ID Q54ZK0_DICDI Unreviewed; 1113 AA.
AC Q54ZK0;
DT 24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 24-MAY-2005, sequence version 1.
DT 24-JAN-2024, entry version 105.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
GN ORFNames=DDB_G0277555 {ECO:0000313|EMBL:EAL68740.1};
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL68740.1, ECO:0000313|Proteomes:UP000002195};
RN [1] {ECO:0000313|EMBL:EAL68740.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL68740.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=12097910; DOI=10.1038/nature00847;
RG Dictyostelium Genome Sequencing Consortium;
RA Glockner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2] {ECO:0000313|EMBL:EAL68740.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL68740.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=15875012; DOI=10.1038/nature03481;
RG The Dictyostelium discoideum Sequencing Consortium;
RA Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA Noegel A.A., Barrell B., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL68740.1}.
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DR EMBL; AAFI02000020; EAL68740.1; -; Genomic_DNA.
DR RefSeq; XP_642642.1; XM_637550.1.
DR AlphaFoldDB; Q54ZK0; -.
DR SMR; Q54ZK0; -.
DR PaxDb; 44689-DDB0217984; -.
DR GeneID; 8621058; -.
DR KEGG; ddi:DDB_G0277555; -.
DR dictyBase; DDB_G0277555; -.
DR eggNOG; KOG1225; Eukaryota.
DR HOGENOM; CLU_003793_0_0_1; -.
DR InParanoid; Q54ZK0; -.
DR PhylomeDB; Q54ZK0; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR24032:SF69; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24032; EGF-LIKE DOMAIN-CONTAINING PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF01833; TIG; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS00022; EGF_1; 2.
DR PROSITE; PS50026; EGF_3; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002195};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1113
FT /note="EGF-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004250068"
FT TRANSMEM 1034..1058
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 609..642
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 613..623
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 632..641
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1113 AA; 125537 MW; AB6CA4452B1C56E1 CRC64;
MKKSKSLIFY FFFIFFLSIQ VNSNELNKKE YDCLVNFLTN LGKISNVGKN EKTFEYEFCN
PFFVSLPTEI KCNQGSITYL DTVQSNISYI IKDELLCFDN INYFLLSNIN YDSAIFFNSF
PKSLNKVILT GTNLQFSKVT KDLQTLSISI ISQKIPTTLK FSWFYKTTQF ILSSTSFSSN
KTHSIAFEND LKDSEIWETN YFNIISLNLP KFNNVKGFVQ IELIEGYNQT SWSNIKEIGN
VTNIYIRTND LTEFPNDHLS NIRSDSIEKI NFEVPFKSVK KMCDLSSIGK SIQIISFSKC
GRDFSFNGLM PIILPNNQDF QYFFLIGGYI KNFDILQYKS AEYITLSNNL MSGTLPSINS
FKFGKLKYID IGFNLITGEL DDSYCEFDII VNNNSMTGLI PTCFTCFFGL TELNLKSRFI
GNNFTNLDQP SSPSIISPNL IFSNIEIFQG QPHYKYYIFG ENLGGAWIDE SNAEIIGFDV
KFRVIKPNKL ISLYSLSSFS SIVTFSYSRI NSNYRFTLSA DLITPKLIKV EWVSNSQDLA
FEGFYFSYNK SIINISIGDV NCQVTSSTFY NINCTLLAPI DLTLIDIVSF ITVGNLTTQF
TLNPGVTNNL LYCINGCGGN GICFSDIGKC KCDSTHQGDD CSLPYIECPI NCTNLSVCNN
VTGECSCPSF LIWSGIDCSF PLHTISAVSP SDINGGSASI YGWFGNIHND PQVFIGTKQC
IPIYNISESE IICKAPPGTG LKSVSVIQNS INVTSKDIYQ YYSNDKQCPN HCTSTSNGIC
NTTTGYCNCI GRWSGYDCSL YSNPSGGGDN SGGLPGSNTT IDGNTGNTNI TLIDFNGNQI
NEYLLLNKWS IISNISKTVY TFNQSIQNDK CNITYTIEEV NKDRDVSFAG INFKLTSGSV
KMTVSIENYQ YSSNLNTLQL QMKSSVNEIQ INHEMNDCNN DQIEINNTPN QYNSLNYITI
KKDAKVLNGR FIDRIESDGI STFMQTVLVS KSNDSITVGM NLPHCTKKCL LDPDFSVLVS
PEFVDECDND RKSFFLPVVI VVPIVFLILI IIFVVITIKK RYVEIIIINK NLINRIHFKK
FLNIFQTNPN IHFLFFKNKS TLKILKFVRP YTK
//
