ID   Q4VE16_BOVIN            Unreviewed;       747 AA.
AC   Q4VE16;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   22-FEB-2023, entry version 79.
DE   SubName: Full=DNA polymerase iota {ECO:0000313|EMBL:AAY46031.1};
GN   Name=POLI {ECO:0000313|EMBL:AAY46031.1};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|EMBL:AAY46031.1};
RN   [1] {ECO:0000313|EMBL:AAY46031.1}
RP   NUCLEOTIDE SEQUENCE.
RA   McDonald J.P., Woodgate R.;
RT   "Complete sequence of bovine DNA polymerase iota.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AY965877; AAY46031.1; -; mRNA.
DR   RefSeq; NP_001019863.1; NM_001024692.1.
DR   AlphaFoldDB; Q4VE16; -.
DR   GeneID; 515909; -.
DR   KEGG; bta:515909; -.
DR   CTD; 11201; -.
DR   OrthoDB; 2918002at2759; -.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   CDD; cd01703; PolY_Pol_iota; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.40.1170.60; -; 1.
DR   Gene3D; 6.10.250.1630; -; 2.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   Gene3D; 3.30.1490.100; DNA polymerase, Y-family, little finger domain; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR   InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR001126; UmuC.
DR   PANTHER; PTHR46404; DNA POLYMERASE IOTA; 1.
DR   PANTHER; PTHR46404:SF1; DNA POLYMERASE IOTA; 1.
DR   Pfam; PF00817; IMS; 1.
DR   Pfam; PF11799; IMS_C; 1.
DR   PIRSF; PIRSF036603; DPol_eta; 2.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF100879; Lesion bypass DNA polymerase (Y-family), little finger domain; 1.
DR   PROSITE; PS50173; UMUC; 1.
PE   2: Evidence at transcript level;
KW   DNA synthesis {ECO:0000256|ARBA:ARBA00022634}.
FT   DOMAIN          65..278
FT                   /note="UmuC"
FT                   /evidence="ECO:0000259|PROSITE:PS50173"
FT   REGION          1..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          322..342
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          491..528
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          585..655
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          674..715
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..26
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        500..516
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        597..631
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        632..647
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        674..688
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        689..715
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   747 AA;  83752 MW;  278A5F02B7EC6B8D CRC64;
     MEKRGVEPEE AGGGDEEADE TRAMERAEAG APGGWPGALE PDELDDLPWL HDELEPAGSS
     SCRVIVHVDL DCFYAQVEMI SNPELKDKPL GVQQKYLVVT CNYEARKLGV KKLMSVRDAK
     EKCPQLVLVN GEDLTRYREM SYKVTELLEE FSPVVERLGF DENFVDLTEM VEKRLEQLQS
     DELSALTVSG HVYNNQPVNP RDTLHIRLLV GSQIVAEMRE AMYQQLGLTG CAGVASNKLL
     AKLVSGVFKP NQQTVLLPES SQELIHSLNH IKEMPGIGYK TTKRLEALGI SSVRDLQTFP
     SKVLEKELGI SVAQRIQKLS FGEDDSPVTP SGPPQSFSEE DSFKKCSSEV EAKTKIEELL
     ASLLNRVCQD GRKPHTIRLI IRRYSSEKHY NRESRQCPIP SHIIQKLGAG NYDVMTPMVD
     ILMKLFRNMV NVKVPFHLTL LSVCFCNLKS LNTAKKGTMD YYLTPSLSTT SHAGKRSFKM
     KDCHMEDFSK DKETNRDFLP TGRIESTRTG ESPPDPINSS KEKDSNEFPV SLLPEDIDQE
     VFKQLPVDIQ EEILSGKSRE KVQGKGSLSC PLRASRGVLS FFSTKQKQDS SLNPKDHVPK
     SKQVSSVSPC EPGTSGGSSS SYVSSQKEYS HYLDSSLKDE RMSQGPKESQ RFHFSNTNPA
     VSVFHSFPNL QSEQLLSKNR TTDSHKQPVA TVSRHEGLKE NREQESPDEK IAFPSDIDPE
     VFYELPEEVQ KELLADWKRT GSDFHTT
//