ID Q4VDF8_CRYGA Unreviewed; 225 AA.
AC Q4VDF8; Q870L6;
DT 05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE RecName: Full=orotate phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00011971};
DE EC=2.4.2.10 {ECO:0000256|ARBA:ARBA00011971};
GN Name=URA5 {ECO:0000313|EMBL:AAY42415.1};
GN Synonyms=ura5 {ECO:0000313|EMBL:CAD88490.1};
OS Cryptococcus gattii (Filobasidiella gattii) (Cryptococcus bacillisporus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus gattii species complex.
OX NCBI_TaxID=552467 {ECO:0000313|EMBL:AAY42415.1};
RN [1] {ECO:0000313|EMBL:CAD88490.1}
RP NUCLEOTIDE SEQUENCE.
RA Jackson S.;
RT "The URA5 gene of Cryptococcus neoformans: Its use as an auxotrophic
RT selection marker for biolistic transformation and as a target for RFLP
RT targeting.";
RL Thesis (2001), University of Western Sydney, Campbelltown, Australia.
RN [2] {ECO:0000313|EMBL:CAD88490.1}
RP NUCLEOTIDE SEQUENCE.
RA Kidd S.E.;
RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AAY42415.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JH3643 {ECO:0000313|EMBL:AAY42415.1}, and JH3733
RC {ECO:0000313|EMBL:AAY42414.1};
RX PubMed=16087746; DOI=10.1128/EC.4.8.1410-1419.2005;
RA Campbell L.T., Fraser J.A., Nichols C.B., Dietrich F.S., Carter D.,
RA Heitman J.;
RT "Clinical and environmental isolates of Cryptococcus gattii from Australia
RT that retain sexual fecundity.";
RL Eukaryot. Cell 4:1410-1419(2005).
CC -!- FUNCTION: Catalyzes the transfer of a ribosyl phosphate group from 5-
CC phosphoribose 1-diphosphate to orotate, leading to the formation of
CC orotidine monophosphate (OMP). {ECO:0000256|ARBA:ARBA00003769}.
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC UMP from orotate: step 1/2. {ECO:0000256|ARBA:ARBA00004889}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase
CC family. PyrE subfamily. {ECO:0000256|ARBA:ARBA00006340}.
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DR EMBL; AY973637; AAY42414.1; -; Genomic_DNA.
DR EMBL; AY973638; AAY42415.1; -; Genomic_DNA.
DR EMBL; AJ555834; CAD88490.1; -; Genomic_DNA.
DR AlphaFoldDB; Q4VDF8; -.
DR VEuPathDB; FungiDB:CGB_G1340W; -.
DR VEuPathDB; FungiDB:CNBG_2389; -.
DR VEuPathDB; FungiDB:I306_05139; -.
DR VEuPathDB; FungiDB:I308_00702; -.
DR VEuPathDB; FungiDB:I311_03073; -.
DR VEuPathDB; FungiDB:I314_01728; -.
DR UniPathway; UPA00070; UER00119.
DR GO; GO:0004588; F:orotate phosphoribosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd06223; PRTases_typeI; 1.
DR Gene3D; 3.40.50.2020; -; 1.
DR HAMAP; MF_01208; PyrE; 1.
DR InterPro; IPR023031; OPRT.
DR InterPro; IPR004467; Or_phspho_trans_dom.
DR InterPro; IPR000836; PRibTrfase_dom.
DR InterPro; IPR029057; PRTase-like.
DR NCBIfam; TIGR00336; pyrE; 1.
DR PANTHER; PTHR46683; OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED; 1.
DR PANTHER; PTHR46683:SF1; OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED; 1.
DR Pfam; PF00156; Pribosyltran; 1.
DR SUPFAM; SSF53271; PRTase-like; 1.
PE 3: Inferred from homology;
KW Pyrimidine biosynthesis {ECO:0000256|ARBA:ARBA00022975}.
FT DOMAIN 70..182
FT /note="Phosphoribosyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00156"
SQ SEQUENCE 225 AA; 24491 MW; 35FDF6A5FCCE613C CRC64;
MSSQALDSAK VAFIEAAIEH GVLLFGNFTL KSGRQSPYFF NAGLLYSSSL LSTTAQAYAK
ILSSSRIPDF DVLFGPAYKG ISLAAVSAVS LYQQTGKDIG YCYNRKEKKD HGEGGTMVGA
PLKGRIVIID DVLTSGKAIR EAIDILKASP EAKLVGIVQL VDRQEKGQSG SGKSTVQEVE
EEFGVPVEPI IGLDDIVKYL ESSGKWEKEL QEVRKYREEY GVQRS
//
