ID Q4WNQ3_ASPFU Unreviewed; 1167 AA.
AC Q4WNQ3;
DT 05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2005, sequence version 1.
DT 24-JAN-2024, entry version 117.
DE SubName: Full=Ras guanine-nucleotide exchange protein, putative {ECO:0000313|EMBL:EAL90131.1};
GN ORFNames=AFUA_4G06570 {ECO:0000313|EMBL:EAL90131.1};
OS Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 /
OS Af293) (Neosartorya fumigata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL90131.1, ECO:0000313|Proteomes:UP000002530};
RN [1] {ECO:0000313|EMBL:EAL90131.1, ECO:0000313|Proteomes:UP000002530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC {ECO:0000313|Proteomes:UP000002530};
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL90131.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAHF01000005; EAL90131.1; -; Genomic_DNA.
DR RefSeq; XP_752169.1; XM_747076.1.
DR AlphaFoldDB; Q4WNQ3; -.
DR STRING; 330879.Q4WNQ3; -.
DR EnsemblFungi; EAL90131; EAL90131; AFUA_4G06570.
DR GeneID; 3509195; -.
DR KEGG; afm:AFUA_4G06570; -.
DR VEuPathDB; FungiDB:Afu4g06570; -.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_002116_1_0_1; -.
DR InParanoid; Q4WNQ3; -.
DR OMA; CVRGAGD; -.
DR OrthoDB; 68574at2759; -.
DR PHI-base; PHI:8876; -.
DR Proteomes; UP000002530; Chromosome 4.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF354; GUANINE-NUCLEOTIDE EXCHANGE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06570)-RELATED; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000002530};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 71..137
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 701..821
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 881..1124
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 275..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 506..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 578..597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..61
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..333
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 510..524
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..569
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1167 AA; 129029 MW; A1B3BF6A578F3C28 CRC64;
MEPMKRHIAP LKVEKTITNP CGSTTSESGD PSSNHHYSTQ HSLQLSPPLT PYCATSSKDN
SMDRTEAPRA VFHNYLRAFY PFHPPGDVSP DTITLPLDQG DIILVHSVHT NGWADGTLLD
TGARGWLPTN YCEAYDQLPM RPLLKALTDF WDIIRGGCGS SLRDFGNQDL VRGLIAGVRF
LLEKSECLTR DSFLVRRHEG LRRNRKALLS DLTALVRTTK SFQVIASGNP LQDEVEYMVD
EMLLKAFRVV TRGVRFLDIW NEEVGLSRTI AELEQSKDHT SPLTPASETF VMSEKAPSEA
ETERNESRVL NSSRMSMSRC STRVDMSEQP RPVSVATKRI SISHRVSYSG PAAASRNPNL
ASERLNATYD AFLGVLGSFI GLHLQSRSST ELVVTTEQAV RSCRGLLTVV EAVCEHDSQG
SSLLESAKDA MYERLSELVF AARDAFRPAQ SPDDELVFMP DEGKRLVDAA TDCVRAAGNC
LAKARLVLEQ VGDFELEALP QDVATPLVGA GPESQSQQQK GDQPELSMRL PPPPLQIPQN
ADLDSSPPTP GLTDDTTPSS SFNSRNLSNP TIAATDEASL PSANIPPPSP AKSSFSSSCD
AAAGVKVLEN RISHPKSEIG ESFGRGVTST GSSFTYHSHL RDSEMSGVSQ TSTRATSPDI
GSCYQAPSLK SCVSHSTLAE EGEETEVNIL EKTYAHELIF KDGQVMGGSL RALIERLTSH
GSTPDAMFVS TFYLTFRLFA TPLEFAEALV ERFNYIGDTP HAAGPVRLRV YNVFKGWLES
HWRHDCDDSA LDFIVNFAKT TLMQSLPSAG KRLLELTDKV STLQGPVVPR LISSIGKTNT
ATAQYVHPDT PLPPPILSKK EVNLLKQWKN GEAAISILDF DPLELARQLT IKESRIFCAI
LPEELLATEW MKKSASLAVN VRAMSTLSTD LAHLVADSIL QLEEPKKRAA IIKQWVKIAN
KCLELNNYDT LMAIICSLNS SMISRLKRTW EVVSQKTKAT LETLRGIVDV SRNYAVLRQR
LQTHVPPCLP FVGTYLTDLT FVDHGNQPLR SLPTDDGEMT VINFDKHMKT AKIISELQRF
QVPYRLTEVP ELQTWMQNEL VRVRSNGEKS LQTFYRRSLI LEPREITPRP NLQPESSASS
IMENARDKFD LFAWTHPSKA KSVATNS
//