ID Q4UHR0_THEAN Unreviewed; 770 AA.
AC Q4UHR0;
DT 05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 121.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=TA06695 {ECO:0000313|EMBL:CAI73379.1};
OS Theileria annulata.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Theileriidae; Theileria.
OX NCBI_TaxID=5874 {ECO:0000313|EMBL:CAI73379.1, ECO:0000313|Proteomes:UP000001950};
RN [1] {ECO:0000313|EMBL:CAI73379.1, ECO:0000313|Proteomes:UP000001950}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ankara {ECO:0000313|Proteomes:UP000001950};
RX PubMed=15994557; DOI=10.1126/science.1110418;
RA Pain A., Renauld H., Berriman M., Murphy L., Yeats C.A., Weir W.,
RA Kerhornou A., Aslett M., Bishop R., Bouchier C., Cochet M., Coulson R.M.R.,
RA Cronin A., de Villiers E.P., Fraser A., Fosker N., Gardner M., Goble A.,
RA Griffiths-Jones S., Harris D.E., Katzer F., Larke N., Lord A., Maser P.,
RA McKellar S., Mooney P., Morton F., Nene V., O'Neil S., Price C.,
RA Quail M.A., Rabbinowitsch E., Rawlings N.D., Rutter S., Saunders D.,
RA Seeger K., Shah T., Squares R., Squares S., Tivey A., Walker A.R.,
RA Woodward J., Dobbelaere D.A.E., Langsley G., Rajandream M.A., McKeever D.,
RA Shiels B., Tait A., Barrell B.G., Hall N.;
RT "Genome of the host-cell transforming parasite Theileria annulata compared
RT with T. parva.";
RL Science 309:131-133(2005).
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|RuleBase:RU004070}.
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DR EMBL; CR940347; CAI73379.1; -; Genomic_DNA.
DR RefSeq; XP_954056.1; XM_948963.1.
DR AlphaFoldDB; Q4UHR0; -.
DR STRING; 5874.Q4UHR0; -.
DR GeneID; 3863484; -.
DR KEGG; tan:TA06695; -.
DR VEuPathDB; PiroplasmaDB:TA06695; -.
DR eggNOG; KOG0481; Eukaryota.
DR InParanoid; Q4UHR0; -.
DR OMA; VIIVNEC; -.
DR OrthoDB; 5476523at2759; -.
DR Proteomes; UP000001950; Chromosome 1 part 1.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR018525; MCM_CS.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR PANTHER; PTHR11630:SF42; DNA REPLICATION LICENSING FACTOR MCM5; 1.
DR Pfam; PF00493; MCM; 2.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00847; MCM_1; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022806};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070};
KW Reference proteome {ECO:0000313|Proteomes:UP000001950}.
FT DOMAIN 372..603
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
SQ SEQUENCE 770 AA; 87407 MW; B075CA930B246014 CRC64;
MLGLQEGRVY NTNVSRGLGD EYLKLPNKLP SLDNVYTYFS SFLNAYSSTS LQQGKLKRTL
LENLKNNNYL LELKLEDLFH FQNVMDTTSE REEESITKQL REANNEDVNS NNRNSEKLPP
FYVHELAKVL TQRPLIYLST IEKVCYDVCK MNMDYEDEKF NFIQINLLNN YASPTPIRSL
LSDKQETFVV VPGIIVQANR TQHKMRVCTI QCRYCGHKMI IEVPLWISRP QIPKTCRYSS
TMKTMGENIH VDQQLGCHSV QNPYVIIVNE CQFVDVQLLK MQELAEDVPT GDMPRHLQLN
VTRYLCDKVI PGDRIYAHGV LTSYNNSPNS HTDINSSYLH VLGIQKLNVN ETYEFDIDEG
NDLLLLASQP DIHTKIFNSI APSIYGLDDV KKACACALFG GTRKEVGNGA KIRGDINILI
LGDPSIAKSQ ILKFIDFIAP ISIYTSGKGS SAAGLTAAVV RDSMGVFSLE GGAMVLADGG
VVCIDEFDKM RPDDAVAIHE AMEQQTISIS KAGITTILNT RCSVIAAANP NLGNFTTQIK
LDISIDLNFN FLILNLILGS YNNYQDNNEQ HDFKTTILSR FDLIFMLKDN EDINHDKLLC
KHILSLHNNQ NKQNVVGPIS NNKLRRFIQY SKQVVSPILS NEAKDSLRNF YVQKRKEYRE
DKRSSTKKIP ITLRQLESLV RVSESLARME LSPIASEKHV QMAIQLFIVS TGEAMKSTLN
VDNMSLDDQH KIKLSEELIL NIVKKGQRTT RRFIIKELQK QYINMVYIQQ
//
