ID   Q4UB07_THEAN            Unreviewed;       878 AA.
AC   Q4UB07;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   27-MAR-2024, entry version 91.
DE   SubName: Full=Histone deacetylase family protein, putative {ECO:0000313|EMBL:CAI75994.1};
GN   ORFNames=TA18230 {ECO:0000313|EMBL:CAI75994.1};
OS   Theileria annulata.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC   Theileriidae; Theileria.
OX   NCBI_TaxID=5874 {ECO:0000313|EMBL:CAI75994.1, ECO:0000313|Proteomes:UP000001950};
RN   [1] {ECO:0000313|EMBL:CAI75994.1, ECO:0000313|Proteomes:UP000001950}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ankara {ECO:0000313|Proteomes:UP000001950};
RX   PubMed=15994557; DOI=10.1126/science.1110418;
RA   Pain A., Renauld H., Berriman M., Murphy L., Yeats C.A., Weir W.,
RA   Kerhornou A., Aslett M., Bishop R., Bouchier C., Cochet M., Coulson R.M.R.,
RA   Cronin A., de Villiers E.P., Fraser A., Fosker N., Gardner M., Goble A.,
RA   Griffiths-Jones S., Harris D.E., Katzer F., Larke N., Lord A., Maser P.,
RA   McKellar S., Mooney P., Morton F., Nene V., O'Neil S., Price C.,
RA   Quail M.A., Rabbinowitsch E., Rawlings N.D., Rutter S., Saunders D.,
RA   Seeger K., Shah T., Squares R., Squares S., Tivey A., Walker A.R.,
RA   Woodward J., Dobbelaere D.A.E., Langsley G., Rajandream M.A., McKeever D.,
RA   Shiels B., Tait A., Barrell B.G., Hall N.;
RT   "Genome of the host-cell transforming parasite Theileria annulata compared
RT   with T. parva.";
RL   Science 309:131-133(2005).
CC   -!- SIMILARITY: Belongs to the inositol phosphokinase (IPK) family.
CC       {ECO:0000256|ARBA:ARBA00007374}.
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DR   EMBL; CR940352; CAI75994.1; -; Genomic_DNA.
DR   RefSeq; XP_955470.1; XM_950377.1.
DR   AlphaFoldDB; Q4UB07; -.
DR   STRING; 5874.Q4UB07; -.
DR   GeneID; 3865044; -.
DR   KEGG; tan:TA18230; -.
DR   VEuPathDB; PiroplasmaDB:TA18230; -.
DR   eggNOG; KOG1343; Eukaryota.
DR   eggNOG; KOG1620; Eukaryota.
DR   InParanoid; Q4UB07; -.
DR   OMA; DKMMGFC; -.
DR   OrthoDB; 124800at2759; -.
DR   Proteomes; UP000001950; Chromosome 3.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016301; F:kinase activity; IEA:InterPro.
DR   GO; GO:0032958; P:inositol phosphate biosynthetic process; IEA:InterPro.
DR   CDD; cd09992; HDAC_classII; 1.
DR   Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR   Gene3D; 3.30.470.160; Inositol polyphosphate kinase; 1.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR005522; IPK.
DR   InterPro; IPR038286; IPK_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   PANTHER; PTHR10625:SF4; HISTONE DEACETYLASE 6, ISOFORM G; 1.
DR   PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR   Pfam; PF00850; Hist_deacetyl; 1.
DR   Pfam; PF03770; IPK; 1.
DR   PRINTS; PR01270; HDASUPER.
DR   SUPFAM; SSF52768; Arginase/deacetylase; 1.
DR   SUPFAM; SSF56104; SAICAR synthase-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001950};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          35..406
FT                   /note="Histone deacetylase"
FT                   /evidence="ECO:0000259|Pfam:PF00850"
FT   REGION          162..181
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   878 AA;  100414 MW;  51DF5F8E94978E6A CRC64;
     MSKISELNHT KKLVAVSYDE EHMASTYHDD MDQYHVESHK RLSSILERLK EAKISLEFEH
     ESNLIDQLYH VKPRPVFRQI LMLCHTEKYL DQVTFWTNKL SELNSSSESK NGNKSSENYL
     SLFPLDVDTY MTPKSELVAN LAVGSLIELC NIIMKSTVSN TKTETQIKNE PNSDSDSSQY
     TEAELNNNHD LKVKKNDISS NNSDLGKGFA LVRPPGHHAT PDKMMGFCIY NNVAIAARYL
     QHKFGLKRVA IVDWDVHHGN GTQDIFYDDN SVCFISLHRY GDNEDSFYPY TGYCDEIGVG
     KGYGYNVNIP LEKSFTNADL VHSFNKVVIP VLELFEPEFI IVSAGFDSGI DDLLGGCNLD
     WDGFSWATFK LCQLAEKYSN GRLLLSLEGG YTLSRLSEDV ESVLSTLVKY EHSFYDSSVH
     KTIKIAPELD DEGVFESTAS MCKNICHLLD LYDLAKDLQD LTLLTKSERK LDENSQINND
     TTCYSSESSF RDDINDEYPS PYDESEVNFF QYPYELDDNT LVLAAGHRNQ WFLPTNGKND
     QVIKLCSKKE IDFFIWLYKQ NKVPLKVYNQ PVEEFKLQFS NGPQNVVRSG IRLTNRIKHI
     YDTNYVSSVN IDKGSKTTLN NETDYNNIET LKETLGQNLN HTCAIPVSEN EKDGKAETKG
     WAMSLKIIDY IAECTGIFEK FVFENWKLGK TCAIRLKNVI YGMKLPCVMD LKMGTRLYGD
     DCFDPKVIEF KESKAKVRSC KTHGFSVSGM FKWNRVTNIA EFVPQHVVNN SRTDDEIAKL
     FTLYFSVVDD KDYKRVISNK FVEKLENLKM IFESQTNLAL YGSSLLFVYD AKEKSDKNDV
     FLIDLSHVSY NVRSLDHGFL LGLNSILRIL KLTQEQFE
//