ID   Q4W4T2_TRYRA            Unreviewed;       651 AA.
AC   Q4W4T2;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   27-MAR-2024, entry version 67.
DE   SubName: Full=Surface glycoprotein {ECO:0000313|EMBL:AAY46228.1};
OS   Trypanosoma rangeli.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Herpetosoma.
OX   NCBI_TaxID=5698 {ECO:0000313|EMBL:AAY46228.1};
RN   [1] {ECO:0000313|EMBL:AAY46228.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=DOG-82 {ECO:0000313|EMBL:AAY46228.1};
RX   PubMed=11897137; DOI=10.1016/S0166-6851(02)00005-1;
RA   Chiurillo M.A., Peralta A., Ramirez J.L.;
RT   "Comparative study of Trypanosoma rangeli and Trypanosoma cruzi
RT   telomeres.";
RL   Mol. Biochem. Parasitol. 120:305-308(2002).
RN   [2] {ECO:0000313|EMBL:AAY46228.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=DOG-82 {ECO:0000313|EMBL:AAY46228.1};
RX   PubMed=15907566; DOI=10.1016/j.molbiopara.2005.03.012;
RA   Anez-Rojas N., Peralta A., Crisante G., Rojas A., Anez N., Ramirez J.L.,
RA   Chiurillo M.A.;
RT   "Trypanosoma rangeli expresses a gene of the group II trans-sialidase
RT   superfamily.";
RL   Mol. Biochem. Parasitol. 142:133-136(2005).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF426022; AAY46228.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q4W4T2; -.
DR   CAZy; GH33; Glycoside Hydrolase Family 33.
DR   VEuPathDB; TriTrypDB:TRSC58_06964; -.
DR   VEuPathDB; TriTrypDB:TRSC58_07108; -.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   InterPro; IPR008377; Sialidase_trypan.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13859; BNR_3; 1.
DR   PRINTS; PR01803; TCSIALIDASE.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   4: Predicted;
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           27..651
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004245279"
FT   DOMAIN          65..403
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13859"
SQ   SEQUENCE   651 AA;  71722 MW;  FB3E28DBE2F74E50 CRC64;
     MSRHMFFFSV LLLLVLMAFG STAVYAESNT RNKMQLPEAI DLFVARQTIV VTQGLIELRD
     SFVFPSLASA DGVLVALAEG NIHFKHAYQK ERWVTYADVV AGYMDSAESW SSFVAEVRAN
     DWWAHSIFNT SVQEEHNGSL RYVYRPTTIA KGNKVFLLVG GLHHKYDPSS KMWTKSSRDF
     DLLVGEATQG KAIQWGEPTS LWPQIKPSAK QRGLKQLLGG GGSGVVMEDG TFVFPVTAKR
     RGKGLVSMII YSKDDGKTWV LAEGMLPTGF TDPLIVEWER GQLLMVAKCY SGSKVFESRD
     MGATWTEAAR TLTRLRPMLL PNTLRTAEGV GSLTTATIAG KKVMLYTQKG VLPGGSLQAT
     ALYLWVTDNN RTFEVGPISM DTTEEITSSN TLLYSNDALH LLQERVSKTT TGVSLASLTK
     ELKTITSVLE TWAKLDASLS NSSVPTAGLV GFLSDASGDG TWNDAYRCLD ATVTNATKVE
     DGFKFTGSKS YAMWPVNMRE YHNVHSFVDY AFTLVATVII DEVPNGSASL LGAGLEDNEN
     MTFVGLSYTL ANEWETVFKG IAPTRSKITW EAGKEYQVAL MLQGNEGSVY VDGVVVGSFH
     TLPTSGERWH EITHFYFGGG RDGSARVKNV FLYNRPLSVM QLKEVDSFRC L
//