};
RN [1] {ECO:0000313|EMBL:CAG00896.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|EMBL:CAG00896.1}
RP NUCLEOTIDE SEQUENCE.
RG Genoscope;
RG Whitehead Institute Centre for Genome Research;
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; CAAE01014615; CAG00896.1; -; Genomic_DNA.
DR KEGG; tng:GSTEN00019466G001; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR InterPro; IPR015212; RGS-like_dom.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR PANTHER; PTHR45872:SF3; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12; 1.
DR PANTHER; PTHR45872; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF09128; RGS-like; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 6..51
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 714..912
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 142..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 190..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 507..614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1099..1126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1148..1203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..614
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1099..1120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1150..1165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CAG00896.1"
SQ SEQUENCE 1284 AA; 142935 MW; 9E8AE8835E762635 CRC64;
GLVQRCVIIQ RDKNGFGLTV SGDNPVFVQL VKKNGAAMRA GVQKGDRIIK VRILCVQRPP
GSAPPLPPSA GACWLQVNGT LVTRSNHMEV VQLIKSGSYV ALTVLGRPPG LPLQGEDGLE
DTDVMEEGEL CSCLPTSPEL SARQQRSLES AGFQDDQITY GSAEGSEDRT SHSQKADLIQ
KMLNQEHHVL QVPVSSSQTV TTQDGAMRSR SSETEDGAAG APPREQTSTL GADSCSDDTT
KACSEASVQA PGPPYPLNPQ IIGAEDDYFD SQQEQINGEC SSFQSVDLLK SRPAHLAVFL
HHVISQFDPA PVLCYLYADM HKLATSKESR RFFMEFHSLF LDRTARNAGW SCSRRICADR
SRRRCRKRCC RTCTNIWRIS GHRVGLELSR LPFSEVHPPS LVCVTWLCRQ KRSMGLTLAE
DELSRLDSEP GKELSDRECS CAEHILSKIE DILSASQPTE EEKCQTTQYV ILTYMKYLGV
KVKEPRGLEH KRARINFLPK IKKSIKPEKE GEEKVKKPRF HNILNPPRRL SRVDSTSVGK
AVELNKQRSP KHLSPPAEQT DAAAASAGRL SGNQPSEGSD TSSQFSPSTT SPTHSTPTPQ
GSDTSGQDSD PNMSPFCIQL RMAEALQPGD HQEGASSPAC TQFDFSPTNL EQLQEDDQET
FSSTRMEVQC SVSPAEVHSE DDQVCEMECE EDRQNWQSLV SPGVLASLTP QEIKRQEVIN
ELFYTERAHL RTLKVLDSVF HQRLKADAIL PPEDIRLIFT NLEEIIQLHV SVSEQMLVIR
KRNETSVIGQ IADDLLAWVS TITHHHVQDG KEEKIKSAVG AFCSNLPSAL ELIKSKKKKD
QRFSLFMQAA ERNRLCRRLQ LKDILPVEML RFTKYPLLLD NIAKYTEGDE EREKVNKAAE
CCKKILYHVN QAVKEAENRR RLMDYQRRLD ISSLKQSENP IILELKNLDL TARTMVHEGP
LSWRVNKDKR IELYAILLED ILVLLQKQDE RLILKFHGKN QASAADAKNI FSPVIKLSTV
LVRPVATGEP ARSPRQGSSI RVELHLCLQR VCVSDNKSFF VLSMSENGAQ IYKLTAQSVS
DQRTAAGDAI DIIKQDMTKM SSNPSSPLSG SDQEQNPEPN PFFELPSKGE EALRTLATLK
QALLSHMLRN PNPLGSSQGP LADPDSQKSH LQVPPEHPGT PEGNGEILLP EFAGGSQDSN
ADEDMEVEGD IDMRRLLSSA QMGGDGSGPD LSRQLMTHLR LLQADLQYLK VRPAQEPHWS
SVDVYSARAD FWNVTWWKGS RGPT
//
