UniProt: Q549H9

Database: UniProt
Entry: Q549H9_HUMAN

LinkDB:  Q549H9_HUMAN 
Original site:  Q549H9_HUMAN

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Ontology (3)   
   GO (3)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (8)   
   RefSeq(pep) (8)   
DNA sequence (5)   
   EMBL (5)   
Protein domain (2)   
   InterPro (1)   
   Pfam (1)   
Literature (2)   
   PubMed (2)   
All databases (22)   

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ID   Q549H9_HUMAN            Unreviewed;        76 AA.
AC   Q549H9;
DT   24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT   24-MAY-2005, sequence version 1.
DT   27-MAR-2024, entry version 157.
DE   RecName: Full=cAMP-dependent protein kinase inhibitor {ECO:0000256|PIRNR:PIRNR001667};
GN   Name=PKIG {ECO:0000313|EMBL:AAI04257.1};
GN   ORFNames=hCG_38104 {ECO:0000313|EMBL:EAW75908.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAP97238.1};
RN   [1] {ECO:0000313|EMBL:AAP97238.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Zhang X.N., Yu L., Jin L., Hu P.R., Chen S.Y., Zhao S.Y.;
RL   Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EAW75908.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=11181995; DOI=10.1126/science.1058040;
RA   Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G.,
RA   Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P.,
RA   Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.,
RA   Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J.,
RA   Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J.,
RA   McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C.,
RA   Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M.,
RA   Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C.,
RA   Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K.,
RA   Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R.,
RA   Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K.,
RA   Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P.,
RA   Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y.,
RA   Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N.,
RA   Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B.,
RA   Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J.,
RA   Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W.,
RA   Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S.,
RA   Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T.,
RA   Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I.,
RA   Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L.,
RA   Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L.,
RA   Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C.,
RA   Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C.,
RA   Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D.,
RA   McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B.,
RA   Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M.,
RA   Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C.,
RA   Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S.,
RA   Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S.,
RA   Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R.,
RA   Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B.,
RA   Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S.,
RA   Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S.,
RA   Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J.,
RA   Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M.,
RA   Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S.,
RA   Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M.,
RA   Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J.,
RA   Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J.,
RA   Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N.,
RA   Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J.,
RA   Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E.,
RA   Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.;
RT   "The sequence of the human genome.";
RL   Science 291:1304-1351(2001).
RN   [3] {ECO:0000313|EMBL:AAP97238.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Jin L., Yu L., Gao J., Fan Y.X., Xu Y.F., Zhao S.Y.;
RT   "Cloning and characterization of a new human cDNA homologous to murine
RT   protein kinase inhibitor gamma (PKIg) mRNA.";
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:AAI04257.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5] {ECO:0000313|EMBL:EAW75908.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:BAG34984.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Testis {ECO:0000313|EMBL:BAG34984.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y.,
RA   Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R.,
RA   Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N.,
RA   Isogai T.;
RT   "NEDO functional analysis of protein and research application project.";
RL   Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Extremely potent competitive inhibitor of cAMP-dependent
CC       protein kinase activity, this protein interacts with the catalytic
CC       subunit of the enzyme after the cAMP-induced dissociation of its
CC       regulatory chains. {ECO:0000256|ARBA:ARBA00002844}.
CC   -!- INTERACTION:
CC       Q549H9; P50222: MEOX2; NbExp=3; IntAct=EBI-10243311, EBI-748397;
CC   -!- SIMILARITY: Belongs to the PKI family. {ECO:0000256|ARBA:ARBA00006393,
CC       ECO:0000256|PIRNR:PIRNR001667}.
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DR   EMBL; BC104256; AAI04257.1; -; mRNA.
DR   EMBL; BC104257; AAI04258.1; -; mRNA.
DR   EMBL; AF115966; AAP97238.1; -; mRNA.
DR   EMBL; AK312048; BAG34984.1; -; mRNA.
DR   EMBL; CH471077; EAW75908.1; -; Genomic_DNA.
DR   RefSeq; NP_001268373.1; NM_001281444.1.
DR   RefSeq; NP_001268374.1; NM_001281445.1.
DR   RefSeq; NP_008997.1; NM_007066.4.
DR   RefSeq; NP_861520.1; NM_181804.2.
DR   RefSeq; NP_861521.1; NM_181805.2.
DR   RefSeq; XP_016883103.1; XM_017027614.1.
DR   RefSeq; XP_016883104.1; XM_017027615.1.
DR   RefSeq; XP_016883105.1; XM_017027616.1.
DR   IntAct; Q549H9; 1.
DR   Antibodypedia; 27423; 76 antibodies from 18 providers.
DR   DNASU; 11142; -.
DR   GeneID; 11142; -.
DR   KEGG; hsa:11142; -.
DR   CTD; 11142; -.
DR   PharmGKB; PA33351; -.
DR   VEuPathDB; HostDB:ENSG00000168734; -.
DR   HOGENOM; CLU_163471_2_0_1; -.
DR   OMA; CNESACH; -.
DR   OrthoDB; 3991472at2759; -.
DR   BioGRID-ORCS; 11142; 17 hits in 1154 CRISPR screens.
DR   ChiTaRS; PKIG; human.
DR   GenomeRNAi; 11142; -.
DR   ExpressionAtlas; Q549H9; baseline and differential.
DR   GO; GO:0004862; F:cAMP-dependent protein kinase inhibitor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042308; P:negative regulation of protein import into nucleus; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   InterPro; IPR004171; cAMP_dep_PKI.
DR   PANTHER; PTHR15416:SF5; CAMP-DEPENDENT PROTEIN KINASE INHIBITOR GAMMA; 1.
DR   PANTHER; PTHR15416; CAMP-DEPENDENT PROTEIN KINASE INHIBITOR/PKI; 1.
DR   Pfam; PF02827; PKI; 1.
DR   PIRSF; PIRSF001667; PKI; 1.
PE   1: Evidence at protein level;
KW   Protein kinase inhibitor {ECO:0000256|PIRNR:PIRNR001667}.
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          44..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        62..76
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            16
FT                   /note="Important for inhibition"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001667-1"
FT   SITE            19
FT                   /note="Important for inhibition"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001667-1"
FT   SITE            20
FT                   /note="Important for inhibition"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001667-1"
SQ   SEQUENCE   76 AA;  7910 MW;  F01B4C73ED2CC6EE CRC64;
     MMEVESSYSD FISCDRTGRR NAVPDIQGDS EAVSVRKLAG DMGELALEGA EGQVEGSAPD
     KEAGNQPQSS DGTTSS
//

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