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Database: UniProt
Entry: Q56127
LinkDB: Q56127
Original site: Q56127 
ID   RCSB_SALTI              Reviewed;         216 AA.
AC   Q56127;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   01-OCT-2014, entry version 101.
DE   RecName: Full=Transcriptional regulatory protein RcsB {ECO:0000255|HAMAP-Rule:MF_00981};
GN   Name=rcsB {ECO:0000255|HAMAP-Rule:MF_00981};
GN   OrderedLocusNames=STY2495, t0595;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=8626298;
RA   Virlogeux I., Waxin H., Ecobichon C., Lee J.O., Popoff M.Y.;
RT   "Characterization of the rcsA and rcsB genes from Salmonella typhi:
RT   rcsB through tviA is involved in regulation of Vi antigen synthesis.";
RL   J. Bacteriol. 178:1691-1698(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=GIFU 10007;
RA   Hashimoto Y.;
RL   Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P.,
RA   Cronin A., Davis P., Davies R.M., Dowd L., White N., Farrar J.,
RA   Feltwell T., Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K.,
RA   Krogh A., Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C.,
RA   Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K.,
RA   Whitehead S., Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella
RT   enterica serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/JB.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J.,
RA   Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2
RT   and CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: Component of the Rcs signaling system, which controls
CC       transcription of numerous genes. RcsB is the response regulator
CC       that binds to regulatory DNA regions. Can function both in an
CC       RcsA-dependent or RcsA-independent manner. {ECO:0000255|HAMAP-
CC       Rule:MF_00981}.
CC   -!- SUBUNIT: Interacts with RcsD and RcsA. {ECO:0000255|HAMAP-
CC       Rule:MF_00981}.
CC   -!- PTM: Phosphorylated and activated by RcsD. {ECO:0000255|HAMAP-
CC       Rule:MF_00981}.
CC   -!- SIMILARITY: Belongs to the RcsB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00981}.
CC   -!- SIMILARITY: Contains 1 HTH luxR-type DNA-binding domain.
CC       {ECO:0000255|HAMAP-Rule:MF_00981}.
CC   -!- SIMILARITY: Contains 1 response regulatory domain.
CC       {ECO:0000255|HAMAP-Rule:MF_00981}.
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DR   EMBL; X87830; CAA61094.1; -; Genomic_DNA.
DR   EMBL; AB000683; BAA19163.1; -; Genomic_DNA.
DR   EMBL; AL513382; CAD07501.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO68300.1; -; Genomic_DNA.
DR   RefSeq; NP_456814.1; NC_003198.1.
DR   RefSeq; NP_804451.1; NC_004631.1.
DR   ProteinModelPortal; Q56127; -.
DR   SMR; Q56127; 129-215.
DR   STRING; 220341.STY2495; -.
DR   PRIDE; Q56127; -.
DR   EnsemblBacteria; AAO68300; AAO68300; t0595.
DR   EnsemblBacteria; CAD07501; CAD07501; CAD07501.
DR   GeneID; 1248824; -.
DR   KEGG; sty:STY2495; -.
DR   PATRIC; 18542957; VBISalEnt120419_2527.
DR   eggNOG; COG2197; -.
DR   HOGENOM; HOG000034813; -.
DR   KO; K07687; -.
DR   OMA; QKKSAMT; -.
DR   OrthoDB; EOG69GZGV; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_00981; RcsB; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR011991; WHTH_DNA-bd_dom.
DR   Pfam; PF00196; GerE; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS00622; HTH_LUXR_1; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Complete proteome; DNA-binding; Phosphoprotein; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN         1    216       Transcriptional regulatory protein RcsB.
FT                                /FTId=PRO_0000081212.
FT   DOMAIN        5    124       Response regulatory. {ECO:0000255|HAMAP-
FT                                Rule:MF_00981}.
FT   DOMAIN      144    209       HTH luxR-type. {ECO:0000255|HAMAP-
FT                                Rule:MF_00981}.
FT   DNA_BIND    168    187       H-T-H motif. {ECO:0000255|HAMAP-
FT                                Rule:MF_00981}.
FT   MOD_RES      56     56       4-aspartylphosphate. {ECO:0000255|HAMAP-
FT                                Rule:MF_00981}.
SQ   SEQUENCE   216 AA;  23729 MW;  D35CE2AB2B1DC0E4 CRC64;
     MNNMNIIIAD DHPIVLFGIR KSLEQIEWVN VVGEFEDSTA LINNLPKLDA HVLITDLSMP
     GDKYGDGITL IKYIKRHFPS LSIIVLTMNN NPAILSAVLD LDIEGIVLKQ GAPTDLPKAL
     AALQKGKKFT PESVSRLLEK ISAGGYGDKR LSPKESEVLR LFAEGFLVTE IAKKLNRSIK
     TISSQKKSAM MKLGVENDIA LLNYLSSVTL SPTDKE
//
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