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Database: UniProt
Entry: Q54TK8
LinkDB: Q54TK8
Original site: Q54TK8 
ID   GEFP_DICDI              Reviewed;        1502 AA.
AC   Q54TK8; Q8IS10;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   01-OCT-2014, entry version 55.
DE   RecName: Full=Ras guanine nucleotide exchange factor P;
DE   AltName: Full=RasGEF domain-containing protein P;
GN   Name=gefP; Synonyms=rasGEFP; ORFNames=DDB_G0281573;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DEVELOPMENTAL STAGE.
RC   STRAIN=AX4;
RX   PubMed=16086850; DOI=10.1186/gb-2005-6-8-r68;
RA   Wilkins A., Szafranski K., Fraser D.J., Bakthavatsalam D., Mueller R.,
RA   Fisher P.R., Gloeckner G., Eichinger L., Noegel A.A., Insall R.H.;
RT   "The Dictyostelium genome encodes numerous RasGEFs with multiple
RT   biological roles.";
RL   Genome Biol. 6:R68.1-R68.12(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A.,
RA   Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q.,
RA   Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F.,
RA   Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P.,
RA   Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P.,
RA   Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N.,
RA   Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M.,
RA   Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I.,
RA   Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R.,
RA   Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C.,
RA   Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D.,
RA   Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S.,
RA   Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T.,
RA   Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A.,
RA   Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M.,
RA   Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G.,
RA   Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Promotes the exchange of Ras-bound GDP by GTP.
CC       {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Faintly expressed during development.
CC       {ECO:0000269|PubMed:16086850}.
CC   -!- SIMILARITY: Contains 1 CH (calponin-homology) domain.
CC       {ECO:0000255|PROSITE-ProRule:PRU00044}.
CC   -!- SIMILARITY: Contains 1 N-terminal Ras-GEF domain.
CC       {ECO:0000255|PROSITE-ProRule:PRU00135}.
CC   -!- SIMILARITY: Contains 1 Ras-GEF domain. {ECO:0000255|PROSITE-
CC       ProRule:PRU00168}.
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DR   EMBL; AY160105; AAN46885.1; -; Genomic_DNA.
DR   EMBL; AAFI02000042; EAL66548.1; -; Genomic_DNA.
DR   RefSeq; XP_640583.1; XM_635491.1.
DR   ProteinModelPortal; Q54TK8; -.
DR   EnsemblProtists; DDB0215009; DDB0215009; DDB_G0281573.
DR   GeneID; 8623191; -.
DR   KEGG; ddi:DDB_G0281573; -.
DR   dictyBase; DDB_G0281573; gefP.
DR   eggNOG; NOG265981; -.
DR   InParanoid; Q54TK8; -.
DR   OMA; ICEPRES; -.
DR   Reactome; REACT_204273; Rho GTPase cycle.
DR   Reactome; REACT_211603; NRAGE signals death through JNK.
DR   GO; GO:0005622; C:intracellular; IEA:InterPro.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.418.10; -; 1.
DR   Gene3D; 1.10.840.10; -; 1.
DR   InterPro; IPR001715; CH-domain.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR023578; Ras_GEF_dom.
DR   InterPro; IPR001895; RasGRF_CDC25.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00033; CH; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF47576; SSF47576; 1.
DR   SUPFAM; SSF48366; SSF48366; 1.
DR   PROSITE; PS50021; CH; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Complete proteome; Guanine-nucleotide releasing factor;
KW   Reference proteome.
FT   CHAIN         1   1502       Ras guanine nucleotide exchange factor P.
FT                                /FTId=PRO_0000384474.
FT   DOMAIN       84    187       CH. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00044}.
FT   DOMAIN     1102   1249       N-terminal Ras-GEF. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00135}.
FT   DOMAIN     1267   1498       Ras-GEF. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00168}.
FT   COILED      287    328       {ECO:0000255}.
FT   COILED      451    515       {ECO:0000255}.
FT   COILED     1032   1076       {ECO:0000255}.
FT   COMPBIAS    218    222       Poly-Ser.
FT   COMPBIAS    253    257       Poly-Ser.
FT   COMPBIAS    287    328       Poly-Gln.
FT   COMPBIAS    342    346       Poly-Thr.
FT   COMPBIAS    353    356       Poly-Pro.
FT   COMPBIAS    402    405       Poly-Pro.
FT   COMPBIAS    406    409       Poly-Ser.
FT   COMPBIAS    458    510       Poly-Asn.
FT   COMPBIAS    587    591       Poly-Thr.
FT   COMPBIAS    615    646       Poly-Asn.
FT   COMPBIAS    690    706       Poly-Asn.
FT   COMPBIAS    802    805       Poly-Lys.
FT   COMPBIAS    813    853       Poly-Asn.
FT   COMPBIAS    891    913       Gln-rich.
FT   COMPBIAS   1075   1080       Poly-Gln.
FT   CONFLICT    109    109       S -> P (in Ref. 1; AAN46885).
FT                                {ECO:0000305}.
FT   CONFLICT    185    185       F -> C (in Ref. 1; AAN46885).
FT                                {ECO:0000305}.
SQ   SEQUENCE   1502 AA;  168949 MW;  ABFBC89FDE90845C CRC64;
     MNDSTQILDE SGDFSFLSLN ENKSRSRSTS TCSINSVEII DGGSCDSSGD DDKNNSYLDE
     EKKRILRKTY LYFNANNKKT QLNFIIDNQV LDWIFNQTKT KISKPICESL KNGVALCKII
     NLIKPNTIKK INLNSSIFSY RENLTNFTKG CESIGMTEDM SRFQELVFED KESAVLQLLY
     SLMKFSEKIL PNTISTSPPS QLNICKSPVL LKKAAAQSSS SSPTTSTSAS TSTSTSPSSS
     NESIAKPILS ALSSSSSTLF SAAPTPTSTN TVPYKFIGHS KSKLFGQQQQ QQQQQQQQQQ
     QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQPP PQTSTCTTTQ PTTTTTEEHK LAPPPPLIVP
     NTSSLPPPQP TTSSIIKKAA PAPLKKPSPA NTSSNSLLNH LPPPPSSSST ASSAINTPIS
     TPSTSKSNSF QKPNNNFQKP IQIAHVEPII EENEIEDNTN NNNNNNNNNN NNNNNNNNNN
     NNNNNNNNNN NTNDNINNNN KNNNNNQNEN EDEVKPVHSP PKVRPPLPSR VGRGQLLRSS
     SEEIQFDIEN ASVSEAPSPV MTMNEDYSIV TDANSLTNHY NGANEYTTTT TAATTNLPNE
     SSSRSNSASS NGDQNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNLQLP AKINSEPNNQ
     YNTISTSSPS TTGTILESPN GSSIFSQPLN NNNNINNENN NSNNSNSLVT SSSPPLSLPA
     YSANGSPNCP QGKKQRSGTK LRSFFGVKSK PESKSVSNFY GVGNSINQPP SNSSPKQSPV
     PNNPPSVSQS FLNLSMNSKS SKKKKDNISP DINSNSNNNN NNNNNNNNNN NNNNNNNNNN
     NNNNNNNNNN NNNLEEDENP LTMSNQSANS LKSSGNHFED DITNGNNNIS QNQNQNQNQN
     QNQTQNQNQN QNQNHISHSN SISSGNLNNH VNQNNNVNEE SVDSELMKAL SKVEFLFKDR
     KVLKERINFT YPEKYLKFFV NMDELIQIDN STTFLTESLL SKRPSQQLEL CHQEERRFLS
     EIVTLQNVLN VVEENKNLIT RTEEMQKMID SLMKEKKELI NEKNTLASML AKTKQQQQQQ
     SNDTVSQRKM VDDGIVYNYN HGKYEIKGGT TEKLIELLYN SEFIGSDYFE TFLLTYRSFA
     SPKRVMDVLT KTYNENYSVE GNATDDVEKR LELDQFNKQR KDTHLKICNF LKRWVEKHFY
     DFDQDLLQEF NTFIANCRVI NHQDFLQKTL NKKLIPLSSS ELKLVFSTPT PAPILPKTPI
     TCFEDMDPAE IARQLTLIEF NLFKNIANKE FLSLSWQKQD KEKRSPNLLK MIYRFNEVSN
     WVTSTIVKET TNIKKRASYL KRFIKLAEEL RKLNNFNGVF VIVSGLHSAS VNRLKNTWAE
     ISKQQQKQFE EFVALTSPQS SFASYRLELR QSTGASIPYL GVHLSDLTFV EEGNQDKLEN
     GYTNFSKCRL IAEQIKAIQE FQQEPYNLRE VEEMIPFITH KAVPESECFN LSLICEPRES
     VN
//
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