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Database: UniProt
Entry: Q54WT3_DICDI
LinkDB: Q54WT3_DICDI
Original site: Q54WT3_DICDI 
ID   Q54WT3_DICDI            Unreviewed;       864 AA.
AC   Q54WT3;
DT   24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT   24-MAY-2005, sequence version 1.
DT   24-JAN-2024, entry version 96.
DE   RecName: Full=Peptidase A1 domain-containing protein {ECO:0000259|PROSITE:PS51767};
GN   ORFNames=DDB_G0279453 {ECO:0000313|EMBL:EAL67665.1};
OS   Dictyostelium discoideum (Social amoeba).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL67665.1, ECO:0000313|Proteomes:UP000002195};
RN   [1] {ECO:0000313|EMBL:EAL67665.1, ECO:0000313|Proteomes:UP000002195}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4 {ECO:0000313|EMBL:EAL67665.1,
RC   ECO:0000313|Proteomes:UP000002195};
RX   PubMed=15875012; DOI=10.1038/nature03481;
RG   The Dictyostelium discoideum Sequencing Consortium;
RA   Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA   White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA   Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA   Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA   Noegel A.A., Barrell B., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC       {ECO:0000256|ARBA:ARBA00007447}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL67665.1}.
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DR   EMBL; AAFI02000031; EAL67665.1; -; Genomic_DNA.
DR   RefSeq; XP_641634.1; XM_636542.1.
DR   AlphaFoldDB; Q54WT3; -.
DR   SMR; Q54WT3; -.
DR   STRING; 44689.Q54WT3; -.
DR   MEROPS; A01.A88; -.
DR   PaxDb; 44689-DDB0205773; -.
DR   GeneID; 8622040; -.
DR   KEGG; ddi:DDB_G0279453; -.
DR   dictyBase; DDB_G0279453; -.
DR   eggNOG; KOG1339; Eukaryota.
DR   HOGENOM; CLU_331635_0_0_1; -.
DR   InParanoid; Q54WT3; -.
DR   OMA; FWEGNCH; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd05471; pepsin_like; 1.
DR   Gene3D; 2.40.70.10; Acid Proteases; 2.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR034164; Pepsin-like_dom.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   PANTHER; PTHR13683; ASPARTYL PROTEASES; 1.
DR   PANTHER; PTHR13683:SF375; PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00026; Asp; 1.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR601461-2};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002195};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..864
FT                   /note="Peptidase A1 domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004249937"
FT   TRANSMEM        683..707
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          165..522
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000259|PROSITE:PS51767"
FT   REGION          76..122
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          746..831
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        746..779
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        787..825
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        183
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   ACT_SITE        402
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   DISULFID        196..210
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ   SEQUENCE   864 AA;  96245 MW;  BA7A6F6F2C19DAE5 CRC64;
     MKIIVVLFLI CSLFPHSTLS NSIEIIRRNK HINLYHPETN ELIISSPINN KIFSHQHIHT
     LINKNYNNKN EYLNIQNNNN NNNNNNLINN SKLQINDNNN SSSSGSGSSS NSSSNSNNNN
     NKKKIYNHLK LKSDYDYKNN NSYLFKESIS SSSILYGGIT SSFEYFIPIL VGTPPQMFTV
     QVDTGSTSLA VPGLNCYLYK SQTIKTSCSC SDGNLDGLYN FDDSVSGIAL NCSASVCNNS
     CQNKNHDNCP FMLKYGDGSF IAGSLVIDNV TIGQFTVPAK FGNIQKESLS FSQLTCPSNA
     RSQAVRDGIL GLSFQELDPY NGDDIFSKIV SSYGIPNVFS MCLGKDGGIL TIGGINERVN
     IETPKYTPII DFHYYSIHVL NIYVENESLK FTPNDFISSI VDSGTTLLYF NDEIFYSIIK
     NLEQSYSKLP GIGEDKFWEG NCHYLSEESV ELYPTIYLEL DGSGASGSFK LAIPPSLYFL
     KINNLHCFGI SHMKEISVLI GDVVLQGYNV IYDRGNSRIG FAKIENCKTS NSDNSPLKLS
     IVNGNFQKAT EENQFRHPLV LSLKTNKNAT LSINGNSTNY NNKNNNRLNK TKEIYGNNND
     DDSVNDDDEP IGGVIIGFSI TSGNAYFYPS YMTSIRNITD ADGLVSVLVV PRFFGKISVE
     AMVWGNNNTN IVSFTLHSNM KPWKIIIISL SVFGCSILIL LICFFFYKKK TLRSSNNNNS
     NNNKRNNKTN INDLEVNIDN EGVESLLNNE NSSNNNNNNN NNNNKNNNNK NNNNVGDLEN
     NIDNEDEGLL KNQNSTINNN KNNNNNDSSC ISSSSSNFKN NNDKNNENLK SGKEWDLFSD
     SLIKSLNSDF NISSLGKNFN DITE
//
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