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Database: UniProt
Entry: Q54U71
LinkDB: Q54U71
Original site: Q54U71 
ID   COQ2_DICDI              Reviewed;         463 AA.
AC   Q54U71;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   09-JUL-2014, entry version 55.
DE   RecName: Full=4-hydroxybenzoate polyprenyltransferase, mitochondrial;
DE            EC=2.5.1.39;
DE   AltName: Full=Para-hydroxybenzoate--polyprenyltransferase;
DE            Short=PHB:polyprenyltransferase;
DE   Flags: Precursor;
GN   Name=coq2; ORFNames=DDB_G0281241;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A.,
RA   Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q.,
RA   Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F.,
RA   Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P.,
RA   Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P.,
RA   Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N.,
RA   Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M.,
RA   Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I.,
RA   Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R.,
RA   Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C.,
RA   Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D.,
RA   Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S.,
RA   Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T.,
RA   Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A.,
RA   Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M.,
RA   Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G.,
RA   Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Catalyzes the prenylation of para-hydroxybenzoate (PHB)
CC       with an all-trans polyprenyl group. Mediates the second step in
CC       the final reaction sequence of coenzyme Q (CoQ) biosynthesis,
CC       which is the condensation of the polyisoprenoid side chain with
CC       PHB.
CC   -!- CATALYTIC ACTIVITY: A polyprenyl diphosphate + 4-hydroxybenzoate =
CC       diphosphate + a 4-hydroxy-3-polyprenylbenzoate.
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane; Multi-pass membrane
CC       protein (By similarity).
CC   -!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
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DR   EMBL; AAFI02000040; EAL66917.1; -; Genomic_DNA.
DR   RefSeq; XP_640905.1; XM_635813.1.
DR   STRING; 44689.DDB_0231591; -.
DR   EnsemblProtists; DDB0231591; DDB0231591; DDB_G0281241.
DR   GeneID; 8622964; -.
DR   KEGG; ddi:DDB_G0281241; -.
DR   dictyBase; DDB_G0281241; coq2.
DR   eggNOG; COG0382; -.
DR   OMA; VINDMAD; -.
DR   PhylomeDB; Q54U71; -.
DR   UniPathway; UPA00232; -.
DR   PRO; PR:Q54U71; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; ISS:dictyBase.
DR   GO; GO:0002083; F:4-hydroxybenzoate decaprenyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0047293; F:4-hydroxybenzoate nonaprenyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008412; F:4-hydroxybenzoate octaprenyltransferase activity; ISS:dictyBase.
DR   GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; ISS:dictyBase.
DR   InterPro; IPR006370; HB_polyprenyl-transferase.
DR   InterPro; IPR000537; UbiA_prenyltransferase.
DR   Pfam; PF01040; UbiA; 1.
DR   TIGRFAMs; TIGR01474; ubiA_proteo; 1.
DR   PROSITE; PS00943; UBIA; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Isoprene biosynthesis; Membrane; Mitochondrion;
KW   Reference proteome; Transferase; Transit peptide; Transmembrane;
KW   Transmembrane helix; Ubiquinone biosynthesis.
FT   TRANSIT       1     20       Mitochondrion (Potential).
FT   CHAIN        21    463       4-hydroxybenzoate polyprenyltransferase,
FT                                mitochondrial.
FT                                /FTId=PRO_0000328211.
FT   TRANSMEM    181    201       Helical; (Potential).
FT   TRANSMEM    206    226       Helical; (Potential).
FT   TRANSMEM    257    277       Helical; (Potential).
FT   TRANSMEM    305    325       Helical; (Potential).
FT   TRANSMEM    330    350       Helical; (Potential).
FT   TRANSMEM    375    395       Helical; (Potential).
FT   TRANSMEM    431    451       Helical; (Potential).
FT   COMPBIAS     26     38       Poly-Asn.
FT   COMPBIAS     48     53       Poly-Asn.
FT   COMPBIAS     94     97       Poly-Asn.
FT   COMPBIAS    137    150       Poly-Asn.
SQ   SEQUENCE   463 AA;  51925 MW;  00E676D1035B59F3 CRC64;
     MIKSILSLQN FKFIKPCTNS SILKYNNNNN TNNNNNNNGI NKYNSTFNNN NSNFSNKNLF
     SSKQYQQQSI CNIPILSTIS YHNKNNTNIN TIINNNNSSN NNLINLNDKF NNLNNKTSPI
     IFNKNYSTTV STLLDDNNSN SNNNNNSNNN KPSTTFVNDW ISKFPNSVQP YLRLSRVDKP
     IGVWLLLYPC CWSISLAAPA GSFPDLKTML VFGIGAYVMR SAGCVINDMA DYKFDSKVER
     TKTRPIASKQ LTHKQSLIFL GGQLLASFGL ILSSLNYYTI ALCASSLPIV VLYPFMKRFT
     YYPQFVLGLA FNWGALAGYS AIAGSCNWSI VAPLYLAGIS WTMVYDTIYA HQDKRDDILV
     GVKSTALKFA EKSRIILSVF SGLVISGMFL TGIAANMPLF YYLGTAACSS HLIWQLKTVD
     FNNPSSCLEK FISNKNFGLY FLLIIIVSKL LQDKENENEI QKK
//
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