ID Q53TH5_HUMAN Unreviewed; 290 AA.
AC Q53TH5;
DT 24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 24-MAY-2005, sequence version 1.
DT 24-JAN-2024, entry version 64.
DE RecName: Full=Origin recognition complex subunit 4 {ECO:0000256|ARBA:ARBA00019083};
DE Flags: Fragment;
GN Name=ORC4L {ECO:0000313|EMBL:AAX93051.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAX93051.1};
RN [1] {ECO:0000313|EMBL:AAX93051.1}
RP NUCLEOTIDE SEQUENCE.
RA Lamar B., Drone K., LaPlant Y., Gibson A.;
RT "The sequence of Homo sapiens BAC clone RP11-295N18.";
RL Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAX93051.1}
RP NUCLEOTIDE SEQUENCE.
RA Waterston R.H.;
RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AAX93051.1}
RP NUCLEOTIDE SEQUENCE.
RA Waterston R.;
RL Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:AAX93051.1}
RP NUCLEOTIDE SEQUENCE.
RA Wilson R.K.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ORC4 family.
CC {ECO:0000256|ARBA:ARBA00005334}.
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DR EMBL; AC009480; AAX93051.1; -; Genomic_DNA.
DR AlphaFoldDB; Q53TH5; -.
DR PeptideAtlas; Q53TH5; -.
DR ChiTaRS; ORC4; human.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000808; C:origin recognition complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR016527; ORC4.
DR InterPro; IPR032705; ORC4_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12087; ORIGIN RECOGNITION COMPLEX SUBUNIT 4; 1.
DR PANTHER; PTHR12087:SF0; ORIGIN RECOGNITION COMPLEX SUBUNIT 4; 1.
DR Pfam; PF14629; ORC4_C; 1.
DR PIRSF; PIRSF007858; ORC4; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 82..269
FT /note="Origin recognition complex subunit 4 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14629"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAX93051.1"
SQ SEQUENCE 290 AA; 33935 MW; 46C58CF595223037 CRC64;
DRTSSCPVIF ILDEFDLFAH HKNQTLLYNL FDISQSAQTP IAVIGLTCRL DILELLEKRV
KSRFSHRQIH LMNSFGFPQY VKIFKEQLSL PAEFPDKVFA EKWNENVQYL SEDRSVQEVL
QKHFNISKNL RSLHMLLMLA LNRVTASHPF MTAVDLMEAS QLCSMDSKAN IVHGLSVLEI
CLIIAMKHLN DIYEEEPFNF QMVYNEFQKF VQRKAHSVYN FEKPVVMKAF EHLQQLELIK
PMERTSGNSQ REYQLMKLLL DNTQIMNALQ KYPNCPTDVR QWATSSLSWL
//
