ID Q4ZUS9_PSEU2 Unreviewed; 887 AA.
AC Q4ZUS9;
DT 07-JUN-2005, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2005, sequence version 1.
DT 27-MAR-2024, entry version 118.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN OrderedLocusNames=Psyr_2050 {ECO:0000313|EMBL:AAY37093.1};
OS Pseudomonas syringae pv. syringae (strain B728a).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas; Pseudomonas syringae.
OX NCBI_TaxID=205918 {ECO:0000313|EMBL:AAY37093.1, ECO:0000313|Proteomes:UP000000426};
RN [1] {ECO:0000313|EMBL:AAY37093.1, ECO:0000313|Proteomes:UP000000426}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B728a {ECO:0000313|EMBL:AAY37093.1,
RC ECO:0000313|Proteomes:UP000000426};
RX PubMed=16043691; DOI=10.1073/pnas.0504930102;
RA Feil H., Feil W.S., Chain P., Larimer F., Dibartolo G., Copeland A.,
RA Lykidis A., Trong S., Nolan M., Goltsman E., Thiel J., Malfatti S.,
RA Loper J.E., Lapidus A., Detter J.C., Land M., Richardson P.M.,
RA Kyrpides N.C., Ivanova N., Lindow S.E.;
RT "Comparison of the complete genome sequences of Pseudomonas syringae pv.
RT syringae B728a and pv. tomato DC3000.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:11064-11069(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CP000075; AAY37093.1; -; Genomic_DNA.
DR RefSeq; WP_011267402.1; NC_007005.1.
DR RefSeq; YP_235131.1; NC_007005.1.
DR AlphaFoldDB; Q4ZUS9; -.
DR STRING; 205918.Psyr_2050; -.
DR KEGG; psb:Psyr_2050; -.
DR PATRIC; fig|205918.7.peg.2093; -.
DR eggNOG; COG2205; Bacteria.
DR HOGENOM; CLU_000445_113_1_6; -.
DR OrthoDB; 9806130at2; -.
DR Proteomes; UP000000426; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd01987; USP_OKCHK; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.20.120.620; Backbone structure of the membrane domain of e. Coli histidine kinase receptor kdpd; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR038318; KdpD_sf.
DR InterPro; IPR025201; KdpD_TM.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR003852; Sig_transdc_His_kinase_KdpD_N.
DR InterPro; IPR006016; UspA.
DR PANTHER; PTHR45569; SENSOR PROTEIN KDPD; 1.
DR PANTHER; PTHR45569:SF1; SENSOR PROTEIN KDPD; 1.
DR Pfam; PF13493; DUF4118; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF02702; KdpD; 1.
DR Pfam; PF00582; Usp; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:AAY37093.1};
KW Ion channel {ECO:0000313|EMBL:AAY37093.1};
KW Ion transport {ECO:0000313|EMBL:AAY37093.1};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AAY37093.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000313|EMBL:AAY37093.1};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 413..431
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 438..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..486
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 660..877
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 887 AA; 96508 MW; 46555AB16D9604C3 CRC64;
MSDSGRADAL LAQLPREGRG RLKVFLGAAP GVGKTYAMLQ AAHAQLRQGV KVLAGVVETH
GRAETEALLN GLPQQPLLRT DYRGMTLEEM DLDALLKAAP SLVLVDELAH TNAPGSRHTK
RWQDIQELLA AGIDVYTTVN VQHLESLNDH VRGITGVQVR ETLPDWVLQE AFELVLIDLP
PRELLERLRD GKVYVPEQAR AAIDAFFTQT NLTALREMAM QTAAAQVDND LAQGYRQLGQ
SAPAVRGRML VGIDGDIHAE RLVRHASRVA QRRHLPWSAV HVDDGQTLDE QSRARLQSAQ
QLAERLGGEA VSLRAGEVAR TLVQHAIERR ASVVLVGQSR RHWRRRVFGG GVAARLLREG
HGLEISVLDD SEALPDQPPR ARPAREVVWF DYGLAFAATL IASLVAWGVA GVLALPNISL
IFLAAVLLVA VRSSMGPALA CAGLSFLAYD FLFIPPSFSL NIQREEDVLT LLFFLLMSAL
TGKLAARQRR QLQALRDTQE QTSELLDLSR KMTAATDGKA VFSAAEQHFS GWKELHLCLV
DRDGEGGWVV ETGGPLTFSE AERAAADWAW KHDQPAGSGT GTLPSGRWWW WPITAEEGPL
ALLGVCAREG QSFTAQHRRL LAALTQPLAQ ALARAQLAQE LEAARLHGET EQLRSALLAS
VSHDLRTPLT SMRGSIDSLL ALGEAIPLED RRELLEGTRD EAERLDRYIQ NLLDMTRLGH
GALKLARDWV APADIVGSAL NRLRAVLAPL QVSTQVTGEL PLLYVHAALI EQALVNVLEN
AARFSPVDGR LQVAAGVVDS ELFFSVSDEG PGIPEDERAK IFDMFYTAAR GDRGGQGTGL
GLAICQGMIG AHGGRLSVEE GIDGLGTRIT LFLPLQAQPD VELEESA
//
