ID Q53ZT0_DROME Unreviewed; 334 AA.
AC Q53ZT0;
DT 24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 156.
DE SubName: Full=DNAJ-1 {ECO:0000313|EMBL:AAP31280.1};
DE SubName: Full=DnaJ-like-1, isoform B {ECO:0000313|EMBL:AAN12104.1};
GN Name=DnaJ-1 {ECO:0000313|EMBL:AAP31280.1,
GN ECO:0000313|FlyBase:FBgn0263106};
GN Synonyms=anon-WO0140519.166 {ECO:0000313|EMBL:AAN12104.1},
GN anon-WO0172774.135 {ECO:0000313|EMBL:AAN12104.1}, dhdj-1
GN {ECO:0000313|EMBL:AAN12104.1}, dHDJ1 {ECO:0000313|EMBL:AAN12104.1},
GN dHdj1 {ECO:0000313|EMBL:AAN12104.1}, dhdJ1
GN {ECO:0000313|EMBL:AAN12104.1}, dhdj1 {ECO:0000313|EMBL:AAN12104.1},
GN dHDJ1/HSP40 {ECO:0000313|EMBL:AAN12104.1}, dHSP40
GN {ECO:0000313|EMBL:AAN12104.1}, Dmel\CG10578
GN {ECO:0000313|EMBL:AAN12104.1}, DmHsp40 {ECO:0000313|EMBL:AAN12104.1},
GN DNAJ-1 {ECO:0000313|EMBL:AAN12104.1}, Dnaj-1
GN {ECO:0000313|EMBL:AAN12104.1}, dnaJ-1 {ECO:0000313|EMBL:AAN12104.1},
GN dnaj-1 {ECO:0000313|EMBL:AAN12104.1}, DNAJ1
GN {ECO:0000313|EMBL:AAN12104.1}, DnaJ1 {ECO:0000313|EMBL:AAN12104.1},
GN DnaJ1 64EF {ECO:0000313|EMBL:AAN12104.1}, DROJ1
GN {ECO:0000313|EMBL:AAN12104.1}, DroJ1 {ECO:0000313|EMBL:AAN12104.1},
GN droj1 {ECO:0000313|EMBL:AAN12104.1}, EU3500
GN {ECO:0000313|EMBL:AAN12104.1}, Hdj1 {ECO:0000313|EMBL:AAN12104.1},
GN Hsp-40 {ECO:0000313|EMBL:AAN12104.1}, HSP40
GN {ECO:0000313|EMBL:AAN12104.1}, Hsp40 {ECO:0000313|EMBL:AAN12104.1},
GN hsp40 {ECO:0000313|EMBL:AAN12104.1}, HSP40/HDJ1
GN {ECO:0000313|EMBL:AAN12104.1};
GN ORFNames=CG10578 {ECO:0000313|EMBL:AAN12104.1,
GN ECO:0000313|FlyBase:FBgn0263106}, Dmel_CG10578
GN {ECO:0000313|EMBL:AAN12104.1};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAP31280.1};
RN [1] {ECO:0000313|EMBL:AAN12104.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [3] {ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [5] {ECO:0000313|EMBL:AAN12104.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [6] {ECO:0000313|EMBL:AAP31280.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=3CPA113 {ECO:0000313|EMBL:AAP31287.1}, 3CPA120
RC {ECO:0000313|EMBL:AAP31288.1}, 3CPA126 {ECO:0000313|EMBL:AAP31280.1},
RC 3CPA2 {ECO:0000313|EMBL:AAP31286.1}, 3CPA43
RC {ECO:0000313|EMBL:AAP31285.1}, 3CPA47 {ECO:0000313|EMBL:AAP31281.1},
RC 3CPA61 {ECO:0000313|EMBL:AAP31282.1}, 3CPA81
RC {ECO:0000313|EMBL:AAP31284.1}, 3CPA86 {ECO:0000313|EMBL:AAP31283.1},
RC and Z {ECO:0000313|EMBL:AAP31278.1};
RA Bettencourt B.R., Lerman D.N., Feder M.E.;
RT "Escaping gene conversion: Adaptive molecular evolution of Hsp70 trans-
RT regulators.";
RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:AAN12104.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [8] {ECO:0000313|EMBL:AAN12104.1}
RP NUCLEOTIDE SEQUENCE.
RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S.,
RA Svirskas R., Rubin G.;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN [9] {ECO:0000313|EMBL:AAN12104.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [10] {ECO:0000313|EMBL:AAN12104.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
RN [11] {ECO:0000313|EMBL:AAN12104.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26109357; DOI=.1534/g3.115.018929;
RG FlyBase Consortium;
RA Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., St Pierre S.E.,
RA Gramates L.S., Zhou P., Schroeder A.J., Falls K., Strelets V., Russo S.M.,
RA Gelbart W.M., null;
RT "Gene Model Annotations for Drosophila melanogaster: Impact of High-
RT Throughput Data.";
RL G3 (Bethesda) 5:1721-1736(2015).
RN [12] {ECO:0000313|EMBL:AAN12104.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26109356; DOI=.1534/g3.115.018937;
RG FlyBase Consortium;
RA Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., St Pierre S.E.,
RA Zhou P., Schroeder A.J., Falls K., Emmert D.B., Russo S.M., Gelbart W.M.,
RA null;
RT "Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.";
RL G3 (Bethesda) 5:1737-1749(2015).
RN [13] {ECO:0000313|EMBL:AAN12104.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25589440;
RA Hoskins R.A., Carlson J.W., Wan K.H., Park S., Mendez I., Galle S.E.,
RA Booth B.W., Pfeiffer B.D., George R.A., Svirskas R., Krzywinski M.,
RA Schein J., Accardo M.C., Damia E., Messina G., Mendez-Lago M.,
RA de Pablos B., Demakova O.V., Andreyeva E.N., Boldyreva L.V., Marra M.,
RA Carvalho A.B., Dimitri P., Villasante A., Zhimulev I.F., Rubin G.M.,
RA Karpen G.H., Celniker S.E.;
RT "The Release 6 reference sequence of the Drosophila melanogaster genome.";
RL Genome Res. 25:445-458(2015).
RN [14] {ECO:0000313|EMBL:AAN12104.1}
RP NUCLEOTIDE SEQUENCE.
RG Berkeley Drosophila Genome Project;
RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R.,
RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C.,
RA Rubin G.;
RT "Drosophila melanogaster release 4 sequence.";
RL Submitted (NOV-2022) to the EMBL/GenBank/DDBJ databases.
RN [15] {ECO:0000313|EMBL:AAN12104.1}
RP NUCLEOTIDE SEQUENCE.
RG FlyBase;
RL Submitted (NOV-2022) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AE014296; AAN12104.1; -; Genomic_DNA.
DR EMBL; AY274355; AAP31278.1; -; Genomic_DNA.
DR EMBL; AY274357; AAP31280.1; -; Genomic_DNA.
DR EMBL; AY274358; AAP31281.1; -; Genomic_DNA.
DR EMBL; AY274359; AAP31282.1; -; Genomic_DNA.
DR EMBL; AY274360; AAP31283.1; -; Genomic_DNA.
DR EMBL; AY274361; AAP31284.1; -; Genomic_DNA.
DR EMBL; AY274362; AAP31285.1; -; Genomic_DNA.
DR EMBL; AY274363; AAP31286.1; -; Genomic_DNA.
DR EMBL; AY274364; AAP31287.1; -; Genomic_DNA.
DR EMBL; AY274365; AAP31288.1; -; Genomic_DNA.
DR RefSeq; NP_523936.2; NM_079212.4.
DR RefSeq; NP_729086.1; NM_168128.3.
DR AlphaFoldDB; Q53ZT0; -.
DR SMR; Q53ZT0; -.
DR DNASU; 38643; -.
DR EnsemblMetazoa; FBtr0077123; FBpp0076829; FBgn0263106.
DR EnsemblMetazoa; FBtr0077124; FBpp0076830; FBgn0263106.
DR GeneID; 38643; -.
DR KEGG; dme:Dmel_CG10578; -.
DR UCSC; CG10578-RB; d. melanogaster.
DR AGR; FB:FBgn0263106; -.
DR CTD; 38643; -.
DR FlyBase; FBgn0263106; DnaJ-1.
DR VEuPathDB; VectorBase:FBgn0263106; -.
DR GeneTree; ENSGT00940000170854; -.
DR HOGENOM; CLU_017633_0_0_1; -.
DR OMA; TNEIFMN; -.
DR OrthoDB; 2785358at2759; -.
DR BioGRID-ORCS; 38643; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 38643; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0263106; Expressed in spermathecum and 50 other cell types or tissues.
DR ExpressionAtlas; Q53ZT0; baseline and differential.
DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR GO; GO:0006457; P:protein folding; IEA:InterPro.
DR CDD; cd06257; DnaJ; 1.
DR CDD; cd10747; DnaJ_C; 1.
DR Gene3D; 1.10.287.110; DnaJ domain; 1.
DR Gene3D; 2.60.260.20; Urease metallochaperone UreE, N-terminal domain; 2.
DR InterPro; IPR002939; DnaJ_C.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR018253; DnaJ_domain_CS.
DR InterPro; IPR008971; HSP40/DnaJ_pept-bd.
DR InterPro; IPR036869; J_dom_sf.
DR PANTHER; PTHR24078:SF579; DNAJ HOMOLOG SUBFAMILY B MEMBER 5; 1.
DR PANTHER; PTHR24078; DNAJ HOMOLOG SUBFAMILY C MEMBER; 1.
DR Pfam; PF00226; DnaJ; 1.
DR Pfam; PF01556; DnaJ_C; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SUPFAM; SSF46565; Chaperone J-domain; 1.
DR SUPFAM; SSF49493; HSP40/DnaJ peptide-binding domain; 2.
DR PROSITE; PS00636; DNAJ_1; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q53ZT0};
KW Reference proteome {ECO:0000313|Proteomes:UP000000803}.
FT DOMAIN 4..68
FT /note="J"
FT /evidence="ECO:0000259|PROSITE:PS50076"
SQ SEQUENCE 334 AA; 37028 MW; 60542ABFD47A5689 CRC64;
MGKDFYKILG LERKASDDEI KKAYRKLALK YHPDKNKSPQ AEERFKEIAE AYEVLSDKKK
RDIFDNYGED GLKGGQPGPD GGGQPGAYTY QFHGDPRATF AQFFGSSDPF GAFFTGGDNM
FSGGQGGNTN EIFWNIGGDD MFAFNAQAPS RKRQQDPPIE HDLFVSLEEV DKGCIKKMKI
SRMATGSNGP YKEEKVLRIT VKPGWKAGTK ITFPQEGDSA PNKTPADIVF IIRDKPHSLF
KREGIDLKYT AQISLKQALC GALVSVPTLQ GSRIQVNPNH EIIKPTTTRR INGLGLPVPK
EPSRRGDLIV SFDIKFPDTL APSLQNQLSE LLPN
//
