ID SECG_DICDI Reviewed; 986 AA.
AC Q54KA7; P90525;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 120.
DE RecName: Full=Ankyrin repeat, PH and SEC7 domain containing protein secG;
GN Name=secG; ORFNames=DDB_G0287459;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 756-980.
RC STRAIN=AX4;
RA Loomis W.F., Iranfar N.;
RL Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB36958.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAFI02000101; EAL63695.1; -; Genomic_DNA.
DR EMBL; U78755; AAB36958.1; ALT_FRAME; mRNA.
DR RefSeq; XP_637214.1; XM_632122.1.
DR AlphaFoldDB; Q54KA7; -.
DR SMR; Q54KA7; -.
DR STRING; 44689.Q54KA7; -.
DR PaxDb; 44689-DDB0191439; -.
DR EnsemblProtists; EAL63695; EAL63695; DDB_G0287459.
DR GeneID; 8626150; -.
DR KEGG; ddi:DDB_G0287459; -.
DR dictyBase; DDB_G0287459; secG.
DR eggNOG; KOG0930; Eukaryota.
DR eggNOG; KOG4177; Eukaryota.
DR HOGENOM; CLU_302561_0_0_1; -.
DR InParanoid; Q54KA7; -.
DR OMA; FNGRSKC; -.
DR PhylomeDB; Q54KA7; -.
DR PRO; PR:Q54KA7; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0005829; C:cytosol; IDA:dictyBase.
DR GO; GO:0005764; C:lysosome; IDA:dictyBase.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IMP:dictyBase.
DR GO; GO:0031589; P:cell-substrate adhesion; IMP:dictyBase.
DR GO; GO:0006935; P:chemotaxis; IMP:dictyBase.
DR GO; GO:0043327; P:chemotaxis to cAMP; IMP:dictyBase.
DR GO; GO:0031154; P:culmination involved in sorocarp development; IMP:dictyBase.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd01252; PH_GRP1-like; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 4.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR24193:SF121; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24193; ANKYRIN REPEAT PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 5.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 15.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 13.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 2: Evidence at transcript level;
KW ANK repeat; Reference proteome; Repeat.
FT CHAIN 1..986
FT /note="Ankyrin repeat, PH and SEC7 domain containing
FT protein secG"
FT /id="PRO_0000334489"
FT REPEAT 34..63
FT /note="ANK 1"
FT REPEAT 68..97
FT /note="ANK 2"
FT REPEAT 101..131
FT /note="ANK 3"
FT REPEAT 135..164
FT /note="ANK 4"
FT REPEAT 168..197
FT /note="ANK 5"
FT REPEAT 201..230
FT /note="ANK 6"
FT REPEAT 234..263
FT /note="ANK 7"
FT REPEAT 267..296
FT /note="ANK 8"
FT REPEAT 300..329
FT /note="ANK 9"
FT REPEAT 334..363
FT /note="ANK 10"
FT REPEAT 367..396
FT /note="ANK 11"
FT REPEAT 400..429
FT /note="ANK 12"
FT REPEAT 433..462
FT /note="ANK 13"
FT REPEAT 466..495
FT /note="ANK 14"
FT REPEAT 499..528
FT /note="ANK 15"
FT DOMAIN 580..770
FT /note="SEC7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00189"
FT DOMAIN 784..895
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 911..986
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 920..986
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 986 AA; 107523 MW; 3AB5789F4A39788D CRC64;
MGSTSNSTKN TGSTTTTTTT AAPATTAKHS NSAPTRPSVH YYSSTGDIEK LSNLLNNSAT
SPDTPDSEKR TPLHHAAFCG SAACVNFLLD KKANANIKDS AGNTPLQWAS SRGHLECIKL
LVEKGGVDVN TKDDKNGTPL HKASLFASAE CVLYLLNGKA DPRAVTTNGE TPLHHASAGG
NPQCVELLIK ADSKVNAVDN DCITPLHQAS FSGHSSCVSL LLKKGAKVDP RDIHGISPLH
NAASAGYVDC VEQLVRNGEN INCVDIEGVT PLHHTCFNGN LQLTKRLIEL GAKINMVDEM
GETPLHKAAF NGHKEVCEYL LYLDPTMIDC RDSRQSTSLH LAAFNGLLDM VDLLIRYKAQ
INIKDEEGAT PLHKASFNGH SSCAKLLVDK GAPICIVDSQ GATPLHKAAF NGRSKCLATL
IRSGAELEVK DSQGGTPLHN AAYNGHSDCC RILLKKGANV NAVDTHSSTP LHLASAAGAR
DTVDVLIQFK ARIDAKNFAG KTPLVYAIKK NHSDVARVLI RAGADLDQVS LRSSVDFTKT
FGTENHDEIY QIVNKRESSN HEVDELQLAL EQQAKEDMEQ LAAEKQKLLL IKAAIAQFNS
HPKKGIEFIV ANGVISEKNP KEVAHFLLTH SELSKQSIGE YIGEGDDFNL QVLHAFVDEL
NFFGLDFDVA LRKYLLTFRL PGEAQKIDRM MEKFASQFYQ HNPENKVFVN QDAVYVLAFS
VIMLNTDAHN PNIKKKMTKA EFLRNNSGIN SGDDLPPDFM ENLYDKIVTN EIKMERDGNQ
ANQHVEKKGW LTKQGGRIKT WKKRWFILTA NCLLYYKTPQ DHEPCGIIPL ENVVVTIDPQ
KKFCFMLHSS QEQMKACKLN SDGTLVQANH AAYFIAAANM AEMDSWVQSI KSNIHSNPNF
EQLLKRKAET IRGRGKVSTK PIQNRKQTIS GPPPSTTTTT TSTASNNVTS VGSPPNSGSV
LNSSGSKPVT FSSTSSPVQQ QTSALS
//
