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Database: UniProt
Entry: Q54BC9
LinkDB: Q54BC9
Original site: Q54BC9 
ID   DYRK2_DICDI             Reviewed;         915 AA.
AC   Q54BC9;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   01-OCT-2014, entry version 70.
DE   RecName: Full=Probable serine/threonine-protein kinase dyrk2;
DE            EC=2.7.12.1;
DE   AltName: Full=Dual specificity tyrosine-phosphorylation-regulated kinase 2;
GN   Name=dyrk2; ORFNames=DDB_G0293750;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A.,
RA   Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q.,
RA   Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F.,
RA   Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P.,
RA   Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P.,
RA   Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N.,
RA   Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M.,
RA   Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I.,
RA   Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R.,
RA   Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C.,
RA   Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D.,
RA   Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S.,
RA   Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T.,
RA   Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A.,
RA   Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M.,
RA   Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G.,
RA   Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. CMGC
CC       Ser/Thr protein kinase family. MNB/DYRK subfamily. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC       {ECO:0000255|PROSITE-ProRule:PRU00159}.
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DR   EMBL; AAFI02000219; EAL60552.1; -; Genomic_DNA.
DR   RefSeq; XP_628965.1; XM_628963.1.
DR   ProteinModelPortal; Q54BC9; -.
DR   STRING; 44689.DDB_0230102; -.
DR   EnsemblProtists; DDB0230102; DDB0230102; DDB_G0293750.
DR   GeneID; 8629393; -.
DR   KEGG; ddi:DDB_G0293750; -.
DR   dictyBase; DDB_G0293750; dyrk2.
DR   eggNOG; COG0515; -.
DR   InParanoid; Q54BC9; -.
DR   KO; K08825; -.
DR   OMA; ERDHIAY; -.
DR   GO; GO:0005737; C:cytoplasm; ISS:dictyBase.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004712; F:protein serine/threonine/tyrosine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006468; P:protein phosphorylation; ISS:dictyBase.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR002290; Ser/Thr_dual-sp_kinase_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Kinase; Nucleotide-binding;
KW   Reference proteome; Serine/threonine-protein kinase; Transferase.
FT   CHAIN         1    915       Probable serine/threonine-protein kinase
FT                                dyrk2.
FT                                /FTId=PRO_0000362010.
FT   DOMAIN      605    902       Protein kinase. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00159}.
FT   NP_BIND     611    619       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00159}.
FT   COMPBIAS     58     64       Poly-Asn.
FT   COMPBIAS     65     77       Poly-Thr.
FT   COMPBIAS    170    182       Poly-Ser.
FT   COMPBIAS    194    204       Poly-Ser.
FT   COMPBIAS    207    210       Poly-Asn.
FT   COMPBIAS    295    298       Poly-Pro.
FT   COMPBIAS    299    302       Poly-Ser.
FT   COMPBIAS    303    318       Poly-Thr.
FT   COMPBIAS    319    325       Poly-Ser.
FT   COMPBIAS    378    391       Poly-Ser.
FT   COMPBIAS    439    445       Poly-Thr.
FT   COMPBIAS    448    462       Poly-Ser.
FT   COMPBIAS    466    472       Poly-Ser.
FT   COMPBIAS    488    499       Poly-Thr.
FT   COMPBIAS    514    531       Poly-Thr.
FT   ACT_SITE    731    731       Proton acceptor. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00159, ECO:0000255|PROSITE-
FT                                ProRule:PRU10027}.
FT   BINDING     634    634       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00159}.
SQ   SEQUENCE   915 AA;  98276 MW;  A7BFF787F80278D6 CRC64;
     MTSLHKQIIE SHNNDITKLK SSMSTRAAAR RSVCLSSMSY TLGADDVTPI TSNTTPSNNN
     NNNNTTTTIT TTTTTPTISP LKQSTTGSII PKSILVTKSG SKEEPIVSSS KSSSNSSSIN
     NNFNNLYSAS TFSSSTKKVH ERPSINPGFR KPREALLSGN SDSGIIKKPS SSSTSSSSSS
     SSTTSNIKAP IQISHSSNSG SSSSGGNNNN SDDNSGSSTI KHTAASLSKM KLSPSHTISD
     SPRSSTMKSR SVSISNGSLF SPTNTSVNNS NNNTSSNIKT PTKSSISENL DQNTPPPPSS
     SSTTKTPTAT TTTTTTTTSS SSSTSTNTTP SKSSVDDVFA RLANVSKPAI KSRSLSVSAS
     LARVEQSPPT KDKGDKESSS SSSSSSSSFS SKFTKILRSS SKTPTPTSSN TTVQPSTTSL
     SASKISSRKD TKSLSSFSTT TTTTTLKSSS SSSSSSSSSS KSNIASSSSS SSNNLTNLLT
     QSQSISSTST STTTTPTSTS PTLASSMSVL SSPTSTTTTS TSTTSTTTTP TKSSCTIITP
     SIALKLYIND LTSAEQSEIL DYPQIYFTGN TNKKTKFNSQ LPNNGYDNDI GEYKVVERDH
     IAYRFEIVSI LGQGSFCQVV KGYDYKTGEM VALKILRNQK RFHNQALTEI KILEYLKTND
     PNSTASIVHL NNYFYFRNHL ILTFELLSMN LYDFLKVNHF QGYNLNLVRR FGAQILTSLR
     FLSKRNIIHA DLKPENILLK SPTKSGIKLI DFGSSCFENE QIFTYIQSRF YRSPEVILGT
     KYDKSIDIWS LGCILVEIFT GVPLFPGSDE PEQLACIMEV LGAPPKSVID NSTRKDIFFE
     DDGTPKPVKN STTGELYTIG TKSFKDSIRS GDEDFDNFIL DCLKWEPSQR ITAEQGLKHD
     WIIKVIAPTA PSTPS
//
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