ID XPO1_DICDI Reviewed; 1057 AA.
AC Q54EV7;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 01-MAY-2013, entry version 56.
DE RecName: Full=Exportin-1;
DE Short=Exp1;
GN Name=xpo1; Synonyms=crm1; ORFNames=DDB_G0291306;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A.,
RA Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q.,
RA Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F.,
RA Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P.,
RA Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P.,
RA Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N.,
RA Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M.,
RA Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I.,
RA Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R.,
RA Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C.,
RA Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D.,
RA Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S.,
RA Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T.,
RA Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A.,
RA Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M.,
RA Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G.,
RA Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Mediates the nuclear export of cellular proteins
CC (cargos) bearing a leucine-rich nuclear export signal (NES).
CC -!- SUBUNIT: Component of a nuclear export receptor complex (By
CC similarity).
CC -!- SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm,
CC perinuclear region (By similarity). Note=Shuttles between the
CC nucleus and the cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the exportin family.
CC -!- SIMILARITY: Contains 11 HEAT repeats.
CC -!- SIMILARITY: Contains 1 importin N-terminal domain.
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DR EMBL; AAFI02000177; EAL61637.2; -; Genomic_DNA.
DR RefSeq; XP_635133.2; XM_630041.2.
DR HSSP; O14980; 1W9C.
DR ProteinModelPortal; Q54EV7; -.
DR STRING; 44689.DDBDRAFT_0183812; -.
DR EnsemblProtists; DDB0234066; DDB0234066; DDB_G0291306.
DR GeneID; 8628079; -.
DR KEGG; ddi:DDB_G0291306; -.
DR dictyBase; DDB_G0291306; xpo1.
DR eggNOG; COG5101; -.
DR KO; K14290; -.
DR OMA; FECTLDM; -.
DR ProtClustDB; CLSZ2429543; -.
DR GO; GO:0005643; C:nuclear pore; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; ISS:dictyBase.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008565; F:protein transporter activity; ISS:dictyBase.
DR GO; GO:0006611; P:protein export from nucleus; ISS:dictyBase.
DR Gene3D; 1.25.10.10; -; 3.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014877; CRM1_C_dom.
DR InterPro; IPR013598; Exportin-1/Importin-b-like.
DR InterPro; IPR001494; Importin-beta_N.
DR Pfam; PF08767; CRM1_C; 1.
DR Pfam; PF03810; IBN_N; 1.
DR Pfam; PF08389; Xpo1; 1.
DR SMART; SM01102; CRM1_C; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; ARM-type_fold; 2.
DR PROSITE; PS50077; HEAT_REPEAT; FALSE_NEG.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 3: Inferred from homology;
KW Complete proteome; Cytoplasm; Nucleus; Protein transport;
KW Reference proteome; Repeat; Translocation; Transport.
FT CHAIN 1 1057 Exportin-1.
FT /FTId=PRO_0000328479.
FT DOMAIN 36 102 Importin N-terminal.
FT REPEAT 239 275 HEAT 1.
FT REPEAT 281 321 HEAT 2.
FT REPEAT 462 501 HEAT 3.
FT REPEAT 506 544 HEAT 4.
FT REPEAT 551 588 HEAT 5.
FT REPEAT 596 633 HEAT 6.
FT REPEAT 739 776 HEAT 7.
FT REPEAT 781 818 HEAT 8.
FT REPEAT 855 892 HEAT 9.
FT REPEAT 902 925 HEAT 10.
FT REPEAT 926 965 HEAT 11.
SQ SEQUENCE 1057 AA; 122014 MW; 2B9B86C8BDF82C69 CRC64;
MENILNFNEP LDINLLDQIV SVLYNPLSNK NDIKAAQMVL GKFQEHPDAW SKVDTILETS
KIVQTKFIAL VIMDSLIKYR WKSLPREQCE GIKNYIVSLI IRLSSDPQTS SREKLLVNKL
NLVFVQILKQ EWTTNWSTFI PEIISSSKTN ESLCENNMVI LRLLSEEIFN FSEEQMTQTK
IQTLKITFEK EFSLINDLCF YILENATRAS LIKATLETLQ RFLNWVPLHY IIEVNGGIAE
PSKLVKLLLH KYFPEPLFRN STLKCLTEIG NLNLGNQQYD AVFIAIIDKF MNQIKFIKPD
PSKIPQDYED GDQGERSFIH TVSLFLTGFF KSHLKIMENS LNIPYLTLAH EILVNISNID
ELELFKICLE YWNFLSSNLY SDIATFTTTL LSTPPRLQLY KSVLSKVRVV LIDHMAKPEE
VIVVEDENGN IVRETTKDTD SLTLYESMRE TLIFLTHLDS ENTQHIMLEK LQTLISGREF
TFQRLNTLCW AIGSISGAQN KEQEKRFLVT VIKDLLELCQ NKKGKDNKAV IASDIMYIVG
QYPRFLKDHW KFLKTVVNKL FEFMHESHPG VQDMACDTFL KISKQCKRKF VVLQVEESQP
FINELLNQLS TTIAHLEQSQ IHTFYEAVGY MIASSSDAAF REKLVNKFME LPNHSWLQIM
GAASVKVESL LTVEVARDIL NLIKTNNRAA MSLENCYITQ ISKIYLDLLN VYRTYSDHIS
RNPNIYRETL GQAMRSVKKE TLKLLETFIE KSSDKQVIYS NFLQPLLEAV LGDYRTNIPE
TRDPEVLSLM TAIITSLKQL VHPEVPKILE AVFETTLSMI TKNFEDYPYH RINFFNLIRA
INSNAFTVFH NLHPQQFKLL IDCVVWAFKH TERNISETGL HILKELIENV SKNSDVANVF
FKTYLVSLLN DILYILTDSF HKSGFALECD ILRMMFQVVE NGVVKIPLFD PQQANFPSNS
EYVKEIVVTF LSASPNVSRP QIQAFVTRLF NLANINNNDF KSATRDFLIT LKEWKSHENA
DLYSDEKNIE KALALKKQSM IPGMVRPNDV NLEMNDL
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