ID Q54WT3_DICDI Unreviewed; 864 AA.
AC Q54WT3;
DT 24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 24-MAY-2005, sequence version 1.
DT 24-JAN-2024, entry version 96.
DE RecName: Full=Peptidase A1 domain-containing protein {ECO:0000259|PROSITE:PS51767};
GN ORFNames=DDB_G0279453 {ECO:0000313|EMBL:EAL67665.1};
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL67665.1, ECO:0000313|Proteomes:UP000002195};
RN [1] {ECO:0000313|EMBL:EAL67665.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL67665.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=15875012; DOI=10.1038/nature03481;
RG The Dictyostelium discoideum Sequencing Consortium;
RA Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA Noegel A.A., Barrell B., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL67665.1}.
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DR EMBL; AAFI02000031; EAL67665.1; -; Genomic_DNA.
DR RefSeq; XP_641634.1; XM_636542.1.
DR AlphaFoldDB; Q54WT3; -.
DR SMR; Q54WT3; -.
DR STRING; 44689.Q54WT3; -.
DR MEROPS; A01.A88; -.
DR PaxDb; 44689-DDB0205773; -.
DR GeneID; 8622040; -.
DR KEGG; ddi:DDB_G0279453; -.
DR dictyBase; DDB_G0279453; -.
DR eggNOG; KOG1339; Eukaryota.
DR HOGENOM; CLU_331635_0_0_1; -.
DR InParanoid; Q54WT3; -.
DR OMA; FWEGNCH; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd05471; pepsin_like; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR034164; Pepsin-like_dom.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR13683; ASPARTYL PROTEASES; 1.
DR PANTHER; PTHR13683:SF375; PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR601461-2};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002195};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..864
FT /note="Peptidase A1 domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004249937"
FT TRANSMEM 683..707
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 165..522
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT REGION 76..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 746..831
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..779
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 787..825
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 183
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 402
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT DISULFID 196..210
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 864 AA; 96245 MW; BA7A6F6F2C19DAE5 CRC64;
MKIIVVLFLI CSLFPHSTLS NSIEIIRRNK HINLYHPETN ELIISSPINN KIFSHQHIHT
LINKNYNNKN EYLNIQNNNN NNNNNNLINN SKLQINDNNN SSSSGSGSSS NSSSNSNNNN
NKKKIYNHLK LKSDYDYKNN NSYLFKESIS SSSILYGGIT SSFEYFIPIL VGTPPQMFTV
QVDTGSTSLA VPGLNCYLYK SQTIKTSCSC SDGNLDGLYN FDDSVSGIAL NCSASVCNNS
CQNKNHDNCP FMLKYGDGSF IAGSLVIDNV TIGQFTVPAK FGNIQKESLS FSQLTCPSNA
RSQAVRDGIL GLSFQELDPY NGDDIFSKIV SSYGIPNVFS MCLGKDGGIL TIGGINERVN
IETPKYTPII DFHYYSIHVL NIYVENESLK FTPNDFISSI VDSGTTLLYF NDEIFYSIIK
NLEQSYSKLP GIGEDKFWEG NCHYLSEESV ELYPTIYLEL DGSGASGSFK LAIPPSLYFL
KINNLHCFGI SHMKEISVLI GDVVLQGYNV IYDRGNSRIG FAKIENCKTS NSDNSPLKLS
IVNGNFQKAT EENQFRHPLV LSLKTNKNAT LSINGNSTNY NNKNNNRLNK TKEIYGNNND
DDSVNDDDEP IGGVIIGFSI TSGNAYFYPS YMTSIRNITD ADGLVSVLVV PRFFGKISVE
AMVWGNNNTN IVSFTLHSNM KPWKIIIISL SVFGCSILIL LICFFFYKKK TLRSSNNNNS
NNNKRNNKTN INDLEVNIDN EGVESLLNNE NSSNNNNNNN NNNNKNNNNK NNNNVGDLEN
NIDNEDEGLL KNQNSTINNN KNNNNNDSSC ISSSSSNFKN NNDKNNENLK SGKEWDLFSD
SLIKSLNSDF NISSLGKNFN DITE
//