ID Q4SZM3_TETNG Unreviewed; 933 AA.
AC Q4SZM3;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE RecName: Full=isoleucine--tRNA ligase {ECO:0000256|ARBA:ARBA00013165};
DE EC=6.1.1.5 {ECO:0000256|ARBA:ARBA00013165};
DE AltName: Full=Isoleucyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00032665};
DE Flags: Fragment;
GN ORFNames=GSTENG00009778001 {ECO:0000313|EMBL:CAF93909.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|EMBL:CAF93909.1};
RN [1] {ECO:0000313|EMBL:CAF93909.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|EMBL:CAF93909.1}
RP NUCLEOTIDE SEQUENCE.
RG Genoscope;
RG Whitehead Institute Centre for Genome Research;
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363035}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CAF93909.1}.
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DR EMBL; CAAE01011581; CAF93909.1; -; Genomic_DNA.
DR AlphaFoldDB; Q4SZM3; -.
DR KEGG; tng:GSTEN00009778G001; -.
DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004822; F:isoleucine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006428; P:isoleucyl-tRNA aminoacylation; IEA:InterPro.
DR Gene3D; 1.10.730.20; -; 2.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR Gene3D; 1.10.10.830; Ile-tRNA synthetase CP2 domain-like; 1.
DR Gene3D; 3.90.740.10; Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain; 1.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR002300; aa-tRNA-synth_Ia.
DR InterPro; IPR002301; Ile-tRNA-ligase.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR NCBIfam; TIGR00392; ileS; 1.
DR PANTHER; PTHR42765:SF1; ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR42765; SOLEUCYL-TRNA SYNTHETASE; 1.
DR Pfam; PF00133; tRNA-synt_1; 1.
DR PRINTS; PR00984; TRNASYNTHILE.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363035};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363035};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363035};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363035};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363035}.
FT DOMAIN 38..648
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CAF93909.1"
FT NON_TER 933
FT /evidence="ECO:0000313|EMBL:CAF93909.1"
SQ SEQUENCE 933 AA; 103793 MW; AD3647AF2A0F8F99 CRC64;
YRDTVLVPRT DFPMKVTGQK LLDQEVAIQK KCGFADLYAW QRSRKAKKEF CVHDGPPYAN
GDPHVGHALN KILKDIRNRF EMLKGRRVHY IPGWDCHGLP IELKALGELT PSSLTPLQIR
QKARAFAEEA ITRQKAAFQR WGVMADWDHC YYTHHGVYEA AQLKVFQEMH GKGFIYQDHK
PVFWSPSSRT ALAEAELEYN PDHVSRAIYA TFPLTTVPAN IASEVGLDNV SVLVWTTQPW
TIPANQAVCY MPKAQYSVVK RTDSSQMLLI AAERTASLAS LLGTELETVG TFTGSQLEGG
ICKHPVIPDK FVQLLPANHV TMAKGTGLVH TAPAHGMDDY SVASHFNLPV ECMVDEDGKF
TELAGPELHN LAVMTEGTDK VISMLKDCGA LVNEERCVHS YPYDWRTKQP VIIRPSRQWF
IDTASLKDKA KEALKKVHIL PESARGSLLA MLDRRTYWCI SRQRSWGVPI PVFYHRETGE
PLLNKYTMSH ITSLFKEKGS DCWWELPLET LLPEEVLEKS KAGPAIDYVR GEDVLDIWFD
SGTSWAAVLE ETGCMADAYL EGKDQIGGWF QSSLLTSVAV RNKAPYRSLV VHGFVVGEKG
EKMSKSVGNV VDPDEVINGG KDTATTAYGA DVLRWWVAES NVFSEVQIGA NVLNSARDDI
NKVPRSSSAY CLVNDVFIGL GSCWRHMTDH FLQLRNSLRF LLGNLQGFDP QVQATEPADM
HYIDQYMLHL LHKYSIKVTD AYSEFGILAG SSVSFKPSSP VTFPVFISAS SKIGHKETQT
LFKSGWIQST SVWLRPGVEE MVEGACAIRD SFLSSIPGKN PAKYDLTIAI KPGLLFELME
CLQGEATSTS SQLAELMMVA RVDLTSELPV DLPPDALLSH GTFLINLEGG VIRENSAYAI
AAVPTSGSRC PRCRRHTAET ADALCPRCRT VLQ
//
