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Database: UniProt
Entry: Q4WNQ3_ASPFU
LinkDB: Q4WNQ3_ASPFU
Original site: Q4WNQ3_ASPFU 
ID   Q4WNQ3_ASPFU            Unreviewed;      1167 AA.
AC   Q4WNQ3;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   24-JAN-2024, entry version 117.
DE   SubName: Full=Ras guanine-nucleotide exchange protein, putative {ECO:0000313|EMBL:EAL90131.1};
GN   ORFNames=AFUA_4G06570 {ECO:0000313|EMBL:EAL90131.1};
OS   Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 /
OS   Af293) (Neosartorya fumigata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL90131.1, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EAL90131.1, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA   Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA   Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA   Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA   Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA   Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA   Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA   Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA   Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA   Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA   Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA   Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA   Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA   Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL90131.1}.
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DR   EMBL; AAHF01000005; EAL90131.1; -; Genomic_DNA.
DR   RefSeq; XP_752169.1; XM_747076.1.
DR   AlphaFoldDB; Q4WNQ3; -.
DR   STRING; 330879.Q4WNQ3; -.
DR   EnsemblFungi; EAL90131; EAL90131; AFUA_4G06570.
DR   GeneID; 3509195; -.
DR   KEGG; afm:AFUA_4G06570; -.
DR   VEuPathDB; FungiDB:Afu4g06570; -.
DR   eggNOG; KOG3417; Eukaryota.
DR   HOGENOM; CLU_002116_1_0_1; -.
DR   InParanoid; Q4WNQ3; -.
DR   OMA; CVRGAGD; -.
DR   OrthoDB; 68574at2759; -.
DR   PHI-base; PHI:8876; -.
DR   Proteomes; UP000002530; Chromosome 4.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR   GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF354; GUANINE-NUCLEOTIDE EXCHANGE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06570)-RELATED; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          71..137
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          701..821
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          881..1124
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          1..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          275..333
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          506..569
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          578..597
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        17..61
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        309..333
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        510..524
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        539..569
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1167 AA;  129029 MW;  A1B3BF6A578F3C28 CRC64;
     MEPMKRHIAP LKVEKTITNP CGSTTSESGD PSSNHHYSTQ HSLQLSPPLT PYCATSSKDN
     SMDRTEAPRA VFHNYLRAFY PFHPPGDVSP DTITLPLDQG DIILVHSVHT NGWADGTLLD
     TGARGWLPTN YCEAYDQLPM RPLLKALTDF WDIIRGGCGS SLRDFGNQDL VRGLIAGVRF
     LLEKSECLTR DSFLVRRHEG LRRNRKALLS DLTALVRTTK SFQVIASGNP LQDEVEYMVD
     EMLLKAFRVV TRGVRFLDIW NEEVGLSRTI AELEQSKDHT SPLTPASETF VMSEKAPSEA
     ETERNESRVL NSSRMSMSRC STRVDMSEQP RPVSVATKRI SISHRVSYSG PAAASRNPNL
     ASERLNATYD AFLGVLGSFI GLHLQSRSST ELVVTTEQAV RSCRGLLTVV EAVCEHDSQG
     SSLLESAKDA MYERLSELVF AARDAFRPAQ SPDDELVFMP DEGKRLVDAA TDCVRAAGNC
     LAKARLVLEQ VGDFELEALP QDVATPLVGA GPESQSQQQK GDQPELSMRL PPPPLQIPQN
     ADLDSSPPTP GLTDDTTPSS SFNSRNLSNP TIAATDEASL PSANIPPPSP AKSSFSSSCD
     AAAGVKVLEN RISHPKSEIG ESFGRGVTST GSSFTYHSHL RDSEMSGVSQ TSTRATSPDI
     GSCYQAPSLK SCVSHSTLAE EGEETEVNIL EKTYAHELIF KDGQVMGGSL RALIERLTSH
     GSTPDAMFVS TFYLTFRLFA TPLEFAEALV ERFNYIGDTP HAAGPVRLRV YNVFKGWLES
     HWRHDCDDSA LDFIVNFAKT TLMQSLPSAG KRLLELTDKV STLQGPVVPR LISSIGKTNT
     ATAQYVHPDT PLPPPILSKK EVNLLKQWKN GEAAISILDF DPLELARQLT IKESRIFCAI
     LPEELLATEW MKKSASLAVN VRAMSTLSTD LAHLVADSIL QLEEPKKRAA IIKQWVKIAN
     KCLELNNYDT LMAIICSLNS SMISRLKRTW EVVSQKTKAT LETLRGIVDV SRNYAVLRQR
     LQTHVPPCLP FVGTYLTDLT FVDHGNQPLR SLPTDDGEMT VINFDKHMKT AKIISELQRF
     QVPYRLTEVP ELQTWMQNEL VRVRSNGEKS LQTFYRRSLI LEPREITPRP NLQPESSASS
     IMENARDKFD LFAWTHPSKA KSVATNS
//
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