ID Q4TTA0_CAEEL Unreviewed; 291 AA.
AC Q4TTA0;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 119.
DE SubName: Full=Sulfotransferase domain-containing protein {ECO:0000313|EMBL:CCD61857.1};
GN Name=hst-3.2 {ECO:0000313|EMBL:CCD61857.1,
GN ECO:0000313|WormBase:F52B10.2};
GN ORFNames=CELE_F52B10.2 {ECO:0000313|EMBL:CCD61857.1}, F52B10.2
GN {ECO:0000313|WormBase:F52B10.2};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD61857.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD61857.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD61857.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bristol N2;
RG WormBase Consortium;
RA WormBase;
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; BX284606; CCD61857.1; -; Genomic_DNA.
DR RefSeq; NP_001024698.1; NM_001029527.1.
DR AlphaFoldDB; Q4TTA0; -.
DR SMR; Q4TTA0; -.
DR STRING; 6239.F52B10.2.1; -.
DR PaxDb; 6239-F52B10-2; -.
DR EnsemblMetazoa; F52B10.2.1; F52B10.2.1; WBGene00044303.
DR GeneID; 3564879; -.
DR KEGG; cel:CELE_F52B10.2; -.
DR UCSC; F52B10.2; c. elegans.
DR AGR; WB:WBGene00044303; -.
DR WormBase; F52B10.2; CE38605; WBGene00044303; hst-3.2.
DR eggNOG; KOG3704; Eukaryota.
DR GeneTree; ENSGT00940000154768; -.
DR HOGENOM; CLU_017703_0_0_1; -.
DR InParanoid; Q4TTA0; -.
DR OMA; YFHSKMA; -.
DR OrthoDB; 10019at2759; -.
DR PhylomeDB; Q4TTA0; -.
DR Reactome; R-CEL-2022928; HS-GAG biosynthesis.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00044303; Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues.
DR GO; GO:0005796; C:Golgi lumen; IC:WormBase.
DR GO; GO:0008467; F:[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity; ISS:WormBase.
DR GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IGI:WormBase.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR037359; NST/OST.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR PANTHER; PTHR10605:SF73; HEPARAN SULFATE 3-O SULFOTRANSFERASE-B, ISOFORM A; 1.
DR PANTHER; PTHR10605; HEPARAN SULFATE SULFOTRANSFERASE; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR637359-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..291
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004244511"
FT DOMAIN 29..275
FT /note="Sulfotransferase"
FT /evidence="ECO:0000259|Pfam:PF00685"
FT ACT_SITE 38
FT /note="For sulfotransferase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-1"
FT BINDING 38..42
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 119
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 127
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT BINDING 255..259
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-2"
FT DISULFID 240..250
FT /evidence="ECO:0000256|PIRSR:PIRSR637359-3"
SQ SEQUENCE 291 AA; 33392 MW; 0745E4E15FE13DF2 CRC64;
MKYRLLLILH LIDLISCGVI PNTSKKRFPD AIIVGVKKSG TRALLEFLRV NPLIKAPGPE
VHFFDKNFNK GLEWYREQMP ETKFGEVTIE KSPAYFHSKM APERIKSLNP NTKIIIVVRD
PVTRAISDYT QSSSKRKRVG LMPSFETMAV GNCANWLRTN CTTKTRGVNA GWGAIRIGVY
HKHMKRWLDH FPIENIHIVD GEKLISNPAD EISATEKFLG LKPVAKPEKF GVDPIKKFPC
IKNEDGKLHC LGKTKGRHHP DVEPSVLKTL REFYGPENKK FYQMINHWFD W
//
