ID Q4UH91_THEAN Unreviewed; 536 AA.
AC Q4UH91;
DT 05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Choline kinase, putative {ECO:0000313|EMBL:CAI73548.1};
DE EC=2.7.1.32 {ECO:0000313|EMBL:CAI73548.1};
GN ORFNames=TA20330 {ECO:0000313|EMBL:CAI73548.1};
OS Theileria annulata.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Theileriidae; Theileria.
OX NCBI_TaxID=5874 {ECO:0000313|EMBL:CAI73548.1, ECO:0000313|Proteomes:UP000001950};
RN [1] {ECO:0000313|EMBL:CAI73548.1, ECO:0000313|Proteomes:UP000001950}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ankara {ECO:0000313|Proteomes:UP000001950};
RX PubMed=15994557; DOI=10.1126/science.1110418;
RA Pain A., Renauld H., Berriman M., Murphy L., Yeats C.A., Weir W.,
RA Kerhornou A., Aslett M., Bishop R., Bouchier C., Cochet M., Coulson R.M.R.,
RA Cronin A., de Villiers E.P., Fraser A., Fosker N., Gardner M., Goble A.,
RA Griffiths-Jones S., Harris D.E., Katzer F., Larke N., Lord A., Maser P.,
RA McKellar S., Mooney P., Morton F., Nene V., O'Neil S., Price C.,
RA Quail M.A., Rabbinowitsch E., Rawlings N.D., Rutter S., Saunders D.,
RA Seeger K., Shah T., Squares R., Squares S., Tivey A., Walker A.R.,
RA Woodward J., Dobbelaere D.A.E., Langsley G., Rajandream M.A., McKeever D.,
RA Shiels B., Tait A., Barrell B.G., Hall N.;
RT "Genome of the host-cell transforming parasite Theileria annulata compared
RT with T. parva.";
RL Science 309:131-133(2005).
CC -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC -!- PATHWAY: Phospholipid metabolism. {ECO:0000256|ARBA:ARBA00025707}.
CC -!- SIMILARITY: Belongs to the choline/ethanolamine kinase family.
CC {ECO:0000256|ARBA:ARBA00038211}.
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DR EMBL; CR940347; CAI73548.1; -; Genomic_DNA.
DR RefSeq; XP_954225.1; XM_949132.1.
DR AlphaFoldDB; Q4UH91; -.
DR STRING; 5874.Q4UH91; -.
DR GeneID; 3863664; -.
DR KEGG; tan:TA20330; -.
DR VEuPathDB; PiroplasmaDB:TA20330; -.
DR eggNOG; KOG2686; Eukaryota.
DR InParanoid; Q4UH91; -.
DR OrthoDB; 144299at2759; -.
DR Proteomes; UP000001950; Chromosome 1 part 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004103; F:choline kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.90.1200.10; -; 2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR PANTHER; PTHR22603; CHOLINE/ETHANOALAMINE KINASE; 1.
DR PANTHER; PTHR22603:SF93; RE24176P; 1.
DR Pfam; PF01633; Choline_kinase; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:CAI73548.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001950};
KW Transferase {ECO:0000313|EMBL:CAI73548.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 514..534
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 235..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 375..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 536 AA; 60386 MW; ABF3CB555F79305E CRC64;
MRLEIFDEDI YKKILVPNAS RNTSYIERIE DSYELKLLCK KYVPFWSELD LSDIEINLIT
IALTNKVYMV RVVNGDPNSI CLDKVLLRII DEDKSILYDI EHQNDVFKLL SEYGFCPKMI
NKFPGGRIEN WIEGFVLHSN NLFNLSVLTS IATLLAKLHK IITKVAPKNW DRTPSLIYKT
EEWIPKCHYI NQYYNLNINL YEIDQLFLQY KSFLTKYIEY YTVTVSPVTV LGQTASNGPT
MSSTNSTKDI SSTEVGTDSS KDIGAVGAST VTGSGTTDSN KENTSTNNLT TTKDSTDTKV
NSTNSSTKDI DTIGASTVTE GKGANFTLTE CNRERELNNT FSTSGKGANS MPMECTSEKI
LNEIAVVTNS RESSTFSNTG VSTSKDSNSK GDTKGVGEEV GCHDTDPVTN IGREYGMKIV
FCHNDMHIKN FIATYDGLTL IDFDYSSFNY VGADIGYFFI ESNFDYDCDE YPFFKLDRSL
ELSYELKTMF ASVYLSESLG FNVLPNHLNI IDPFLETIEL FSIGTLIFWA YWGIIM
//
