ID GEFP_DICDI Reviewed; 1502 AA.
AC Q54TK8; Q8IS10;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 29-MAY-2013, entry version 48.
DE RecName: Full=Ras guanine nucleotide exchange factor P;
DE AltName: Full=RasGEF domain-containing protein P;
GN Name=gefP; Synonyms=rasGEFP; ORFNames=DDB_G0281573;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DEVELOPMENTAL STAGE.
RC STRAIN=AX4;
RX PubMed=16086850; DOI=10.1186/gb-2005-6-8-r68;
RA Wilkins A., Szafranski K., Fraser D.J., Bakthavatsalam D., Mueller R.,
RA Fisher P.R., Gloeckner G., Eichinger L., Noegel A.A., Insall R.H.;
RT "The Dictyostelium genome encodes numerous RasGEFs with multiple
RT biological roles.";
RL Genome Biol. 6:R68.1-R68.12(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A.,
RA Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q.,
RA Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F.,
RA Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P.,
RA Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P.,
RA Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N.,
RA Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M.,
RA Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I.,
RA Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R.,
RA Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C.,
RA Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D.,
RA Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S.,
RA Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T.,
RA Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A.,
RA Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M.,
RA Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G.,
RA Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Promotes the exchange of Ras-bound GDP by GTP (By
CC similarity).
CC -!- DEVELOPMENTAL STAGE: Faintly expressed during development.
CC -!- SIMILARITY: Contains 1 CH (calponin-homology) domain.
CC -!- SIMILARITY: Contains 1 N-terminal Ras-GEF domain.
CC -!- SIMILARITY: Contains 1 Ras-GEF domain.
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DR EMBL; AY160105; AAN46885.1; -; Genomic_DNA.
DR EMBL; AAFI02000042; EAL66548.1; -; Genomic_DNA.
DR RefSeq; XP_640583.1; XM_635491.1.
DR ProteinModelPortal; Q54TK8; -.
DR EnsemblProtists; DDB0215009; DDB0215009; DDB_G0281573.
DR GeneID; 8623191; -.
DR KEGG; ddi:DDB_G0281573; -.
DR dictyBase; DDB_G0281573; gefP.
DR eggNOG; NOG265981; -.
DR InParanoid; Q54TK8; -.
DR OMA; ICEPRES; -.
DR ProtClustDB; CLSZ2846782; -.
DR GO; GO:0005622; C:intracellular; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 1.10.418.10; -; 1.
DR Gene3D; 1.10.840.10; -; 1.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR008937; Ras_GEF.
DR InterPro; IPR023578; Ras_GEF_dom.
DR InterPro; IPR001895; RasGRF_CDC25.
DR PANTHER; PTHR23113; PTHR23113; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF47576; Calponin-homology; 1.
DR SUPFAM; SSF48366; Ras_GEF; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS00720; RASGEF; FALSE_NEG.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Complete proteome; Guanine-nucleotide releasing factor;
KW Reference proteome.
FT CHAIN 1 1502 Ras guanine nucleotide exchange factor P.
FT /FTId=PRO_0000384474.
FT DOMAIN 84 187 CH.
FT DOMAIN 1102 1249 N-terminal Ras-GEF.
FT DOMAIN 1267 1498 Ras-GEF.
FT COILED 287 328 Potential.
FT COILED 451 515 Potential.
FT COILED 1032 1076 Potential.
FT COMPBIAS 218 222 Poly-Ser.
FT COMPBIAS 253 257 Poly-Ser.
FT COMPBIAS 287 328 Poly-Gln.
FT COMPBIAS 342 346 Poly-Thr.
FT COMPBIAS 353 356 Poly-Pro.
FT COMPBIAS 402 405 Poly-Pro.
FT COMPBIAS 406 409 Poly-Ser.
FT COMPBIAS 458 510 Poly-Asn.
FT COMPBIAS 587 591 Poly-Thr.
FT COMPBIAS 615 646 Poly-Asn.
FT COMPBIAS 690 706 Poly-Asn.
FT COMPBIAS 802 805 Poly-Lys.
FT COMPBIAS 813 853 Poly-Asn.
FT COMPBIAS 891 913 Gln-rich.
FT COMPBIAS 1075 1080 Poly-Gln.
FT CONFLICT 109 109 S -> P (in Ref. 1; AAN46885).
FT CONFLICT 185 185 F -> C (in Ref. 1; AAN46885).
SQ SEQUENCE 1502 AA; 168949 MW; ABFBC89FDE90845C CRC64;
MNDSTQILDE SGDFSFLSLN ENKSRSRSTS TCSINSVEII DGGSCDSSGD DDKNNSYLDE
EKKRILRKTY LYFNANNKKT QLNFIIDNQV LDWIFNQTKT KISKPICESL KNGVALCKII
NLIKPNTIKK INLNSSIFSY RENLTNFTKG CESIGMTEDM SRFQELVFED KESAVLQLLY
SLMKFSEKIL PNTISTSPPS QLNICKSPVL LKKAAAQSSS SSPTTSTSAS TSTSTSPSSS
NESIAKPILS ALSSSSSTLF SAAPTPTSTN TVPYKFIGHS KSKLFGQQQQ QQQQQQQQQQ
QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQPP PQTSTCTTTQ PTTTTTEEHK LAPPPPLIVP
NTSSLPPPQP TTSSIIKKAA PAPLKKPSPA NTSSNSLLNH LPPPPSSSST ASSAINTPIS
TPSTSKSNSF QKPNNNFQKP IQIAHVEPII EENEIEDNTN NNNNNNNNNN NNNNNNNNNN
NNNNNNNNNN NTNDNINNNN KNNNNNQNEN EDEVKPVHSP PKVRPPLPSR VGRGQLLRSS
SEEIQFDIEN ASVSEAPSPV MTMNEDYSIV TDANSLTNHY NGANEYTTTT TAATTNLPNE
SSSRSNSASS NGDQNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNLQLP AKINSEPNNQ
YNTISTSSPS TTGTILESPN GSSIFSQPLN NNNNINNENN NSNNSNSLVT SSSPPLSLPA
YSANGSPNCP QGKKQRSGTK LRSFFGVKSK PESKSVSNFY GVGNSINQPP SNSSPKQSPV
PNNPPSVSQS FLNLSMNSKS SKKKKDNISP DINSNSNNNN NNNNNNNNNN NNNNNNNNNN
NNNNNNNNNN NNNLEEDENP LTMSNQSANS LKSSGNHFED DITNGNNNIS QNQNQNQNQN
QNQTQNQNQN QNQNHISHSN SISSGNLNNH VNQNNNVNEE SVDSELMKAL SKVEFLFKDR
KVLKERINFT YPEKYLKFFV NMDELIQIDN STTFLTESLL SKRPSQQLEL CHQEERRFLS
EIVTLQNVLN VVEENKNLIT RTEEMQKMID SLMKEKKELI NEKNTLASML AKTKQQQQQQ
SNDTVSQRKM VDDGIVYNYN HGKYEIKGGT TEKLIELLYN SEFIGSDYFE TFLLTYRSFA
SPKRVMDVLT KTYNENYSVE GNATDDVEKR LELDQFNKQR KDTHLKICNF LKRWVEKHFY
DFDQDLLQEF NTFIANCRVI NHQDFLQKTL NKKLIPLSSS ELKLVFSTPT PAPILPKTPI
TCFEDMDPAE IARQLTLIEF NLFKNIANKE FLSLSWQKQD KEKRSPNLLK MIYRFNEVSN
WVTSTIVKET TNIKKRASYL KRFIKLAEEL RKLNNFNGVF VIVSGLHSAS VNRLKNTWAE
ISKQQQKQFE EFVALTSPQS SFASYRLELR QSTGASIPYL GVHLSDLTFV EEGNQDKLEN
GYTNFSKCRL IAEQIKAIQE FQQEPYNLRE VEEMIPFITH KAVPESECFN LSLICEPRES
VN
//
