ID DYRK2_DICDI Reviewed; 915 AA.
AC Q54BC9;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 01-MAY-2013, entry version 60.
DE RecName: Full=Probable serine/threonine-protein kinase dyrk2;
DE EC=2.7.12.1;
DE AltName: Full=Dual specificity tyrosine-phosphorylation-regulated kinase 2;
GN Name=dyrk2; ORFNames=DDB_G0293750;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A.,
RA Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q.,
RA Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F.,
RA Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P.,
RA Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P.,
RA Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N.,
RA Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M.,
RA Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I.,
RA Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R.,
RA Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C.,
RA Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D.,
RA Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S.,
RA Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T.,
RA Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A.,
RA Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M.,
RA Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G.,
RA Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CMGC
CC Ser/Thr protein kinase family. MNB/DYRK subfamily.
CC -!- SIMILARITY: Contains 1 protein kinase domain.
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DR EMBL; AAFI02000219; EAL60552.1; -; Genomic_DNA.
DR RefSeq; XP_628965.1; XM_628963.1.
DR HSSP; P49761; 2EXE.
DR ProteinModelPortal; Q54BC9; -.
DR EnsemblProtists; DDB0230102; DDB0230102; DDB_G0293750.
DR GeneID; 8629393; -.
DR KEGG; ddi:DDB_G0293750; -.
DR dictyBase; DDB_G0293750; dyrk2.
DR eggNOG; COG0515; -.
DR InParanoid; Q54BC9; -.
DR KO; K08825; -.
DR OMA; CFENERI; -.
DR ProtClustDB; CLSZ2846555; -.
DR GO; GO:0005737; C:cytoplasm; ISS:dictyBase.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0004712; F:protein serine/threonine/tyrosine kinase activity; IEA:EC.
DR GO; GO:0006468; P:protein phosphorylation; ISS:dictyBase.
DR InterPro; IPR011009; Kinase-like_dom.
DR InterPro; IPR000719; Prot_kinase_cat_dom.
DR InterPro; IPR002290; Ser/Thr_dual-sp_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Kinase_like; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Kinase; Nucleotide-binding;
KW Reference proteome; Serine/threonine-protein kinase; Transferase.
FT CHAIN 1 915 Probable serine/threonine-protein kinase
FT dyrk2.
FT /FTId=PRO_0000362010.
FT DOMAIN 605 902 Protein kinase.
FT NP_BIND 611 619 ATP (By similarity).
FT COMPBIAS 58 64 Poly-Asn.
FT COMPBIAS 65 77 Poly-Thr.
FT COMPBIAS 170 182 Poly-Ser.
FT COMPBIAS 194 204 Poly-Ser.
FT COMPBIAS 207 210 Poly-Asn.
FT COMPBIAS 295 298 Poly-Pro.
FT COMPBIAS 299 302 Poly-Ser.
FT COMPBIAS 303 318 Poly-Thr.
FT COMPBIAS 319 325 Poly-Ser.
FT COMPBIAS 378 391 Poly-Ser.
FT COMPBIAS 439 445 Poly-Thr.
FT COMPBIAS 448 462 Poly-Ser.
FT COMPBIAS 466 472 Poly-Ser.
FT COMPBIAS 488 499 Poly-Thr.
FT COMPBIAS 514 531 Poly-Thr.
FT ACT_SITE 731 731 Proton acceptor (By similarity).
FT BINDING 634 634 ATP (By similarity).
SQ SEQUENCE 915 AA; 98276 MW; A7BFF787F80278D6 CRC64;
MTSLHKQIIE SHNNDITKLK SSMSTRAAAR RSVCLSSMSY TLGADDVTPI TSNTTPSNNN
NNNNTTTTIT TTTTTPTISP LKQSTTGSII PKSILVTKSG SKEEPIVSSS KSSSNSSSIN
NNFNNLYSAS TFSSSTKKVH ERPSINPGFR KPREALLSGN SDSGIIKKPS SSSTSSSSSS
SSTTSNIKAP IQISHSSNSG SSSSGGNNNN SDDNSGSSTI KHTAASLSKM KLSPSHTISD
SPRSSTMKSR SVSISNGSLF SPTNTSVNNS NNNTSSNIKT PTKSSISENL DQNTPPPPSS
SSTTKTPTAT TTTTTTTTSS SSSTSTNTTP SKSSVDDVFA RLANVSKPAI KSRSLSVSAS
LARVEQSPPT KDKGDKESSS SSSSSSSSFS SKFTKILRSS SKTPTPTSSN TTVQPSTTSL
SASKISSRKD TKSLSSFSTT TTTTTLKSSS SSSSSSSSSS KSNIASSSSS SSNNLTNLLT
QSQSISSTST STTTTPTSTS PTLASSMSVL SSPTSTTTTS TSTTSTTTTP TKSSCTIITP
SIALKLYIND LTSAEQSEIL DYPQIYFTGN TNKKTKFNSQ LPNNGYDNDI GEYKVVERDH
IAYRFEIVSI LGQGSFCQVV KGYDYKTGEM VALKILRNQK RFHNQALTEI KILEYLKTND
PNSTASIVHL NNYFYFRNHL ILTFELLSMN LYDFLKVNHF QGYNLNLVRR FGAQILTSLR
FLSKRNIIHA DLKPENILLK SPTKSGIKLI DFGSSCFENE QIFTYIQSRF YRSPEVILGT
KYDKSIDIWS LGCILVEIFT GVPLFPGSDE PEQLACIMEV LGAPPKSVID NSTRKDIFFE
DDGTPKPVKN STTGELYTIG TKSFKDSIRS GDEDFDNFIL DCLKWEPSQR ITAEQGLKHD
WIIKVIAPTA PSTPS
//
