ID Y0971_DICDI Reviewed; 445 AA.
AC Q54FB9;
DT 20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-APR-2013, entry version 48.
DE RecName: Full=TNF receptor-associated factor family protein DDB_G0290971;
GN ORFNames=DDB_G0290971;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A.,
RA Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q.,
RA Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F.,
RA Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P.,
RA Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P.,
RA Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N.,
RA Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M.,
RA Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I.,
RA Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R.,
RA Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C.,
RA Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D.,
RA Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S.,
RA Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T.,
RA Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A.,
RA Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M.,
RA Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G.,
RA Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Probable adapter protein and signal transducer that
CC links members of the tumor necrosis factor receptor family to
CC different signaling pathways by association with the receptor
CC cytoplasmic domain and kinases (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- DOMAIN: The MATH/TRAF domain binds to receptor cytoplasmic
CC domains.
CC -!- SIMILARITY: Belongs to the TNF receptor-associated factor family.
CC A subfamily.
CC -!- SIMILARITY: Contains 1 MATH domain.
CC -!- SIMILARITY: Contains 1 RING-type zinc finger.
CC -!- SIMILARITY: Contains 2 TRAF-type zinc fingers.
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DR EMBL; AAFI02000174; EAL61916.1; -; Genomic_DNA.
DR RefSeq; XP_635418.1; XM_630326.1.
DR ProteinModelPortal; Q54FB9; -.
DR EnsemblProtists; DDB0189177; DDB0189177; DDB_G0290971.
DR GeneID; 8627919; -.
DR KEGG; ddi:DDB_G0290971; -.
DR dictyBase; DDB_G0290971; -.
DR eggNOG; NOG272717; -.
DR InParanoid; Q54FB9; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.30.40.10; -; 1.
DR Gene3D; 3.90.890.10; -; 1.
DR InterPro; IPR002083; MATH.
DR InterPro; IPR013323; SIAH-type.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR001293; Znf_TRAF.
DR SMART; SM00061; MATH; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF49599; Traf_like; 2.
DR PROSITE; PS50144; MATH; 1.
DR PROSITE; PS00518; ZF_RING_1; FALSE_NEG.
DR PROSITE; PS50089; ZF_RING_2; FALSE_NEG.
DR PROSITE; PS50145; ZF_TRAF; 1.
PE 3: Inferred from homology;
KW Coiled coil; Complete proteome; Cytoplasm; Metal-binding;
KW Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1 445 TNF receptor-associated factor family
FT protein DDB_G0290971.
FT /FTId=PRO_0000393760.
FT DOMAIN 314 441 MATH.
FT ZN_FING 23 67 RING-type; degenerate.
FT ZN_FING 133 186 TRAF-type 1.
FT ZN_FING 186 242 TRAF-type 2.
FT COILED 269 307 Potential.
FT COMPBIAS 32 35 Poly-Ser.
SQ SEQUENCE 445 AA; 51600 MW; 2DED0A17DE457692 CRC64;
MTVKYSINEL LVDHESLSDN FTCPICFDLY YSSSSKKEVF QCRDGHLACK SCWSDSLLNK
KECMICRTPV NSMNELSRNR FIENEFLKKK VYCPNSFFFI ENVNVDDSSM NEALIRDESN
GCKEIITVEA LEKHQVECQF RFEKCPFTGC DKILRLKQIA EHKIDCKFSS KYCLHCDKEI
PGQLDAHALV CPKVRIQCTQ SESCKKSFPR EQLRLHIDQD CKFTIVKCKY CCLNNSKNES
IDFKRFELAD HYEKVNHSFE MDKVINNQQL ELVECKNQIY QINNKYEKLL ERVIKLEQLS
MDASNKLSLL PRFKNSIIFA TFSTHKLKRV NEGISTVPLD VGNNKFKLTL YPNGYDESNK
GNISAYLYRV SINEPAVKVS FTFVFNNQDS RKNRTYRIQE YTFNGGATSG WGYPKTLKTV
DVDSANGWLT DEDKLVIGLR IQVLP
//
