ID Q55223_STRSQ Unreviewed; 418 AA.
AC Q55223;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1996, sequence version 1.
DT 08-NOV-2023, entry version 82.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:AAA87618.1};
GN Name=dauA {ECO:0000313|EMBL:AAA87618.1};
OS Streptomyces sp.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1931 {ECO:0000313|EMBL:AAA87618.1};
RN [1] {ECO:0000313|EMBL:AAA87618.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C5 {ECO:0000313|EMBL:AAA87618.1};
RX PubMed=7928998;
RA Ye J., Dickens M.L., Plater R., Li Y., Lawrence J., Strohl W.R.;
RT "Isolation and sequence analysis of polyketide synthase genes from the
RT daunomycin-producing Streptomyces sp. strain C5.";
RL J. Bacteriol. 176:6270-6280(1994).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467,
CC ECO:0000256|RuleBase:RU003694}.
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DR EMBL; L34880; AAA87618.1; -; Genomic_DNA.
DR AlphaFoldDB; Q55223; -.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00834; KAS_I_II; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR000794; Beta-ketoacyl_synthase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11712:SF336; 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11712; POLYKETIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Transferase {ECO:0000256|RuleBase:RU003694}.
FT DOMAIN 2..415
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 418 AA; 43741 MW; 80AFCA544FE439F7 CRC64;
MNRRVVITGM GVVAPGAIGI KSFWELLLSG TTATRAITTF DATPFRSRIA AECDFDPVAA
GLSAEQARRL DRAGQFALVA GQEALTDSGL RIGEDSAHRV GVCVGTAVGC TQKLESEYVA
LSAGGANWVV DPHRGAPELY DYFVPSSLAA EVAWLAGAEG PVNIVSAGCT SGIDSIGYAC
ELIREGTVDV MLAGGVDAPI APITVACFDA IRVTSDHNDT PETLAPFSRS RNGFVLGEGG
AIVVLEEAEA AVRRGARIYA EIGGYASRGN AYHMTGLRAD GAEMAAAITA ALDEARRDPS
DVDYVNAHGT ATRQNDRHET SAFKRSLGDH AYRVPISSVK SMIGHSLGAA GSLEVAATAL
AVEYGAIPPT ANLHDPDPEL DLDYVPLTAR EKRVRHALTV GSGFGGFQSA MLLSRPER
//
