ID   Q4VSR1_CARAU            Unreviewed;       139 AA.
AC   Q4VSR1;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   RecName: Full=ornithine decarboxylase {ECO:0000256|ARBA:ARBA00034138};
DE            EC=4.1.1.17 {ECO:0000256|ARBA:ARBA00034138};
DE   Flags: Fragment;
OS   Carassius auratus (Goldfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Carassius.
OX   NCBI_TaxID=7957 {ECO:0000313|EMBL:AAV34288.1};
RN   [1] {ECO:0000313|EMBL:AAV34288.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:AAV34288.1};
RX   PubMed=15869561; DOI=10.1111/j.1365-2826.2005.01311.x;
RA   Martyniuk C.J., Crawford A.B., Hogan N.S., Trudeau V.L.;
RT   "GABAergic modulation of the expression of genes involved in GABA synaptic
RT   transmission and stress in the hypothalamus and telencephalon of the female
RT   goldfish (Carassius auratus).";
RL   J. Neuroendocrinol. 17:269-275(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + L-ornithine = CO2 + putrescine; Xref=Rhea:RHEA:22964,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:46911,
CC         ChEBI:CHEBI:326268; EC=4.1.1.17;
CC         Evidence={ECO:0000256|ARBA:ARBA00034037};
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
CC   -!- PATHWAY: Amine and polyamine biosynthesis; putrescine biosynthesis via
CC       L-ornithine pathway; putrescine from L-ornithine: step 1/1.
CC       {ECO:0000256|ARBA:ARBA00034115}.
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DR   EMBL; AY640230; AAV34288.1; -; mRNA.
DR   AlphaFoldDB; Q4VSR1; -.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0006596; P:polyamine biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.20.20.10; Alanine racemase; 1.
DR   InterPro; IPR009006; Ala_racemase/Decarboxylase_C.
DR   InterPro; IPR022657; De-COase2_CS.
DR   InterPro; IPR022644; De-COase2_N.
DR   InterPro; IPR002433; Orn_de-COase.
DR   InterPro; IPR029066; PLP-binding_barrel.
DR   PANTHER; PTHR11482; ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE; 1.
DR   PANTHER; PTHR11482:SF42; ORNITHINE DECARBOXYLASE; 1.
DR   Pfam; PF02784; Orn_Arg_deC_N; 1.
DR   SUPFAM; SSF51419; PLP-binding barrel; 1.
DR   PROSITE; PS00879; ODR_DC_2_2; 1.
PE   2: Evidence at transcript level;
FT   DOMAIN          1..91
FT                   /note="Orn/DAP/Arg decarboxylase 2 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02784"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAV34288.1"
FT   NON_TER         139
FT                   /evidence="ECO:0000313|EMBL:AAV34288.1"
SQ   SEQUENCE   139 AA;  15029 MW;  2A0A317D8D4538A3 CRC64;
     VIGVSFHVGS GCPDPETYSQ AISDARYVFD MGAELGYNMT LLDIGGGFPG SDDAKLKFEE
     IAAVIKPALD KYLPVDCGVR IIAEPGRYYV ASAYTLAVNI IAKKVIMKEQ SSSDEEEDGA
     SDRTLMYYVN DGVYGSFNC
//