ID Q4WZQ4_ASPFU Unreviewed; 1344 AA.
AC Q4WZQ4;
DT 05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 110.
DE SubName: Full=DEAD/DEAH box helicase, putative {ECO:0000313|EMBL:EAL93911.1};
DE EC=3.6.-.- {ECO:0000313|EMBL:EAL93911.1};
GN ORFNames=AFUA_2G16140 {ECO:0000313|EMBL:EAL93911.1};
OS Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 /
OS Af293) (Neosartorya fumigata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL93911.1, ECO:0000313|Proteomes:UP000002530};
RN [1] {ECO:0000313|EMBL:EAL93911.1, ECO:0000313|Proteomes:UP000002530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC {ECO:0000313|Proteomes:UP000002530};
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL93911.1}.
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DR EMBL; AAHF01000001; EAL93911.1; -; Genomic_DNA.
DR RefSeq; XP_755949.1; XM_750856.1.
DR SMR; Q4WZQ4; -.
DR STRING; 330879.Q4WZQ4; -.
DR EnsemblFungi; EAL93911; EAL93911; AFUA_2G16140.
DR GeneID; 3512919; -.
DR KEGG; afm:AFUA_2G16140; -.
DR VEuPathDB; FungiDB:Afu2g16140; -.
DR eggNOG; KOG0920; Eukaryota.
DR HOGENOM; CLU_001832_4_0_1; -.
DR InParanoid; Q4WZQ4; -.
DR OMA; LFRVCNM; -.
DR OrthoDB; 53793at2759; -.
DR Proteomes; UP000002530; Chromosome 2.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IBA:GO_Central.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR CDD; cd17917; DEXHc_RHA-like; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR006575; RWD_dom.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF145; ATP-DEPENDENT RNA HELICASE DHX29; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR Pfam; PF05773; RWD; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00165; UBA; 2.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54495; UBC-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50908; RWD; 1.
DR PROSITE; PS50030; UBA; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:EAL93911.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:EAL93911.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002530}.
FT DOMAIN 330..371
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT DOMAIN 393..492
FT /note="RWD"
FT /evidence="ECO:0000259|PROSITE:PS50908"
FT DOMAIN 576..752
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 813..983
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 187..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1344 AA; 149127 MW; D2FD56C53733513D CRC64;
MGPKKKPDAR GVPKPGTKQA KAAAERLAEN AKKAQAATEE PKKPSVKEVI GGASWTGKLP
VNMLAEHCQK QKWEKPEYTM MRTSDGYISS VILKRIDPKT RELTVLPPMK PPSSHKHLAA
QPTALEARHF AAAYALFRVC NMRNLHMMLP PTYKKLWKED FTDLKNADTK EGKGWMYEAD
PFLAKQERET AAAEQEKKRK EREKAQAKEK ETAVDLGVGS SGENRGKRIW SQAPKVDLGN
RIRRELEELL RQHTIWNPYN IQISEAERKA IVEEFLGLGF RRSHVEEATA ACRDREEVLE
WLLVYVPEDD LPRWCLPERY TAGVTLASDD LGREAKIKRL ASFGYSADLC AQTLDNKRGD
ELAAAEFLQR TLVHGENHSL DSLSVGDEDS WVEEQDTLEA IFGERYKRLS SKVCEIKSEA
PNIPGSLSFR FQKPSAGYPS SVPVIAIQGT GIPAYIRLSA IRQAVQFAEE NFLGESMIFN
IMDWLETHLP GIIENPGKLR DISTVTGSSS SAVGSFPRLP VRQSRKQSRK IDWNPGSPLG
VSIREAWKAR QSTTAQQEMT RKRESLPAWK IQDAIIQAVN THQVTIISGE TGSGKSTQSV
QFILDDMIKR GLGGVANIIC TQPRRISALG LADRVSDERC TSVGKEVGYI IRGDSRMRPG
ETKITFVTTG VLLRRLQSGS GPDGNVAGSL ADVTHVVVDE VHERSLDTDF LLALLRDVLP
YRPDIKVILM SATLDAEIFM DYFGGREKVG LVNIPGRTFP VSDYYLDDIV RYTGFAPELA
ERGLDEDVMS PPQGDESLGK LLRGLGMGIN YELIASTVRY IDSQLGDQPG GILIFLPGTM
EIERCLNAVR KIPNVHPLPL HASLLPAEQK RVFLSPPKGK RKVIAATNVA ETSITIEDVV
AVIDTGRVKE TSYDPKDNMV RLQEVWASQA ACKQRRGRAG RVRAGSCYKL YTRKAESSMP
QRPEPEIRRV PLEQLCLSVK AMKGIDDVAT FLASTITPPE SVAVEGAIDF LHRVGALDHD
RLTALGRYLS MIPADLRCAK LMVYGSIFGC IDACVTISAI LTVKSPFISP RDKRDEADAA
KASFSKCDGD LLTDLAAYQQ WSERTKAQGY WQTQSWCSAN FLSHQTLRDI SSNRAQFISS
LKDAGILPVD YSDSEPSSAW NRNNGNRSLL RAIIAGAFQP QVAQISFPDK KFASSVTGTV
EIDPDARTIK YFNQENGRVF IHPSSLLFSA QSYSGAAAYL SYFTKMATSK VFIRDLTPFN
PYSLLLFCGS ITLDTMGRGL IVDGWLRLRG WARIGVLVSR LRLMLDEIIA ARIDNPGFSP
ASNDVGDRVI EIVKKLVEFN GLDQ
//
