ID   Q53IC0_STRGR            Unreviewed;       325 AA.
AC   Q53IC0;
DT   24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT   24-MAY-2005, sequence version 1.
DT   27-MAR-2024, entry version 61.
DE   SubName: Full=Putative 3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:CAH94353.1};
GN   ORFNames=SG7F10.32c {ECO:0000313|EMBL:CAH94353.1};
OS   Streptomyces griseus subsp. griseus.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=67263 {ECO:0000313|EMBL:CAH94353.1};
RN   [1] {ECO:0000313|EMBL:CAH94353.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=DSM 40236 {ECO:0000313|EMBL:CAH94353.1};
RA   van der Geize R., Dijkhuizen L., Wellington E.M., Piepersberg W.;
RT   "Cloning and heterologous expression of the str/sts-gene cluster from a
RT   Streptomyces griseus DSM40236 PAC library: the cluster for streptomycin
RT   production lies in a highly conserved genomic area.";
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC       {ECO:0000256|ARBA:ARBA00005086}.
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DR   EMBL; AJ862840; CAH94353.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q53IC0; -.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR022694; 3-OHacyl-CoA_DH.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   PIRSF; PIRSF000105; HCDH; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          47..226
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          229..325
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            182
FT                   /note="Important for catalytic activity"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000105-1"
SQ   SEQUENCE   325 AA;  34838 MW;  8257AB36387151E6 CRC64;
     MTRGTSGSAF GVTSWGRGGH RNHTGPCDTE NSERHEVTDL MADIARVGVV GCGQMGAGIA
     EVCARSGLEV KVAETTGEAL EIGRTRLHNS LSKAAERGKI SAAERDETLG RLSFTTDLGE
     FADRDLVIEA VVENEQVKTE IFQVLDQVVT RQDAILASNT SSIPLVKLAV ATSRPDQVIG
     IHFFNPAPVQ KLVELIPALT TSDETIARAE AVVQDVLGKH PIRAQDRSGF VVNALLIPYL
     LSAIRMFESG IASREDIDNG MEMGCAHPMG PLKLADLIGL DTVASVADSM YAEYKEPLYA
     APPLLQRMVD AGRLGRKTGS GFYAY
//