ID   Q50IU9_SUBDO            Unreviewed;       544 AA.
AC   Q50IU9;
DT   07-JUN-2005, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2005, sequence version 1.
DT   27-MAR-2024, entry version 66.
DE   SubName: Full=Tumour necrosis receptor-associated factor {ECO:0000313|EMBL:CAH04636.1};
GN   Name=tnfr {ECO:0000313|EMBL:CAH04636.1};
OS   Suberites domuncula (Sponge).
OC   Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha; Suberitida;
OC   Suberitidae; Suberites.
OX   NCBI_TaxID=55567 {ECO:0000313|EMBL:CAH04636.1};
RN   [1] {ECO:0000313|EMBL:CAH04636.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=15885494; DOI=10.1016/j.ygeno.2005.02.005;
RA   Schroeder H.C., Perovic-Ottstadt S., Grebenjuk V.A., Engel S.,
RA   Mueller I.M., Mueller W.E.G.;
RT   "Biosilica formation in spicules of the sponge Suberites domuncula:
RT   synchronous expression of a gene cluster.";
RL   Genomics 85:666-678(2005).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   EMBL; AJ784228; CAH04636.1; -; mRNA.
DR   AlphaFoldDB; Q50IU9; -.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd00270; MATH_TRAF_C; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR002083; MATH/TRAF_dom.
DR   InterPro; IPR012227; TNF_rcpt-assoc_TRAF_met.
DR   InterPro; IPR008974; TRAF-like.
DR   InterPro; IPR049342; TRAF_MEP1_MATH_dom.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR10131:SF138; MATH DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR10131; TNF RECEPTOR ASSOCIATED FACTOR; 1.
DR   Pfam; PF21355; TRAF-mep_MATH; 1.
DR   PIRSF; PIRSF015614; TRAF; 2.
DR   SMART; SM00061; MATH; 1.
DR   SUPFAM; SSF49599; TRAF domain-like; 2.
DR   PROSITE; PS50144; MATH; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Receptor {ECO:0000313|EMBL:CAH04636.1}.
FT   DOMAIN          392..536
FT                   /note="MATH"
FT                   /evidence="ECO:0000259|PROSITE:PS50144"
FT   REGION          317..349
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        317..347
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   544 AA;  62142 MW;  5E9A07EF086A2702 CRC64;
     MPGYLGAKPL DPSSVKDGMM CVHCKEILKD PLQTDDGIRL CRSCTTEICY PDRAAQKDII
     KILVACKYVD LGCTWQGFLK DWELHSAGCI CKGVSCPHNG CSSMVAVRHL EGHKLVCPFR
     QDECMHCKLQ LQHNQLEILD HKLNNCHIEE CRVCKQKVNR ETTMELASHP LKSESGPLTV
     HLSDPQTTFR HMQTLSARHD TLSKQVAQVK STLGDVLNDI LRGDKSITDL QANHQQFREL
     CERLSLSMTS VETQFQGLQQ ELLPGARQPV VDKNLLDRVR ELEKLVAERD QVIKKQSQEF
     VEMKRVVEKL QASCDRNTRH IRQRKHDGET RGPTVGQDKH NEGNHGDDVA PLSRLVQLER
     RVEDLSRQTT STQVHVQELE LQLQASLAST HNGAFLWRIP NIARRRRDAV EERITSIYSP
     PFYTGRNGYK MCIRAYLNGD GQGYNTHLSL FFVIMKGEFD NLLKWPFEHK VSMILVDQSH
     RKHVVQTFKP TPESSSFQQP RSDMNVASGC PQFSKLSIFN DDSYCKEDVM YIKCIVDTTK
     IFHP
//