ID   Q4UKN2_RICFE            Unreviewed;       355 AA.
AC   Q4UKN2;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   27-MAR-2024, entry version 86.
DE   SubName: Full=Multidrug resistance protein A {ECO:0000313|EMBL:AAY61895.1};
GN   Name=emrA {ECO:0000313|EMBL:AAY61895.1};
GN   OrderedLocusNames=RF_1044 {ECO:0000313|EMBL:AAY61895.1};
OS   Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=315456 {ECO:0000313|EMBL:AAY61895.1, ECO:0000313|Proteomes:UP000008548};
RN   [1] {ECO:0000313|EMBL:AAY61895.1, ECO:0000313|Proteomes:UP000008548}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-1525 / URRWXCal2 {ECO:0000313|Proteomes:UP000008548};
RX   PubMed=15984913; DOI=10.1371/journal.pbio.0030248;
RA   Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.E.,
RA   Parinello H., Claverie J.M., Raoult D.;
RT   "The genome sequence of Rickettsia felis identifies the first putative
RT   conjugative plasmid in an obligate intracellular parasite.";
RL   PLoS Biol. 3:1-12(2005).
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DR   EMBL; CP000053; AAY61895.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q4UKN2; -.
DR   STRING; 315456.RF_1044; -.
DR   KEGG; rfe:RF_1044; -.
DR   eggNOG; COG1566; Bacteria.
DR   HOGENOM; CLU_018816_15_1_5; -.
DR   Proteomes; UP000008548; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.30.170; -; 1.
DR   Gene3D; 2.40.50.100; -; 1.
DR   Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR   InterPro; IPR032317; HlyD_D23.
DR   InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR   PANTHER; PTHR30386; MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP; 1.
DR   PANTHER; PTHR30386:SF24; MULTIDRUG RESISTANCE EFFLUX PUMP; 1.
DR   Pfam; PF13533; Biotin_lipoyl_2; 1.
DR   Pfam; PF16576; HlyD_D23; 1.
DR   SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE   4: Predicted;
KW   Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022519};
KW   Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          61..106
FT                   /note="Membrane fusion protein biotin-lipoyl like"
FT                   /evidence="ECO:0000259|Pfam:PF13533"
FT   DOMAIN          162..302
FT                   /note="RND efflux pump membrane fusion protein barrel-
FT                   sandwich"
FT                   /evidence="ECO:0000259|Pfam:PF16576"
FT   COILED          165..213
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   355 AA;  39654 MW;  A627E04E717A8071 CRC64;
     MVKLIMPSVL QQAIDKYKHH PFTKYVIIIA LIIFIYLGYK IYVWANTQST DNAYIDADIS
     NVSAEVSGVL TKLFVTDNTK VNKGDLIGEI DDRDYKAKLA ALEASIEACI KNIEIIEQKI
     SIGQISLEQA SEKLKLTKIS FDIVSTDFTR VQELNKAKFA SSKTLDDSKN AYQKAKTDYK
     QAQLDLDISK QNLQLLELEK AAEQEKLKEL TENKKVTLRS LQNTKLIAMV PGIFGNSSLE
     VGNYIVPGRA LFSIVQDNTM YIQANFKETQ IKKFKSGMKV KIEFDALPKK IIYGKIRNIA
     PATGSKFSLI PPDNATGNFT KIVQRVPVLI DFESPNANLV PGMSAIVSIR TDQST
//