ID Q50887_MYXXA Unreviewed; 316 AA.
AC Q50887;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1996, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE SubName: Full=CarD protein {ECO:0000313|EMBL:CAA91224.1};
DE SubName: Full=Transcriptional regulator {ECO:0000313|EMBL:UYI12946.1};
GN Name=carD {ECO:0000313|EMBL:CAA91224.1};
GN ORFNames=N3T43_28355 {ECO:0000313|EMBL:UYI12946.1};
OS Myxococcus xanthus.
OC Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC Myxococcaceae; Myxococcus.
OX NCBI_TaxID=34 {ECO:0000313|EMBL:CAA91224.1};
RN [1] {ECO:0000313|EMBL:CAA91224.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DK1050 {ECO:0000313|EMBL:CAA91224.1};
RA Murillo F.;
RL Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CAA91224.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DK1050 {ECO:0000313|EMBL:CAA91224.1};
RX PubMed=8692912; DOI=10.1073/pnas.93.14.6881;
RA Nicolas F.J., Cayuela M.L., Martinez-Argudo I.M., Ruiz-Vazquez R.M.,
RA Murillo F.J.;
RT "High mobility group I(Y)-like DNA-binding domains on a bacterial
RT transcription factor.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:6881-6885(1996).
RN [3] {ECO:0000313|EMBL:CAA91224.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DK1050 {ECO:0000313|EMBL:CAA91224.1};
RX PubMed=16879646; DOI=10.1111/j.1365-2958.2006.05289.x;
RA Penalver-Mellado M., Garcia-Heras F., Padmanabhan S., Garcia-Moreno D.,
RA Murillo F.J., Elias-Arnanz M.;
RT "Recruitment of a novel zinc-bound transcriptional factor by a bacterial
RT HMGA-type protein is required for regulating multiple processes in
RT Myxococcus xanthus.";
RL Mol. Microbiol. 61:910-926(2006).
RN [4] {ECO:0007829|PDB:2LT1}
RP STRUCTURE BY NMR OF 1-72.
RX PubMed=25811865; DOI=10.1371/journal.pone.0121322;
RA Bernal-Bernal D., Gallego-Garcia A., Garcia-Martinez G., Garcia-Heras F.,
RA Jimenez M.A., Padmanabhan S., Elias-Arnanz M.;
RT "Structure-function dissection of Myxococcus xanthus CarD N-terminal
RT domain, a defining member of the CarD_CdnL_TRCF family of RNA polymerase
RT interacting proteins.";
RL PLoS ONE 10:e0121322-e0121322(2015).
RN [5] {ECO:0000313|EMBL:UYI12946.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DK1050 {ECO:0000313|EMBL:UYI12946.1};
RA Lopez-Rojo A., Galbis-Martinez M., Bernal-Bernal D., Padmanabhan S.,
RA Elias-Arnanz M.;
RT "Genome sequencing and assembly of Myxococcus xanthus DK1050 and DK101
RT strains.";
RL Submitted (SEP-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- INTERACTION:
CC Q50887; Q50888: carG; NbExp=2; IntAct=EBI-15797811, EBI-15797822;
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DR EMBL; Z56280; CAA91224.1; -; Genomic_DNA.
DR EMBL; CP104804; UYI12946.1; -; Genomic_DNA.
DR PIR; JC6146; JC6146.
DR RefSeq; WP_011555576.1; NZ_JABFNQ010000026.1.
DR PDB; 2LT1; NMR; -; A=1-72.
DR PDBsum; 2LT1; -.
DR DIP; DIP-58567N; -.
DR IntAct; Q50887; 1.
DR GeneID; 41362868; -.
DR OMA; YPNQGVC; -.
DR Proteomes; UP001164216; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 1.20.58.1290; CarD-like, C-terminal domain; 1.
DR InterPro; IPR017956; AT_hook_DNA-bd_motif.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR042215; CarD-like_C.
DR InterPro; IPR048792; CarD_C.
DR PANTHER; PTHR38447:SF1; RNA POLYMERASE-BINDING TRANSCRIPTION FACTOR CARD; 1.
DR PANTHER; PTHR38447; TRANSCRIPTION FACTOR YDEB-RELATED; 1.
DR Pfam; PF21095; CarD_C; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR PRINTS; PR00929; ATHOOK.
DR SMART; SM00384; AT_hook; 4.
DR SMART; SM01058; CarD_TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:2LT1}.
FT DOMAIN 9..119
FT /note="CarD-like/TRCF RNAP-interacting"
FT /evidence="ECO:0000259|SMART:SM01058"
FT REGION 173..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..226
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..267
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..288
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 316 AA; 34029 MW; B4277B36B2A60858 CRC64;
MPEGSASLQL AVGDRVVYPN QGVCRVSAID VKEVAGQKLT FVTMRREEDG AVVMVPEGKV
LAIGVRKVAS AEDVEAIFTF LRSDSDKADL DWKQRARTNL DRMTQGGIMG LAEVVKGLQV
LSELRPLPTK ERELYDNARH LLVTEVAAAL GTAEVNAEDA IDIVLFPPGR ERPKRTAAEF
QREEGDLDLD SDLLGLDSDL DLPSDEEPSE PSEEESSEEG ESEEAASSEE SAPKKRGRPP
KAKTEAPEGA EPPAPKKRGR PPKPKPEATA EGAEPPAPKK RGRPPKPKPP EVEGAAPAAP
KKRGRPPKVK PPEGES
//
