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Database: UniProt
Entry: Q54EV7
LinkDB: Q54EV7
Original site: Q54EV7 
ID   XPO1_DICDI              Reviewed;        1057 AA.
AC   Q54EV7;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   29-OCT-2014, entry version 66.
DE   RecName: Full=Exportin-1;
DE            Short=Exp1;
GN   Name=xpo1; Synonyms=crm1; ORFNames=DDB_G0291306;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A.,
RA   Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q.,
RA   Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F.,
RA   Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P.,
RA   Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P.,
RA   Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N.,
RA   Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M.,
RA   Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I.,
RA   Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R.,
RA   Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C.,
RA   Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D.,
RA   Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S.,
RA   Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T.,
RA   Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A.,
RA   Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M.,
RA   Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G.,
RA   Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Mediates the nuclear export of cellular proteins
CC       (cargos) bearing a leucine-rich nuclear export signal (NES).
CC   -!- SUBUNIT: Component of a nuclear export receptor complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm,
CC       perinuclear region {ECO:0000250}. Note=Shuttles between the
CC       nucleus and the cytoplasm. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 11 HEAT repeats. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 1 importin N-terminal domain.
CC       {ECO:0000255|PROSITE-ProRule:PRU00115}.
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DR   EMBL; AAFI02000177; EAL61637.2; -; Genomic_DNA.
DR   RefSeq; XP_635133.2; XM_630041.2.
DR   ProteinModelPortal; Q54EV7; -.
DR   STRING; 44689.DDBDRAFT_0183812; -.
DR   PRIDE; Q54EV7; -.
DR   EnsemblProtists; DDB0234066; DDB0234066; DDB_G0291306.
DR   GeneID; 8628079; -.
DR   KEGG; ddi:DDB_G0291306; -.
DR   dictyBase; DDB_G0291306; xpo1.
DR   eggNOG; COG5101; -.
DR   InParanoid; Q54EV7; -.
DR   KO; K14290; -.
DR   OMA; ILKQAWP; -.
DR   PhylomeDB; Q54EV7; -.
DR   Reactome; REACT_213265; Cyclin A/B1 associated events during G2/M transition.
DR   PRO; PR:Q54EV7; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; ISS:dictyBase.
DR   GO; GO:0008565; F:protein transporter activity; ISS:dictyBase.
DR   GO; GO:0006611; P:protein export from nucleus; ISS:dictyBase.
DR   Gene3D; 1.25.10.10; -; 3.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014877; CRM1_C_dom.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR001494; Importin-beta_N.
DR   Pfam; PF08767; CRM1_C; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SMART; SM01102; CRM1_C; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 4.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Nucleus; Protein transport;
KW   Reference proteome; Repeat; Translocation; Transport.
FT   CHAIN         1   1057       Exportin-1.
FT                                /FTId=PRO_0000328479.
FT   DOMAIN       36    102       Importin N-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00115}.
FT   REPEAT      239    275       HEAT 1.
FT   REPEAT      281    321       HEAT 2.
FT   REPEAT      462    501       HEAT 3.
FT   REPEAT      506    544       HEAT 4.
FT   REPEAT      551    588       HEAT 5.
FT   REPEAT      596    633       HEAT 6.
FT   REPEAT      739    776       HEAT 7.
FT   REPEAT      781    818       HEAT 8.
FT   REPEAT      855    892       HEAT 9.
FT   REPEAT      902    925       HEAT 10.
FT   REPEAT      926    965       HEAT 11.
SQ   SEQUENCE   1057 AA;  122014 MW;  2B9B86C8BDF82C69 CRC64;
     MENILNFNEP LDINLLDQIV SVLYNPLSNK NDIKAAQMVL GKFQEHPDAW SKVDTILETS
     KIVQTKFIAL VIMDSLIKYR WKSLPREQCE GIKNYIVSLI IRLSSDPQTS SREKLLVNKL
     NLVFVQILKQ EWTTNWSTFI PEIISSSKTN ESLCENNMVI LRLLSEEIFN FSEEQMTQTK
     IQTLKITFEK EFSLINDLCF YILENATRAS LIKATLETLQ RFLNWVPLHY IIEVNGGIAE
     PSKLVKLLLH KYFPEPLFRN STLKCLTEIG NLNLGNQQYD AVFIAIIDKF MNQIKFIKPD
     PSKIPQDYED GDQGERSFIH TVSLFLTGFF KSHLKIMENS LNIPYLTLAH EILVNISNID
     ELELFKICLE YWNFLSSNLY SDIATFTTTL LSTPPRLQLY KSVLSKVRVV LIDHMAKPEE
     VIVVEDENGN IVRETTKDTD SLTLYESMRE TLIFLTHLDS ENTQHIMLEK LQTLISGREF
     TFQRLNTLCW AIGSISGAQN KEQEKRFLVT VIKDLLELCQ NKKGKDNKAV IASDIMYIVG
     QYPRFLKDHW KFLKTVVNKL FEFMHESHPG VQDMACDTFL KISKQCKRKF VVLQVEESQP
     FINELLNQLS TTIAHLEQSQ IHTFYEAVGY MIASSSDAAF REKLVNKFME LPNHSWLQIM
     GAASVKVESL LTVEVARDIL NLIKTNNRAA MSLENCYITQ ISKIYLDLLN VYRTYSDHIS
     RNPNIYRETL GQAMRSVKKE TLKLLETFIE KSSDKQVIYS NFLQPLLEAV LGDYRTNIPE
     TRDPEVLSLM TAIITSLKQL VHPEVPKILE AVFETTLSMI TKNFEDYPYH RINFFNLIRA
     INSNAFTVFH NLHPQQFKLL IDCVVWAFKH TERNISETGL HILKELIENV SKNSDVANVF
     FKTYLVSLLN DILYILTDSF HKSGFALECD ILRMMFQVVE NGVVKIPLFD PQQANFPSNS
     EYVKEIVVTF LSASPNVSRP QIQAFVTRLF NLANINNNDF KSATRDFLIT LKEWKSHENA
     DLYSDEKNIE KALALKKQSM IPGMVRPNDV NLEMNDL
//
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