GenomeNet

Database: UniProt
Entry: Q55GJ2
LinkDB: Q55GJ2
Original site: Q55GJ2 
ID   IREA_DICDI              Reviewed;         984 AA.
AC   Q55GJ2;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   16-APR-2014, entry version 67.
DE   RecName: Full=Probable serine/threonine-protein kinase ireA;
DE            EC=2.7.11.1;
DE   AltName: Full=Inositol-requiring protein A;
DE   Flags: Precursor;
GN   Name=ireA; ORFNames=DDB_G0267650;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A.,
RA   Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q.,
RA   Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F.,
RA   Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P.,
RA   Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P.,
RA   Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N.,
RA   Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M.,
RA   Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I.,
RA   Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R.,
RA   Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C.,
RA   Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D.,
RA   Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S.,
RA   Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T.,
RA   Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A.,
RA   Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M.,
RA   Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G.,
RA   Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein (Potential).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr
CC       protein kinase family.
CC   -!- SIMILARITY: Contains 1 KEN domain.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AAFI02000003; EAL73278.1; -; Genomic_DNA.
DR   ProteinModelPortal; Q55GJ2; -.
DR   STRING; 44689.DDB_0231217; -.
DR   EnsemblProtists; DDB0231217; DDB0231217; DDB_G0267650.
DR   KEGG; ddi:DDB_G0267650; -.
DR   dictyBase; DDB_G0267650; ireA.
DR   eggNOG; COG0515; -.
DR   InParanoid; Q55GJ2; -.
DR   KO; K08852; -.
DR   OMA; DEFIYLA; -.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:dictyBase.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005635; C:nuclear envelope; ISS:dictyBase.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004521; F:endoribonuclease activity; ISS:dictyBase.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; ISS:dictyBase.
DR   GO; GO:0006020; P:inositol metabolic process; ISS:dictyBase.
DR   GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR   GO; GO:0006468; P:protein phosphorylation; ISS:dictyBase.
DR   GO; GO:0090502; P:RNA phosphodiester bond hydrolysis, endonucleolytic; ISS:GOC.
DR   Gene3D; 2.140.10.10; -; 2.
DR   InterPro; IPR010513; KEN_dom.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR006567; PUG-dom.
DR   InterPro; IPR027295; Quinonprotein_ADH-like_fam.
DR   InterPro; IPR011047; Quinonprotein_ADH-like_supfam.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF06479; Ribonuc_2-5A; 1.
DR   SMART; SM00564; PQQ; 3.
DR   SMART; SM00580; PUG; 1.
DR   SUPFAM; SSF50998; SSF50998; 1.
DR   SUPFAM; SSF56112; SSF56112; 2.
DR   PROSITE; PS51392; KEN; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; Complete proteome; Glycoprotein; Kinase;
KW   Membrane; Nucleotide-binding; Reference proteome;
KW   Serine/threonine-protein kinase; Signal; Transferase; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL        1     26       Potential.
FT   CHAIN        27    984       Probable serine/threonine-protein kinase
FT                                ireA.
FT                                /FTId=PRO_0000362015.
FT   TOPO_DOM     27    436       Extracellular (Potential).
FT   TRANSMEM    437    457       Helical; (Potential).
FT   TOPO_DOM    458    984       Cytoplasmic (Potential).
FT   DOMAIN      575    851       Protein kinase.
FT   DOMAIN      854    984       KEN.
FT   NP_BIND     581    589       ATP (By similarity).
FT   COILED      467    533       Potential.
FT   COMPBIAS    356    398       Poly-Asn.
FT   COMPBIAS    420    427       Poly-Asn.
FT   COMPBIAS    467    488       Poly-Asn.
FT   COMPBIAS    493    502       Poly-Lys.
FT   COMPBIAS    538    546       Poly-Gln.
FT   COMPBIAS    677    691       Poly-Asn.
FT   ACT_SITE    722    722       Proton acceptor (By similarity).
FT   BINDING     603    603       ATP (By similarity).
FT   CARBOHYD    228    228       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    398    398       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   984 AA;  112801 MW;  2D8B3444AD001E87 CRC64;
     MTFSKTRNKI IFLLFLIIIN IFNINAYIKD ENEDDLSLLI STLDGNIYSF NYESGELNWD
     LKPNGGDSLY STSQFDRKQQ QSTSTSTEIT KSSPSILIPT LDGSGLLFQY SNDRLHQVPF
     SLQELVNTSP LFLKELEDKS STSSTSTTSE SSKDENKVTM FIGNKKTSIT VVDSQTGEII
     KSMSKDGLWL TDEDDCPVNI IPDEALMFTR SDYQIIALDP KSGVEKWNLS VGEYIPHSTK
     SFYNSEISLN FEGLIEVASL SQRMYKIYIK KPEKTVVGIS HNYWEHILTS SPVSIYAYSS
     KKHILKKLDF HRKVSPYSNS LIPVASTDLM IPSNFDRTFM FDDYYGQLFI VSPPSNNNNN
     NNNNNNNNNN NNNNNNNNNN NNNNNNNNNK NNNNNNKNES DKSNLTPLTP YDPSKPNGAN
     NNNNNNNDLL DSNKLKNYDI YLYSSIVILI TSIIVFIRSK KNFNLINVNN NNNQNNNQNS
     NQNNNINNKK TPKKKKKKQK NKNNKNNNDE DDENEIENYN DNQNDLIDEF ISTNSVIQQQ
     QQQQQQLINS SNKINNGSGK IILDNGNVKI GKLEIITNKI LGTGSCGTIV YEGKMEGRKV
     AVKRMLSQFV KFADREVSIL IHSDEHTNVV RYYAKEEDDE FIYLAISFCQ KSLDMYVQQT
     LSLQISPTDS PSIQSSNNNG NGNNGNNNNN NQIIIDNKTK QMILELFKGL EHLHSLNIVH
     RDIKPHNVLI DPNNRVKISD MGLGKLLDND DQSLTFTSDS HGWQPAEYLN GTNRNTKKVD
     IFSLGCVVYY LLTGAHPFGH RYNREKNVLK GKFDIDQIKH LPDIHQLVHS MIQFEPEKRP
     DIGECINHPF FWEVHKKLSF LVAASDYLEF EKPTSPLNLE IDSHVDLVTD GSGDWWLKID
     QVLIDNIGRY RKYNGKSIRD LLRVIRNKFN HYRDLSPEEQ TCLGILPDGF FNYFDLKFPQ
     LFIVTYLFIL KNLKNDQYFV QYYY
//
DBGET integrated database retrieval system