ID Q4SKR0_TETNG Unreviewed; 960 AA.
AC Q4SKR0;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=ribonuclease H {ECO:0000256|ARBA:ARBA00012180};
DE EC=3.1.26.4 {ECO:0000256|ARBA:ARBA00012180};
GN ORFNames=GSTENG00016596001 {ECO:0000313|EMBL:CAF98772.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|EMBL:CAF98772.1};
RN [1] {ECO:0000313|EMBL:CAF98772.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|EMBL:CAF98772.1}
RP NUCLEOTIDE SEQUENCE.
RG Genoscope;
RG Whitehead Institute Centre for Genome Research;
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the beta type-B retroviral polymerase family.
CC HERV class-II K(HML-2) pol subfamily. {ECO:0000256|ARBA:ARBA00010879}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CAF98772.1}.
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DR EMBL; CAAE01014565; CAF98772.1; -; Genomic_DNA.
DR AlphaFoldDB; Q4SKR0; -.
DR KEGG; tng:GSTEN00016596G001; -.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041577; RT_RNaseH_2.
DR PANTHER; PTHR37984:SF7; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF17919; RT_RNaseH_2; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
PE 3: Inferred from homology;
FT DOMAIN 660..821
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
SQ SEQUENCE 960 AA; 105847 MW; B6BDE0755FEFA713 CRC64;
MSPRHTQPSS VIASVKLPDF WLSDPAPWFQ HVEALFHLRG VTEDDSKYYL VVAALDQQST
RRVMQLLRDP PPRGKYAALK ELLLRRFGLS AAERADKLLS LPGLGDGSAV DLMDSMLSLL
GSDEGGFLFP HIFLRQLPHP VRAALANSPS LAAGDFRGLA EEADRVLLTA RRTSVRSVLA
DPQLLVSEDP DQDFSIRLAG ATIFSKVDLV RGYHQVPVRA EDVPKTAVIT PFGLFEFLRM
PFGLKGAAQT FQRLMDSVLR GLTFVFVNLD DILVASPSAD EHLTHLGQVF QRLADHGLIV
NPAKCQFGLQ VIDFLGHRIS SEGAVPLPAK VQVVAEFPRP ASVKALQEFL GMVNFYNRFL
PRAAHLLQPL YEALRLKKAT DQVDWTAERV QAFEGAKSAL ANATLLAHPA PRADIALTTD
ASDVAVGAVV EQGVGGVWQP LAFFSRKLRD NERKYSVFDR ELLALYLATR HFRFLLEGRS
FTAYVDHKPL TFAMSKVSEP WSARQQRHLA AVSEFTTDIR HVAGKANPVA DCLSRVLVCP
VYLGLDFASM AADQSGDQEI RALESAGTGL KLEKAVVQDG GPTLLCDVST GRPRPVVPGT
WRRRVFDMVH SLSHPGVRAS VKLVSAKFVW PGLRKEVREW AAACVACQRA KVHQHTKAPL
EPFPIPARRF DHVHVDLVGP LPPSHGYTHL LTMVDRTTRW PEVVPLSSTT SADVARAFLS
VWVARFGSPS DITSDRGPQF VSELWSSMAR SLGTQVHRTT AYHPQANGLC ERFHRSLKAA
LRAALSDDSW VDRLPWVMLG LRSAPKEDLG ASPAELVLGQ PLRVPGEFLP ESAPPDLLTA
RFVFVRHDAH RSPLRPPYDG PFRVLETGTK SFMLDMGGRA ERVTLDRLKP AHLLAGQDVL
LAQVPRRGRP PKVQNIPPND LSSDLQPAVD LVSPACGSSA FPEEGRRSRY GRLIKAPFRD
//
