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Database: UniProt
Entry: Q4U4D2
LinkDB: Q4U4D2
Original site: Q4U4D2 
ID   OPN4_PODSI              Reviewed;         475 AA.
AC   Q4U4D2;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 2.
DT   01-OCT-2014, entry version 39.
DE   RecName: Full=Melanopsin;
DE   AltName: Full=Opsin-4;
GN   Name=OPN4;
OS   Podarcis sicula (Italian wall lizard).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Laterata;
OC   Lacertibaenia; Lacertidae; Podarcis.
OX   NCBI_TaxID=65484;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAY34941.2}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=16688437; DOI=10.1007/s00114-006-0119-9;
RA   Frigato E., Vallone D., Bertolucci C., Foulkes N.S.;
RT   "Isolation and characterization of melanopsin and pinopsin expression
RT   within photoreceptive sites of reptiles.";
RL   Naturwissenschaften 93:379-385(2006).
CC   -!- FUNCTION: Photoreceptor implicated in non-image-forming responses
CC       to light. May be able to isomerize covalently bound all-trans
CC       retinal back to 11-cis retinal (By similarity).
CC       {ECO:0000250|UniProtKB:Q9QXZ9}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Highest level in the lateral eye. Low level in
CC       the brain. {ECO:0000269|PubMed:16688437}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       Opsin subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; DQ013043; AAY34941.2; -; mRNA.
DR   ProteinModelPortal; Q4U4D2; -.
DR   HOVERGEN; HBG007871; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0009881; F:photoreceptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007602; P:phototransduction; IEA:UniProtKB-KW.
DR   GO; GO:0018298; P:protein-chromophore linkage; IEA:UniProtKB-KW.
DR   GO; GO:0007601; P:visual perception; IEA:InterPro.
DR   Gene3D; 1.20.1070.10; -; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR001760; Opsin.
DR   InterPro; IPR027430; Retinal_BS.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00238; OPSIN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   PROSITE; PS00238; OPSIN; 1.
PE   2: Evidence at transcript level;
KW   Chromophore; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Photoreceptor protein; Receptor; Retinal protein;
KW   Sensory transduction; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN         1    475       Melanopsin.
FT                                /FTId=PRO_0000271893.
FT   TOPO_DOM      1     21       Extracellular. {ECO:0000255}.
FT   TRANSMEM     22     42       Helical; Name=1. {ECO:0000255}.
FT   TOPO_DOM     43     53       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     54     74       Helical; Name=2. {ECO:0000255}.
FT   TOPO_DOM     75     90       Extracellular. {ECO:0000255}.
FT   TRANSMEM     91    111       Helical; Name=3. {ECO:0000255}.
FT   TOPO_DOM    112    134       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    135    155       Helical; Name=4. {ECO:0000255}.
FT   TOPO_DOM    156    187       Extracellular. {ECO:0000255}.
FT   TRANSMEM    188    208       Helical; Name=5. {ECO:0000255}.
FT   TOPO_DOM    209    240       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    241    261       Helical; Name=6. {ECO:0000255}.
FT   TOPO_DOM    262    276       Extracellular. {ECO:0000255}.
FT   TRANSMEM    277    297       Helical; Name=7. {ECO:0000255}.
FT   TOPO_DOM    298    475       Cytoplasmic. {ECO:0000255}.
FT   MOD_RES     284    284       N6-(retinylidene)lysine. {ECO:0000250}.
FT   CARBOHYD    178    178       N-linked (GlcNAc...). {ECO:0000255}.
FT   DISULFID     89    167       {ECO:0000255|PROSITE-ProRule:PRU00521}.
SQ   SEQUENCE   475 AA;  53068 MW;  6382B0BC171B7D16 CRC64;
     MGTQHRIKVD VPDRVLYTVG SCVLVIGSIG ITGNLLVLYA FYSNKRLRTP ANYFIMNLAA
     SDFLMSATQA PICFLNSMHT EWILGDIGCN FYVFCGALFG ITSMMTLLAI SVDRYCVITK
     PLQSIKRSSK KRSCIIIAFV WLYSLGWSVC PLFGWSSYIP EGLMISCTWD YVSYSPANRS
     YTMMLCCFVF FIPLIIIFHC YLFMFLAIRS TGRNVQKLGS TYNRKSNVSQ SVKSEWKLAK
     IAFVAIVVFV LSWSPYACVT LIAWAGYAKT LNPYSKSVPA VIAKASAIYN PIIYAIIHPR
     YRRTIRSAVP CLRFLIRISP SDLSTSSVNE SSFRASMSSR HSFAARNKSS CVSSISAAET
     TWSDMELEPV EAARKKQQPH RSRSFSKQAE EETGLLLKTQ SCNVLTGEKV AVSSISLHDP
     FERSFGENAP ELLLRPSCLR TSSLPFGLNS SSTEENADTS DMEVQEQHQM EASSH
//
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