ID Q52R93_HUMAN Unreviewed; 267 AA.
AC Q52R93;
DT 24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 24-MAY-2005, sequence version 1.
DT 03-MAY-2023, entry version 91.
DE RecName: Full=Olfactory receptor {ECO:0000256|RuleBase:RU363047};
DE Flags: Fragment;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAX86698.1};
RN [1] {ECO:0000313|EMBL:AAX86698.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Olfactory epithelium {ECO:0000313|EMBL:AAX86698.1};
RX PubMed=11689483; DOI=10.1093/hmg/10.21.2363;
RA Mefford H.C., Linardopoulou E., Coil D., van den Engh G., Trask B.J.;
RT "Comparative sequencing of a multicopy subtelomeric region containing
RT olfactory receptor genes reveals multiple interactions between non-
RT homologous chromosomes.";
RL Hum. Mol. Genet. 10:2363-2372(2001).
RN [2] {ECO:0000313|EMBL:AAX86698.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Olfactory epithelium {ECO:0000313|EMBL:AAX86698.1};
RX PubMed=11689484; DOI=10.1093/hmg/10.21.2373;
RA Linardopoulou E., Mefford H.C., Nguyen O., Friedman C., van den Engh G.,
RA Farwell D.G., Coltrera M., Trask B.J.;
RT "Transcriptional activity of multiple copies of a subtelomerically located
RT olfactory receptor gene that is polymorphic in number and location.";
RL Hum. Mol. Genet. 10:2373-2383(2001).
RN [3] {ECO:0000313|EMBL:AAX86698.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Olfactory epithelium {ECO:0000313|EMBL:AAX86698.1};
RA Linardopoulou E., Mefford H.C., Nguyen O., Trask B.J.;
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU363047};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU363047}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; AY972818; AAX86698.1; -; mRNA.
DR AlphaFoldDB; Q52R93; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PANTHER; PTHR48002; OLFACTORY RECEPTOR; 1.
DR PANTHER; PTHR48002:SF51; OLFACTORY RECEPTOR 4F17-RELATED; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|RuleBase:RU363047};
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363047};
KW Olfaction {ECO:0000256|RuleBase:RU363047};
KW Receptor {ECO:0000256|RuleBase:RU000688};
KW Sensory transduction {ECO:0000256|RuleBase:RU363047};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363047}.
FT TRANSMEM 40..61
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363047"
FT TRANSMEM 73..92
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363047"
FT TRANSMEM 112..134
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363047"
FT TRANSMEM 146..168
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363047"
FT TRANSMEM 214..238
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363047"
FT DOMAIN 55..267
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT NON_TER 267
FT /evidence="ECO:0000313|EMBL:AAX86698.1"
SQ SEQUENCE 267 AA; 29534 MW; E46456BDE8CE304D CRC64;
MKKVTAEAIS WNESTSETNN SMVTEFIFLG LSDSQGLQTF LFMLFFVFYG GIVFGNLLIV
ITVVSDSHLH SPMYFLLANL SLIDLSLSSV TAPKMITDFF SQRKVISFKG CLVQIFLLHF
FGGSEMVILI AMGFDRYIAI CKPLHYTTIM CGNACVGIMA VAWGIGFLHS VSQLAFAVHL
PFCGPNEVDS FYCDLPRVIK LACTDTYRLD IMVIANSGVL TVCSFVLLII SYTIILMTIQ
HRPLDKSSKA LSTLTAHITV VLLFFGP
//
