ID Q4WZ31_ASPFU Unreviewed; 541 AA.
AC Q4WZ31;
DT 05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 2.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=Isocitrate dehydrogenase family protein {ECO:0000313|EMBL:EAL92072.2};
DE EC=1.-.-.- {ECO:0000313|EMBL:EAL92072.2};
GN ORFNames=AFUA_3G15140 {ECO:0000313|EMBL:EAL92072.2};
OS Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 /
OS Af293) (Neosartorya fumigata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL92072.2, ECO:0000313|Proteomes:UP000002530};
RN [1] {ECO:0000313|EMBL:EAL92072.2, ECO:0000313|Proteomes:UP000002530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC {ECO:0000313|Proteomes:UP000002530};
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- SIMILARITY: Belongs to the isochorismatase family.
CC {ECO:0000256|ARBA:ARBA00006336}.
CC -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL92072.2}.
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DR EMBL; AAHF01000002; EAL92072.2; -; Genomic_DNA.
DR RefSeq; XP_754110.2; XM_749017.2.
DR AlphaFoldDB; Q4WZ31; -.
DR STRING; 330879.Q4WZ31; -.
DR EnsemblFungi; EAL92072; EAL92072; AFUA_3G15140.
DR GeneID; 3512270; -.
DR KEGG; afm:AFUA_3G15140; -.
DR VEuPathDB; FungiDB:Afu3g15140; -.
DR eggNOG; KOG0785; Eukaryota.
DR HOGENOM; CLU_034665_0_0_1; -.
DR InParanoid; Q4WZ31; -.
DR OMA; FQRGLWT; -.
DR OrthoDB; 47357at2759; -.
DR Proteomes; UP000002530; Chromosome 3.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd00431; cysteine_hydrolases; 1.
DR Gene3D; 3.40.50.850; Isochorismatase-like; 1.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR InterPro; IPR000868; Isochorismatase-like.
DR InterPro; IPR036380; Isochorismatase-like_sf.
DR InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR PANTHER; PTHR43540:SF1; ISOCHORISMATASE HYDROLASE; 1.
DR PANTHER; PTHR43540; PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED; 1.
DR Pfam; PF00180; Iso_dh; 1.
DR Pfam; PF00857; Isochorismatase; 1.
DR SMART; SM01329; Iso_dh; 1.
DR SUPFAM; SSF52499; Isochorismatase-like hydrolases; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Oxidoreductase {ECO:0000313|EMBL:EAL92072.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000002530}.
FT DOMAIN 5..342
FT /note="Isopropylmalate dehydrogenase-like"
FT /evidence="ECO:0000259|SMART:SM01329"
FT REGION 384..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 541 AA; 58567 MW; 71FE39B04443FF48 CRC64;
MPSIQVGLAV GNGTGPELTV IFERVIQSLA ARYNVSVTFL RSPRIYNSYS SLLAINDTDA
VTEETLADAA HYRQFCREAV SCGVRAIFRT SISAQALYLV REQLQAIKIE HFTLSPTSSI
LLVRDQAQGF YSGTNSVNTS KDAVSRTAHF SKAVFTRILS FALVRANQLW GGTNSVTMVY
KFHLFDGLFH TWATEWERTF GVRIRFVQGD TMNRDLLAFG VSGHNLLISG NEYADIMQTI
LLDRFGLGAQ ESACAENVYL HPDVWGLSEY QTAHGSADDL VGKGIVNPTA TIRAAAAVLE
DQAGCAGATQ RVDYVLGDLG AKGIRTPDQG GTATTEAFVE AFLQGLGQPL DAHNGASSWF
SGEANGCGGR GFPERFCHPV QAPIGHGTGG SEHPASGDDH FQGPSWRHRN QMQGRQPWCV
QGTWGAEVFG SVSVQAGERV CDKKAKFDPF LSEEFAQYIA VRGFEELVVA GLYTDVCVDA
TVRGAFQRGL WTTLVSGCTA ALHFSEEQML AYMQRVYGSD VVTMDDLLAT GKENGAVSSS
G
//
