ID DAA10_DICDI Reviewed; 357 AA.
AC Q54E33;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 24-JAN-2024, entry version 98.
DE RecName: Full=Dynein axonemal assembly factor 10 {ECO:0000305};
DE AltName: Full=WD repeat-containing protein 92 homolog;
GN Name=dnaaf10; Synonyms=wdr92; ORFNames=DDB_G0291822;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Key assembly factor specifically required for the stability
CC of axonemal dynein heavy chains in cytoplasm.
CC {ECO:0000250|UniProtKB:A8J3F6}.
CC -!- SUBUNIT: Interacts with PIH1D1; the interaction associates DNAAF10 with
CC the R2TP complex (By similarity). Interacts with several dynein
CC axonemal assembly factors (By similarity).
CC {ECO:0000250|UniProtKB:A8J3F6, ECO:0000250|UniProtKB:Q96MX6}.
CC -!- SUBCELLULAR LOCATION: Dynein axonemal particle
CC {ECO:0000250|UniProtKB:A8J3F6}.
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DR EMBL; AAFI02000185; EAL61532.1; -; Genomic_DNA.
DR RefSeq; XP_629954.1; XM_629952.1.
DR AlphaFoldDB; Q54E33; -.
DR SMR; Q54E33; -.
DR STRING; 44689.Q54E33; -.
DR PaxDb; 44689-DDB0267167; -.
DR EnsemblProtists; EAL61532; EAL61532; DDB_G0291822.
DR GeneID; 8628360; -.
DR KEGG; ddi:DDB_G0291822; -.
DR dictyBase; DDB_G0291822; wdr92.
DR eggNOG; ENOG502QRKB; Eukaryota.
DR HOGENOM; CLU_062543_0_0_1; -.
DR InParanoid; Q54E33; -.
DR OMA; WSICTND; -.
DR PhylomeDB; Q54E33; -.
DR PRO; PR:Q54E33; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0120293; C:dynein axonemal particle; ISS:UniProtKB.
DR GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR10971:SF2; DYNEIN AXONEMAL ASSEMBLY FACTOR 10; 1.
DR PANTHER; PTHR10971; MRNA EXPORT FACTOR AND BUB3; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..357
FT /note="Dynein axonemal assembly factor 10"
FT /id="PRO_0000328014"
FT REPEAT 80..127
FT /note="WD 1"
FT REPEAT 132..170
FT /note="WD 2"
FT REPEAT 184..223
FT /note="WD 3"
FT REPEAT 277..321
FT /note="WD 4"
SQ SEQUENCE 357 AA; 39692 MW; A2E06D106A140BFA CRC64;
MSALGESNNK QNGKEILHNY VTKKLTSQPY SCQWIPTSCS VVTVGKKTSG GISKGDIKIH
QLEFDDTSGD PKLNLVYENE FTNPFRCLSF FKQANQLQQQ DNRKFITGDF NGQISEWDSD
ICDIPIWGVK GAHQGSISAI DAYADNLVVC GGKDGTIKVY DTRIKPNSAN DNNGNNSSPI
STFEQTNKSN CWSICTNDNN IIAGFENGDL NIYNLKTNSI QSTTKLNGGI CSIDSNDRSN
ILNQFLITTN KSFISIASFN NNNNNNIEFK DYDINKEPNQ TIWSGIYSPW NKKDNENIFT
IAQGDGSVSM YRDDCKLIDK VLVSDLPILS LDYSKDRKGL LCCISLKKQL SILISPC
//
