ID Q4Y2K8_PLACH Unreviewed; 359 AA.
AC Q4Y2K8;
DT 05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2005, sequence version 1.
DT 13-SEP-2023, entry version 74.
DE SubName: Full=4-hydroxy-3-methylbut-2-enyl diphosphate reductase {ECO:0000313|EMBL:ABO21670.1};
GN Name=LytB {ECO:0000313|EMBL:ABO21670.1};
OS Plasmodium chabaudi.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Vinckeia).
OX NCBI_TaxID=5825 {ECO:0000313|EMBL:ABO21670.1};
RN [1] {ECO:0000313|EMBL:ABO21670.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AS-15CQ {ECO:0000313|EMBL:ABO21667.1}, AS-30CQ
RC {ECO:0000313|EMBL:ABO21668.1}, AS-ART {ECO:0000313|EMBL:ABO21669.1},
RC and AS-ASN {ECO:0000313|EMBL:ABO21670.1};
RX PubMed=17581118; DOI=10.1111/j.1365-2958.2007.05753.x;
RA Hunt P., Afonso A., Creasey A., Culleton R., Sidhu A.B., Logan J.,
RA Valderramos S.G., McNae I., Cheesman S., Do Rosario V., Carter R.,
RA Fidock D.A., Cravo P.;
RT "Gene encoding a deubiquitinating enzyme is mutated in artesunate- and
RT chloroquine-resistant rodent malaria parasites.";
RL Mol. Microbiol. 65:27-40(2007).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; EF100417; ABO21667.1; -; Genomic_DNA.
DR EMBL; EF100426; ABO21668.1; -; Genomic_DNA.
DR EMBL; EF100427; ABO21669.1; -; Genomic_DNA.
DR EMBL; EF100428; ABO21670.1; -; Genomic_DNA.
DR AlphaFoldDB; Q4Y2K8; -.
DR VEuPathDB; PlasmoDB:PCHAS_0207100; -.
DR eggNOG; ENOG502QPIQ; Eukaryota.
DR HOGENOM; CLU_038222_0_0_1; -.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0051745; F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0050992; P:dimethylallyl diphosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0019288; P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway; IEA:InterPro.
DR CDD; cd13944; lytB_ispH; 1.
DR Gene3D; 3.40.50.11270; -; 1.
DR Gene3D; 3.40.1010.20; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, catalytic domain; 2.
DR HAMAP; MF_00191; IspH; 1.
DR InterPro; IPR003451; LytB/IspH.
DR NCBIfam; TIGR00216; ispH_lytB; 1.
DR PANTHER; PTHR30426; 4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATE REDUCTASE; 1.
DR PANTHER; PTHR30426:SF0; 4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATE REDUCTASE; 1.
DR Pfam; PF02401; LYTB; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
SQ SEQUENCE 359 AA; 40178 MW; 0115CC171A0B734E CRC64;
MHTNRNEKLN ETKCGGGCGT CSSQVNTNSS ETNDDEKNND KILYLINPRG FCKGVSRAIE
TVEECLKTFK TNIYVKHKIV HNDIVCKDLE SKGAIFIEDL NEVPDGSILI YSAHGISPQI
RELAKKKKLI EIDATCPLVN KVHVYVKLKA KEGYKIILIG YKNHVEVVGT YNEAPDSTYI
VENVEQVNNL NFPENQKLFL VTQTTLSIDD CSLIVNKLKE KYPHIETIPS GSICYATTNR
QKALTKICTE CDLTIVVGSQ SSSNAKKLVY SSQIRNTDAI LVNTVNDFDF SSLKNVKKIA
LTSAASTPDE LTQQFVTVLT SPPYNYKLSI FDGVEETVPK WKLPKELINM IKQKNEKES
//
