ID   Q54LM1_DICDI            Unreviewed;       290 AA.
AC   Q54LM1;
DT   24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT   24-MAY-2005, sequence version 1.
DT   27-MAR-2024, entry version 104.
DE   RecName: Full=Short-chain dehydrogenase/reductase family protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=DDB_G0286575 {ECO:0000313|EMBL:EAL64043.1};
OS   Dictyostelium discoideum (Social amoeba).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL64043.1, ECO:0000313|Proteomes:UP000002195};
RN   [1] {ECO:0000313|EMBL:EAL64043.1, ECO:0000313|Proteomes:UP000002195}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4 {ECO:0000313|EMBL:EAL64043.1,
RC   ECO:0000313|Proteomes:UP000002195};
RX   PubMed=15875012; DOI=10.1038/nature03481;
RG   The Dictyostelium discoideum Sequencing Consortium;
RA   Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA   White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA   Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA   Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA   Noegel A.A., Barrell B., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000256|ARBA:ARBA00006484}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL64043.1}.
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DR   EMBL; AAFI02000089; EAL64043.1; -; Genomic_DNA.
DR   RefSeq; XP_637540.1; XM_632448.1.
DR   AlphaFoldDB; Q54LM1; -.
DR   SMR; Q54LM1; -.
DR   STRING; 44689.Q54LM1; -.
DR   PaxDb; 44689-DDB0187015; -.
DR   GeneID; 8625679; -.
DR   KEGG; ddi:DDB_G0286575; -.
DR   dictyBase; DDB_G0286575; -.
DR   eggNOG; KOG1208; Eukaryota.
DR   HOGENOM; CLU_010194_44_0_1; -.
DR   InParanoid; Q54LM1; -.
DR   OMA; HVQIPLL; -.
DR   PhylomeDB; Q54LM1; -.
DR   Reactome; R-DDI-5365859; RA biosynthesis pathway.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   PANTHER; PTHR24320:SF148; NAZGUL, ISOFORM A; 1.
DR   PANTHER; PTHR24320; RETINOL DEHYDROGENASE; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002195}.
SQ   SEQUENCE   290 AA;  32647 MW;  F8E5604C9535CD05 CRC64;
     MNKKVIILTG GTDGIGRNSL NYLINEDNLK LILPIRNLEK GEKVIQELKL INSNIDITTM
     EMDLSSFESI KSFVNEFNKL GLPLHTLVNN AGIMSPIYKK TVNGFESTFG TNYLGTFLLT
     NLLLPNLKKS NTESDKGNIV IVTSRMHYYV STLDIDNLEN INESNFSSGN EYNKSKVCDL
     LFAFELNNRL KSDGYDKIIN VNSIHPGFQI TSLSKDHGWF SNYIVLPILT FFLGNNINDM
     GKALAEISLN KSNVNGKYFQ LTTESQPSKL VTNNEISKSL WEKTIKLLEL
//