ID IREA_DICDI Reviewed; 984 AA.
AC Q55GJ2;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 01-MAY-2013, entry version 62.
DE RecName: Full=Probable serine/threonine-protein kinase ireA;
DE EC=2.7.11.1;
DE AltName: Full=Inositol-requiring protein A;
DE Flags: Precursor;
GN Name=ireA; ORFNames=DDB_G0267650;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A.,
RA Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q.,
RA Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F.,
RA Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P.,
RA Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P.,
RA Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N.,
RA Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M.,
RA Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I.,
RA Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R.,
RA Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C.,
RA Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D.,
RA Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S.,
RA Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T.,
RA Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A.,
RA Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M.,
RA Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G.,
RA Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC protein (Potential).
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr
CC protein kinase family.
CC -!- SIMILARITY: Contains 1 KEN domain.
CC -!- SIMILARITY: Contains 1 protein kinase domain.
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DR EMBL; AAFI02000003; EAL73278.1; -; Genomic_DNA.
DR RefSeq; XP_647192.1; XM_642100.1.
DR ProteinModelPortal; Q55GJ2; -.
DR STRING; 44689.DDB_0231217; -.
DR EnsemblProtists; DDB0231217; DDB0231217; DDB_G0267650.
DR GeneID; 8615996; -.
DR KEGG; ddi:DDB_G0267650; -.
DR dictyBase; DDB_G0267650; ireA.
DR eggNOG; COG0515; -.
DR InParanoid; Q55GJ2; -.
DR KO; K08852; -.
DR OMA; DEFIYLA; -.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:dictyBase.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005635; C:nuclear envelope; ISS:dictyBase.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004521; F:endoribonuclease activity; ISS:dictyBase.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; ISS:dictyBase.
DR GO; GO:0006020; P:inositol metabolic process; ISS:dictyBase.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR InterPro; IPR010513; KEN_dom.
DR InterPro; IPR011009; Kinase-like_dom.
DR InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR InterPro; IPR000719; Prot_kinase_cat_dom.
DR InterPro; IPR006567; PUG-dom.
DR InterPro; IPR011047; Quinonprotein_ADH-like_supfam.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF06479; Ribonuc_2-5A; 1.
DR SMART; SM00564; PQQ; 3.
DR SMART; SM00580; PUG; 1.
DR SUPFAM; SSF56112; Kinase_like; 1.
DR SUPFAM; SSF50998; Quin_alc_DH_like; 1.
DR PROSITE; PS51392; KEN; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Complete proteome; Glycoprotein; Kinase;
KW Membrane; Nucleotide-binding; Reference proteome;
KW Serine/threonine-protein kinase; Signal; Transferase; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1 26 Potential.
FT CHAIN 27 984 Probable serine/threonine-protein kinase
FT ireA.
FT /FTId=PRO_0000362015.
FT TOPO_DOM 27 436 Extracellular (Potential).
FT TRANSMEM 437 457 Helical; (Potential).
FT TOPO_DOM 458 984 Cytoplasmic (Potential).
FT DOMAIN 575 851 Protein kinase.
FT DOMAIN 854 984 KEN.
FT NP_BIND 581 589 ATP (By similarity).
FT COILED 467 533 Potential.
FT COMPBIAS 356 398 Poly-Asn.
FT COMPBIAS 420 427 Poly-Asn.
FT COMPBIAS 467 488 Poly-Asn.
FT COMPBIAS 493 502 Poly-Lys.
FT COMPBIAS 538 546 Poly-Gln.
FT COMPBIAS 677 691 Poly-Asn.
FT ACT_SITE 722 722 Proton acceptor (By similarity).
FT BINDING 603 603 ATP (By similarity).
FT CARBOHYD 228 228 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 398 398 N-linked (GlcNAc...) (Potential).
SQ SEQUENCE 984 AA; 112801 MW; 2D8B3444AD001E87 CRC64;
MTFSKTRNKI IFLLFLIIIN IFNINAYIKD ENEDDLSLLI STLDGNIYSF NYESGELNWD
LKPNGGDSLY STSQFDRKQQ QSTSTSTEIT KSSPSILIPT LDGSGLLFQY SNDRLHQVPF
SLQELVNTSP LFLKELEDKS STSSTSTTSE SSKDENKVTM FIGNKKTSIT VVDSQTGEII
KSMSKDGLWL TDEDDCPVNI IPDEALMFTR SDYQIIALDP KSGVEKWNLS VGEYIPHSTK
SFYNSEISLN FEGLIEVASL SQRMYKIYIK KPEKTVVGIS HNYWEHILTS SPVSIYAYSS
KKHILKKLDF HRKVSPYSNS LIPVASTDLM IPSNFDRTFM FDDYYGQLFI VSPPSNNNNN
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNK NNNNNNKNES DKSNLTPLTP YDPSKPNGAN
NNNNNNNDLL DSNKLKNYDI YLYSSIVILI TSIIVFIRSK KNFNLINVNN NNNQNNNQNS
NQNNNINNKK TPKKKKKKQK NKNNKNNNDE DDENEIENYN DNQNDLIDEF ISTNSVIQQQ
QQQQQQLINS SNKINNGSGK IILDNGNVKI GKLEIITNKI LGTGSCGTIV YEGKMEGRKV
AVKRMLSQFV KFADREVSIL IHSDEHTNVV RYYAKEEDDE FIYLAISFCQ KSLDMYVQQT
LSLQISPTDS PSIQSSNNNG NGNNGNNNNN NQIIIDNKTK QMILELFKGL EHLHSLNIVH
RDIKPHNVLI DPNNRVKISD MGLGKLLDND DQSLTFTSDS HGWQPAEYLN GTNRNTKKVD
IFSLGCVVYY LLTGAHPFGH RYNREKNVLK GKFDIDQIKH LPDIHQLVHS MIQFEPEKRP
DIGECINHPF FWEVHKKLSF LVAASDYLEF EKPTSPLNLE IDSHVDLVTD GSGDWWLKID
QVLIDNIGRY RKYNGKSIRD LLRVIRNKFN HYRDLSPEEQ TCLGILPDGF FNYFDLKFPQ
LFIVTYLFIL KNLKNDQYFV QYYY
//
