ID Q54WF2_DICDI Unreviewed; 1164 AA.
AC Q54WF2;
DT 24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 24-MAY-2005, sequence version 1.
DT 24-JAN-2024, entry version 131.
DE SubName: Full=Elongation factor Tu domain-containing protein {ECO:0000313|EMBL:EAL67619.1};
GN Name=eftud1 {ECO:0000313|EMBL:EAL67619.1};
GN ORFNames=DDB_G0279689 {ECO:0000313|EMBL:EAL67619.1};
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL67619.1, ECO:0000313|Proteomes:UP000002195};
RN [1] {ECO:0000313|EMBL:EAL67619.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL67619.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=15875012; DOI=10.1038/nature03481;
RG The Dictyostelium discoideum Sequencing Consortium;
RA Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA Noegel A.A., Barrell B., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL67619.1}.
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DR EMBL; AAFI02000032; EAL67619.1; -; Genomic_DNA.
DR RefSeq; XP_641601.1; XM_636509.1.
DR AlphaFoldDB; Q54WF2; -.
DR SMR; Q54WF2; -.
DR STRING; 44689.Q54WF2; -.
DR PaxDb; 44689-DDB0235191; -.
DR GeneID; 8622177; -.
DR KEGG; ddi:DDB_G0279689; -.
DR dictyBase; DDB_G0279689; eftud1.
DR eggNOG; KOG0467; Eukaryota.
DR HOGENOM; CLU_002794_3_1_1; -.
DR InParanoid; Q54WF2; -.
DR OMA; FARCDIQ; -.
DR PhylomeDB; Q54WF2; -.
DR PRO; PR:Q54WF2; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005737; C:cytoplasm; IDA:dictyBase.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0042256; P:cytosolic ribosome assembly; IBA:GO_Central.
DR CDD; cd01681; aeEF2_snRNP_like_IV; 1.
DR CDD; cd04096; eEF2_snRNP_like_C; 1.
DR CDD; cd01885; EF2; 1.
DR CDD; cd16261; EF2_snRNP_III; 1.
DR Gene3D; 3.30.230.10; -; 2.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR041095; EFG_II.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR42908:SF3; ELONGATION FACTOR-LIKE GTPASE 1; 1.
DR PANTHER; PTHR42908; TRANSLATION ELONGATION FACTOR-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF14492; EFG_III; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SMART; SM00838; EFG_C; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 2.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Elongation factor {ECO:0000313|EMBL:EAL67619.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000313|EMBL:EAL67619.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002195}.
FT DOMAIN 17..368
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 380..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 443..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 485..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 717..747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 806..829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 877..933
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..400
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 893..925
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1164 AA; 130130 MW; D2C3E7453CDA4857 CRC64;
MPSISPNLLA SLQDHTKNIR NICVLAHVDH GKTTLSDCLI SSNGIISPEM AGKLRYLDFL
EDEQEREITM KASAISLLFQ QPSSSSSSND KESFLINLID SPGHVDFSSE VSTAVRITDG
ALVLVDAVEG VCIQTHAVLK QAYQEKVKPC LVLNKIDRLI LELHMTPLEA YQHLSKIIEQ
VNVITGTLTS EEIILKESSE DYIESSDDSN LNFNENIGTE YYFSPQKGNV AFTTAFDGWG
FTIKQFIDLC YKKTGIKKEI LEKCLWGEYY YHPKEKKIYK SPKGNLMPMF VTFILNSVWE
VVKTIVGTPE WIDRDRLDKM ISVLNITVGA RDLASKDQKI VLKSVLHAWL PLSEAVLSMV
CDKLPDPIEG QARRMEKIFK PSKSLSTSSS SSSSSSNQSN VELIEKQKQL LYDTITCNSS
DDCEIVAYVA KVFAHNKRGG VQTSTIHRPV PPRRVQPSAV PSQNRQQQLH QDEKDILKID
NMFISSAPST TNDSTTTTKT TTTSPSSPIT STAKPLDLST IPTGPIKANN NDEEFIAVVR
VFSGVLKKGK TIYVMGPRYD PMNPTHDVYK VEITHLYLLM GSSLEPIDKV PAGNVCGVGG
GVGNLVLKSA TISSSLMCPP ISNMMFVSSP IVKVALEPEN ISDLPKLLHG LKLLNQADPL
VEVYVQETGE HVIVASGELH LERCIRDLKE SFAKINVHVS SPIVPFRETI ITPTITTPTT
SSTITSSSST TAAATATTTN NSGQQSPPLK EIITVKTANK KVSVKIRAIP LPKNITNLIE
QRSQQLRDLF LGGKNTNKEL SDNKITKREA EQAEREDFQK ELEEELEKSG GDWKNEIKNI
WSFGPRHIGP NLLLNHIPGY NLSPYWKHSL QRGIQKKLKK LQKQQQQEKE EIKEEEEEKE
EEEKEDEEDE DEKEIEEEEI QEEENSNSEV GSIKLLDGDD KFKRISELDN SIVSGFQLAT
IAGPLCDEPM MGVCLIVEDI DIIREEGDQQ NSDSYGPLSG QMISTVKEGC RMAFQIKPQR
LMEALYLCEI QVTSTALGKM YSVLSSRRAQ IQKEGVKEGT QIFCIQARLP VVESFGFSQQ
IMIKTSGAAS TQLFFDNYWE TIEQDPYYEP TTEEELEDNG VNIASLGNNI ARQYMNMIRK
RKGLFVEEKL VEHADKQRTL KKNK
//
