ID   Q4UEN3_THEAN            Unreviewed;       903 AA.
AC   Q4UEN3;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   27-MAR-2024, entry version 116.
DE   RecName: Full=DNA replication licensing factor MCM2 {ECO:0000256|ARBA:ARBA00018925};
DE            EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN   ORFNames=TA13680 {ECO:0000313|EMBL:CAI74456.1};
OS   Theileria annulata.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC   Theileriidae; Theileria.
OX   NCBI_TaxID=5874 {ECO:0000313|EMBL:CAI74456.1, ECO:0000313|Proteomes:UP000001950};
RN   [1] {ECO:0000313|EMBL:CAI74456.1, ECO:0000313|Proteomes:UP000001950}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ankara {ECO:0000313|Proteomes:UP000001950};
RX   PubMed=15994557; DOI=10.1126/science.1110418;
RA   Pain A., Renauld H., Berriman M., Murphy L., Yeats C.A., Weir W.,
RA   Kerhornou A., Aslett M., Bishop R., Bouchier C., Cochet M., Coulson R.M.R.,
RA   Cronin A., de Villiers E.P., Fraser A., Fosker N., Gardner M., Goble A.,
RA   Griffiths-Jones S., Harris D.E., Katzer F., Larke N., Lord A., Maser P.,
RA   McKellar S., Mooney P., Morton F., Nene V., O'Neil S., Price C.,
RA   Quail M.A., Rabbinowitsch E., Rawlings N.D., Rutter S., Saunders D.,
RA   Seeger K., Shah T., Squares R., Squares S., Tivey A., Walker A.R.,
RA   Woodward J., Dobbelaere D.A.E., Langsley G., Rajandream M.A., McKeever D.,
RA   Shiels B., Tait A., Barrell B.G., Hall N.;
RT   "Genome of the host-cell transforming parasite Theileria annulata compared
RT   with T. parva.";
RL   Science 309:131-133(2005).
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DR   EMBL; CR940348; CAI74456.1; -; Genomic_DNA.
DR   RefSeq; XP_952188.1; XM_947095.1.
DR   AlphaFoldDB; Q4UEN3; -.
DR   STRING; 5874.Q4UEN3; -.
DR   GeneID; 3861832; -.
DR   KEGG; tan:TA13680; -.
DR   VEuPathDB; PiroplasmaDB:TA13680; -.
DR   eggNOG; KOG0477; Eukaryota.
DR   InParanoid; Q4UEN3; -.
DR   OMA; LKDWPYS; -.
DR   OrthoDB; 5476523at2759; -.
DR   Proteomes; UP000001950; Chromosome 2.
DR   GO; GO:0042555; C:MCM complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   Gene3D; 2.20.28.10; -; 1.
DR   Gene3D; 3.30.1640.10; mini-chromosome maintenance (MCM) complex, chain A, domain 1; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR031327; MCM.
DR   InterPro; IPR008045; MCM2.
DR   InterPro; IPR001208; MCM_dom.
DR   InterPro; IPR041562; MCM_lid.
DR   InterPro; IPR027925; MCM_N.
DR   InterPro; IPR033762; MCM_OB.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR   PANTHER; PTHR11630:SF44; DNA REPLICATION LICENSING FACTOR MCM2; 1.
DR   Pfam; PF00493; MCM; 1.
DR   Pfam; PF17855; MCM_lid; 1.
DR   Pfam; PF14551; MCM_N; 1.
DR   Pfam; PF17207; MCM_OB; 1.
DR   PRINTS; PR01657; MCMFAMILY.
DR   PRINTS; PR01658; MCMPROTEIN2.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00350; MCM; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS50051; MCM_2; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001950}.
FT   DOMAIN          424..650
FT                   /note="MCM"
FT                   /evidence="ECO:0000259|PROSITE:PS50051"
SQ   SEQUENCE   903 AA;  102982 MW;  BAED03C1311620F5 CRC64;
     MQGFAKLGIE NVDEYEQDML DDAVYELDPK DRRAAERRMR FRDRARTRGT EGDRAMHKQL
     WRKILDMADE EFEDNLFARI SERVTKRRTD FATAEAEAPD ISRLESAKAV LHSNPNEVTF
     DEKYQQAIDS CFRYFLYRFK LSDDAPNYYY KSKISTMIRE DKTVLRVAAQ HLLQFHCENV
     ITWLEFRPSD VLPVLHDCLT FEVSKLKEEL YKKRYCKVAI TDWPFTTQLG LLRSSELNTL
     IRVSGIKVTM PLAILINIIG IVIRRGSVLP RLRVLYLKCN SCDNTLSELP IYFSDTIKPV
     FPKRCPYCRS PGFTVDRINT EYTDYQKLTI QEPPSSVPAG RTPRQKIVIL TGDFVDSVKP
     GDLVDVLGTY KTRYDLGLNI KHGFPILHTE LEANNIERQE DSLSFELTEE DISEIKRLSR
     DPCIRERLIA SVAPTLWGHK TAKASVLCAL FGGVPKGILS TLNSANTGSG AGGHRIRGDI
     NVLLVGDPGL GKSQLLQYVH KTANRSVLTT GKGASAVGLT AGVRKDPITG TLRHNFVREW
     CLEGGALVLA DEGFCVIDEF DKMTDKDRVS IHEAMEQQSI SISKAGIVTS LRARCSVIAA
     ANPKFGRYEP ALTFKENVDF SDPILSRFDL IVVLRDIPNI EEDLLLSEYV VTNHQLLHPR
     LDNVEDYENV LKRLQNTLLS SNIVEPISTD LFKKYVYYAR KNIKPMIGQE YYSQIEGKLS
     GVYSRIRQRT FGGGYPLTLR HIESIIRISE ANAKMRLSNV ITSEDVDVAI AMLLESYISS
     QKYSVATRLS MEFTRYRALF TGNDELLTQL LKGSLQHQLQ VQLRKQYVNQ MHHTDGTDVD
     MENMENIVGM ESNISVMLFI KICNRYKFGE DQVNRWMHSS QFKKHFKLYH DQNGNQLITS
     TLT
//