ID Q52MA2_XENLA Unreviewed; 174 AA.
AC Q52MA2;
DT 24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 24-MAY-2005, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE RecName: Full=Guided entry of tail-anchored proteins factor 1 {ECO:0000256|ARBA:ARBA00017951};
DE AltName: Full=Tail-anchored protein insertion receptor WRB {ECO:0000256|ARBA:ARBA00032437};
DE AltName: Full=Tryptophan-rich basic protein {ECO:0000256|ARBA:ARBA00033006};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH90152.1};
RN [1] {ECO:0000313|EMBL:AAH90152.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH90152.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the WRB/GET1 family.
CC {ECO:0000256|ARBA:ARBA00010799}.
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DR EMBL; BC090152; AAH90152.1; -; mRNA.
DR RefSeq; NP_001184198.1; NM_001197269.1.
DR AlphaFoldDB; Q52MA2; -.
DR SMR; Q52MA2; -.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0071816; P:tail-anchored membrane protein insertion into ER membrane; IEA:InterPro.
DR Gene3D; 1.10.287.660; Helix hairpin bin; 1.
DR InterPro; IPR028945; Get1.
DR InterPro; IPR029012; Helix_hairpin_bin_sf.
DR PANTHER; PTHR42650:SF1; GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1; 1.
DR PANTHER; PTHR42650; TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB; 1.
DR Pfam; PF04420; CHD5; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 102..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 149..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT COILED 65..92
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 174 AA; 19867 MW; E0ACE1A6951E4865 CRC64;
MSASETDRWA WLLVLSFVFG CNLLRILLPS LSSFISRVLQ KDAEQESQMR AEIQGMKQEL
STVNMMDEFA RYARLERKIN KMTDKLKTHV KARTAQLAKI KWFISVAFYI LQAALMISLI
WKYYSVPVAV VPSKWITPLD RLVAFPTRVA GGIGITCWIL VCNKVVAIVL HPFS
//
