ID Q4VSR6_PIG Unreviewed; 289 AA.
AC Q4VSR6; A0A4X1V8G6; I3L617;
DT 05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2005, sequence version 1.
DT 24-JAN-2024, entry version 110.
DE RecName: Full=Tumor necrosis factor ligand superfamily member {ECO:0000256|PIRNR:PIRNR038013};
GN Name=TRAIL {ECO:0000313|EMBL:AAV54594.1};
GN Synonyms=GHSR {ECO:0000313|Ensembl:ENSSSCP00000043731.1}, TNFSF10
GN {ECO:0000313|Ensembl:ENSSSCP00005008416.1};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|EMBL:AAV54594.1};
RN [1] {ECO:0000313|EMBL:AAV54594.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16093724; DOI=10.1159/000085673;
RA Kemter E., Philipp U., Klose R., Kuiper H., Boelhauve M., Distl O.,
RA Wolf E., Leeb T.;
RT "Molecular cloning, expression analysis and assignment of the porcine tumor
RT necrosis factor superfamily member 10 gene (TNFSF10) to SSC13q34-->q36 by
RT fluorescence in situ hybridization and radiation hybrid mapping.";
RL Cytogenet. Genome Res. 111:74-78(2005).
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000043731.1, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000043731.1,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:HDA54448.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [4] {ECO:0000313|Ensembl:ENSSSCP00005008416.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBUNIT: Homotrimer. {ECO:0000256|PIRNR:PIRNR038013}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670, ECO:0000256|PIRNR:PIRNR038013}.
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DR EMBL; AY639873; AAV54594.1; -; mRNA.
DR EMBL; DQIR01098972; HDA54448.1; -; Transcribed_RNA.
DR EMBL; DQIR01204002; HDB59479.1; -; Transcribed_RNA.
DR RefSeq; NP_001019867.1; NM_001024696.1.
DR PaxDb; 9823-ENSSSCP00000030592; -.
DR Ensembl; ENSSSCT00000042290.3; ENSSSCP00000043731.1; ENSSSCG00000020906.5.
DR Ensembl; ENSSSCT00005014126.1; ENSSSCP00005008416.1; ENSSSCG00005009157.1.
DR GeneID; 406191; -.
DR KEGG; ssc:406191; -.
DR CTD; 8743; -.
DR eggNOG; ENOG502QQ3R; Eukaryota.
DR GeneTree; ENSGT01100000263484; -.
DR OMA; EPIMLMK; -.
DR OrthoDB; 5348190at2759; -.
DR Proteomes; UP000008227; Chromosome 13.
DR Bgee; ENSSSCG00000020906; Expressed in caecum and 42 other cell types or tissues.
DR Genevisible; Q4VSR6; SS.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006955; P:immune response; IEA:UniProtKB-UniRule.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR021184; TNF_CS.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR017355; TNF_ligand_10/11.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR11471; TUMOR NECROSIS FACTOR FAMILY MEMBER; 1.
DR PANTHER; PTHR11471:SF27; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 10; 1.
DR Pfam; PF00229; TNF; 1.
DR PIRSF; PIRSF038013; TNF10_TNF11; 1.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS00251; TNF_1; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 2: Evidence at transcript level;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|PIRNR:PIRNR038013};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR038013};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR038013-50};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|PIRSR:PIRSR038013-50}.
FT TRANSMEM 17..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 123..288
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
FT BINDING 238
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="ligand shared between all trimeric partners"
FT /evidence="ECO:0000256|PIRSR:PIRSR038013-50"
SQ SEQUENCE 289 AA; 33564 MW; 0277B9EDFF5B114F CRC64;
MAVMQTPGGP SPGQTCVLIL IFTVLLQALC VALTYVYFTN ELKQMQDKYS KSGIACFLKE
DDSFWDPTDD ERMLSPCWQV KWQLRQFVRK MILRTYEETI STVSEKQQGI PHLEREKGPQ
RVAAHITGTS RKRSTFPSLS SKYEKALGQK INSWESSRKG HSFLNNFHLR NGELVIHQTG
FYYIYSQTYF RFQEPEEILG TVSTEGNRKK NRQMIQYIYK WTSYPDPILL MKSARNSCWS
KDSEYGLYSI YQGGIFELKE DDRIFVSVTN EQLIDMDQEA SFFGAFLIG
//