ID Q503Z1_DANRE Unreviewed; 301 AA.
AC Q503Z1; A0A2R8QFN1; A0A2R8RK30;
DT 07-JUN-2005, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2005, sequence version 1.
DT 27-MAR-2024, entry version 145.
DE SubName: Full=High-mobility group 20B {ECO:0000313|EMBL:AAI34980.1, ECO:0000313|Ensembl:ENSDARP00000061616};
DE SubName: Full=Hmg20b protein {ECO:0000313|EMBL:AAI64068.1};
DE SubName: Full=Novel HMG (High mobility group) box domain containing protein {ECO:0000313|EMBL:CAK10914.1};
DE SubName: Full=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related isoform 1 {ECO:0000313|RefSeq:NP_001018387.1};
GN Name=hmg20b {ECO:0000313|EMBL:AAI34980.1,
GN ECO:0000313|Ensembl:ENSDARP00000061616,
GN ECO:0000313|ZFIN:ZDB-GENE-030131-4258};
GN Synonyms=fc85b02 {ECO:0000313|RefSeq:NP_001018387.1}, si:dkey-110c1.6
GN {ECO:0000313|RefSeq:NP_001018387.1}, wu:fc85b02
GN {ECO:0000313|RefSeq:NP_001018387.1}, zgc:110001
GN {ECO:0000313|RefSeq:NP_001018387.1};
GN ORFNames=DKEY-268M13.4-001 {ECO:0000313|EMBL:CAK10914.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI34980.1};
RN [1] {ECO:0000313|EMBL:AAI34980.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Singapore local strain {ECO:0000313|EMBL:AAI34980.1};
RC TISSUE=Embryo {ECO:0000313|EMBL:AAI34980.1}, Eye
RC {ECO:0000313|EMBL:AAH95120.1}, and PCR rescue
RC {ECO:0000313|EMBL:AAI64068.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CAK10914.1}
RP NUCLEOTIDE SEQUENCE.
RA Matthews N.;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSDARP00000061616}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000061616};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [4] {ECO:0000313|Ensembl:ENSDARP00000061616, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000061616};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [5] {ECO:0000313|RefSeq:NP_001018387.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001018387.1};
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [6] {ECO:0000313|Ensembl:ENSDARP00000146990}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000146990};
RG Ensembl;
RL Submitted (APR-2018) to UniProtKB.
RN [7] {ECO:0000313|RefSeq:NP_001018387.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001018387.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX005203; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC095120; AAH95120.1; -; mRNA.
DR EMBL; BC134979; AAI34980.1; -; mRNA.
DR EMBL; BC164068; AAI64068.1; -; mRNA.
DR EMBL; BX293565; CAK10914.1; -; Genomic_DNA.
DR RefSeq; NP_001018387.1; NM_001020551.2.
DR STRING; 7955.ENSDARP00000061616; -.
DR PaxDb; 7955-ENSDARP00000061616; -.
DR Ensembl; ENSDART00000061617.6; ENSDARP00000061616.4; ENSDARG00000042045.7.
DR Ensembl; ENSDART00000184745.1; ENSDARP00000150793.1; ENSDARG00000116536.1.
DR Ensembl; ENSDART00000188104.1; ENSDARP00000146990.1; ENSDARG00000042045.7.
DR GeneID; 553572; -.
DR KEGG; dre:553572; -.
DR AGR; ZFIN:ZDB-GENE-030131-4258; -.
DR CTD; 10362; -.
DR ZFIN; ZDB-GENE-030131-4258; hmg20b.
DR eggNOG; KOG0381; Eukaryota.
DR OMA; NIDRYMH; -.
DR OrthoDB; 37141at2759; -.
DR TreeFam; TF106440; -.
DR Reactome; R-DRE-3214815; HDACs deacetylate histones.
DR Reactome; R-DRE-983231; Factors involved in megakaryocyte development and platelet production.
DR Proteomes; UP000000437; Alternate scaffold 22.
DR Proteomes; UP000000437; Chromosome 22.
DR Bgee; ENSDARG00000042045; Expressed in mature ovarian follicle and 27 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR CDD; cd22018; HMG-box_HMG20B; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR PANTHER; PTHR46040; HIGH MOBILITY GROUP PROTEIN 2; 1.
DR PANTHER; PTHR46040:SF2; SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY E MEMBER 1-RELATED; 1.
DR Pfam; PF00505; HMG_box; 1.
DR PRINTS; PR00886; HIGHMOBLTY12.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00267};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00267};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q503Z1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 53..121
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 53..121
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 180..235
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 10..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 301 AA; 34348 MW; 7A2B9A1AE141CEEE CRC64;
MGGVKQEQTD APASKDSQQT DSPQEENQST SQPVKKRGWP KGKKRKKVLP NGPKAPVTGY
VRFLNERREH IRALHPDLPF PEITKRLGAE WSRLAPHDKQ RYLDEAERDK MQYARELREY
QKSEAYQITC AKVQDKRIKR EELTSVIINA NSSGSSGFKN SDFTARFDVP IFTEEFLDQN
KAREAELRRL RKANVEFEEQ NAVLQKHIAD MFSAKERLEA ELGQDELRTQ ALQRHLQAIK
QTLVSSLATV PLPGTGETPS IGTLDSYLSR LSSALESRPH EHRALVLKLQ ELLAHLDSEK
L
//
