ID Q509U4_9HIV1 Unreviewed; 241 AA.
AC Q509U4;
DT 07-JUN-2005, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2005, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Protease {ECO:0000313|EMBL:AAY32179.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:AAY32179.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AAY32179.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AAY32179.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=1247 {ECO:0000313|EMBL:AAY32179.1};
RX PubMed=15839752; DOI=10.1371/journal.pmed.0020112;
RA Kantor R., Katzenstein D.A., Efron B., Carvalho A.P., Wynhoven B., Cane P.,
RA Clarke J., Sirivichayakul S., Soares M.A., Snoeck J., Pillay C., Rudich H.,
RA Rodrigues R., Holguin A., Ariyoshi K., Bouzas M.B., Cahn P., Sugiura W.,
RA Soriano V., Brigido L.F., Grossman Z., Morris L., Vandamme A.M., Tanuri A.,
RA Phanuphak P., Weber J.N., Pillay D., Harrigan P.R., Camacho R.,
RA Schapiro J.M., Shafer R.W.;
RT "Impact of HIV-1 Subtype and Antiretroviral Therapy on Protease and Reverse
RT Transcriptase Genotype: Results of a Global Collaboration.";
RL PLoS Med. 2:E112-E112(2005).
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DR EMBL; AY901832; AAY32179.1; -; Genomic_RNA.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Protease {ECO:0000313|EMBL:AAY32179.1};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral release from host cell {ECO:0000256|ARBA:ARBA00023113};
KW Virion maturation {ECO:0000256|ARBA:ARBA00023113}.
FT DOMAIN 27..217
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAY32179.1"
FT NON_TER 241
FT /evidence="ECO:0000313|EMBL:AAY32179.1"
SQ SEQUENCE 241 AA; 28124 MW; 66779D59785AC7B1 CRC64;
GPKVKQWPLT EEKIKALTEI CKEMEEEGKI SKIGPENPYN TPVFAIKKKN STRWRKLVDF
RELNKRTQDF WEVQLGIPHP AGLKKKKSVT VLDVGDAYFS VPLDESFRKY TAFTIPSTNN
ETPGVRYQYN VLPQGWKGSP AIFQSSMTKI LEPFRTKNPE MVIYQYMDDL YVGSDLEIGQ
HRAKIEELRA HLLSWGFITP DQKHQKEPPF LWMGYELHPD RWTVQPIELP EKDSWTVNDI
Q
//
