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Database: UniProt
Entry: Q54NJ4
LinkDB: Q54NJ4
Original site: Q54NJ4 
ID   DHX15_DICDI             Reviewed;         727 AA.
AC   Q54NJ4;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   29-OCT-2014, entry version 78.
DE   RecName: Full=Putative pre-mRNA-splicing factor ATP-dependent RNA helicase dhx15;
DE            EC=3.6.4.13;
DE   AltName: Full=DEAH box protein 15;
GN   Name=dhx15; Synonyms=prp43; ORFNames=DDB_G0285213;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A.,
RA   Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q.,
RA   Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F.,
RA   Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P.,
RA   Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P.,
RA   Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N.,
RA   Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M.,
RA   Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I.,
RA   Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R.,
RA   Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C.,
RA   Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D.,
RA   Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S.,
RA   Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T.,
RA   Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A.,
RA   Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M.,
RA   Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G.,
RA   Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Pre-mRNA processing factor involved in disassembly of
CC       spliceosomes after the release of mature mRNA. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH
CC       subfamily. DDX15/PRP43 sub-subfamily. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 1 helicase ATP-binding domain.
CC       {ECO:0000255|PROSITE-ProRule:PRU00541}.
CC   -!- SIMILARITY: Contains 1 helicase C-terminal domain.
CC       {ECO:0000255|PROSITE-ProRule:PRU00542}.
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DR   EMBL; AAFI02000076; EAL64818.1; -; Genomic_DNA.
DR   RefSeq; XP_638323.1; XM_633231.1.
DR   ProteinModelPortal; Q54NJ4; -.
DR   STRING; 44689.DDBDRAFT_0186395; -.
DR   EnsemblProtists; DDB0233403; DDB0233403; DDB_G0285213.
DR   GeneID; 8624993; -.
DR   KEGG; ddi:DDB_G0285213; -.
DR   dictyBase; DDB_G0285213; dhx15.
DR   eggNOG; COG1643; -.
DR   InParanoid; Q54NJ4; -.
DR   KO; K12820; -.
DR   OMA; FTSKDYY; -.
DR   PhylomeDB; Q54NJ4; -.
DR   PRO; PR:Q54NJ4; -.
DR   GO; GO:0005681; C:spliceosomal complex; ISS:dictyBase.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004004; F:ATP-dependent RNA helicase activity; ISS:dictyBase.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006200; P:ATP catabolic process; ISS:GOC.
DR   GO; GO:0006397; P:mRNA processing; ISS:dictyBase.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR011709; DUF1605.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF04408; HA2; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase; mRNA processing;
KW   mRNA splicing; Nucleotide-binding; Nucleus; Reference proteome.
FT   CHAIN         1    727       Putative pre-mRNA-splicing factor ATP-
FT                                dependent RNA helicase dhx15.
FT                                /FTId=PRO_0000330940.
FT   DOMAIN       87    251       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      273    445       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     100    107       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF       198    201       DEAH box.
FT   COMPBIAS     24     29       Poly-Glu.
FT   COMPBIAS     31     40       Poly-Thr.
SQ   SEQUENCE   727 AA;  82858 MW;  153EA093D51E89FB CRC64;
     MSKRKHESSD SNKKAMKKQQ NKIEEEEEEI TNTTTTTTTT NNNYNNIKSN LTIDQWIPKK
     ETFSKRYYEI LEKRKELPVW KQKEDFIKVI KENQVVILVG ETGSGKTTQI PQFVVDAGLI
     RPGKMVGVTQ PRRVAAISVA KRVSEEMDFE LGEEVGYSIR FEELSSARTF MKYLTDGMLL
     RESMSDPTLN KYDVIILDEA HERTLSTDIL FGLIKDILKR RKDLKLIVMS ATLEAGKFQK
     YFENAPLIKV PGRLHPVEIF YTEEAAKDYL ESAVRTVIDI HTNEGTGDIL VFLTGEEEIE
     DTCAKIQRET RERGLPPMKT LPLYSSLPIY QQSKIFDTCK ERKCIVSTNI AETSLTIDGI
     VFVVDPGFSK QKTYNPRSRV ESLLVAPISK ASANQRAGRA GRTRPGKCFR LYTEKAFKEL
     MIQQTHPEIL RSNLASVVLQ LLKLGVVDLV HFDFMDPPVP DTLIRALEVL HYLGALDDEG
     QLTEIGSIMS EFPLDPQLSK MLIVSAERSC SNEILTIAAM LSAPNCFMRP KDNRIEADSA
     KKSFDHFDGD HLTMLNVYHS FKKNGEDPTW CYDNFLNHRA IKQADSVRSQ LARILTRFKL
     PLVSGDVNSK FYYENIKKCI AAGFFMQVAK CEKKNIYFTL GDEQSVIFHP STGLTRRPEF
     CIYNEFVLTS ENYIRTITDV KFDWLLELAP SYFKQKSFPK KTKETIQRAQ RLYSGSSSGS
     SSGSNKK
//
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