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Database: UniProt
Entry: Q562E3_MOUSE
LinkDB: Q562E3_MOUSE
Original site: Q562E3_MOUSE 
ID   Q562E3_MOUSE            Unreviewed;       504 AA.
AC   Q562E3;
DT   10-MAY-2005, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2005, sequence version 1.
DT   08-NOV-2023, entry version 90.
DE   SubName: Full=Rapgef6 protein {ECO:0000313|EMBL:AAH92525.1};
DE   Flags: Fragment;
GN   Name=Rapgef6 {ECO:0000313|EMBL:AAH92525.1,
GN   ECO:0000313|MGI:MGI:2384761};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH92525.1};
RN   [1] {ECO:0000313|EMBL:AAH92525.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6 {ECO:0000313|EMBL:AAH92525.1};
RC   TISSUE=Eye {ECO:0000313|EMBL:AAH92525.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
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DR   EMBL; BC092525; AAH92525.1; -; mRNA.
DR   AlphaFoldDB; Q562E3; -.
DR   PeptideAtlas; Q562E3; -.
DR   AGR; MGI:2384761; -.
DR   MGI; MGI:2384761; Rapgef6.
DR   ChiTaRS; Rapgef6; mouse.
DR   GO; GO:0016324; C:apical plasma membrane; ISO:MGI.
DR   GO; GO:0005813; C:centrosome; ISO:MGI.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0030139; C:endocytic vesicle; ISO:MGI.
DR   GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR   GO; GO:0030742; F:GTP-dependent protein binding; ISO:MGI.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISO:MGI.
DR   GO; GO:0070300; F:phosphatidic acid binding; ISO:MGI.
DR   GO; GO:0031267; F:small GTPase binding; ISO:MGI.
DR   GO; GO:0030033; P:microvillus assembly; ISO:MGI.
DR   GO; GO:0072659; P:protein localization to plasma membrane; ISO:MGI.
DR   GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR   CDD; cd01785; RA_PDZ-GEF1; 1.
DR   CDD; cd00155; RasGEF; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF222; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
PE   2: Evidence at transcript level;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168}.
FT   DOMAIN          6..92
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   DOMAIN          117..345
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          452..474
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAH92525.1"
SQ   SEQUENCE   504 AA;  57457 MW;  8A4F554CBE8D6257 CRC64;
     NPSDIPDQVI RVFKADQQSC YIIISKDTTA KEVVCQAVQE FGLTGASDTY SLCEVSVTPE
     GVIKQRRLPD QFSKLADRIQ LNGRYYLKNN METETLCSDE DAQELLKESQ LSMLQLSTIE
     VATQLSMRDF DLFRNIEPTE YIDDLFKLDS KTGNTHLKQF EDIVNQETFW VASEILSESN
     QLKRMKIIKH FIKIALHCRE CKNFNSMFAI ISGLNLAPVA RLRGTWEKLP SKYEKHLQDL
     QDLFDPSRNM AKYRNILSSQ SMQPPIIPLF PVVKKDMTFL HEGNDSKVDG LVNFEKLRMI
     AKEIRHIIRM TSANMDPAMM FRQRSLSQGS TNSNMLDVQG GAHKKRARRS SLLNAKKLYE
     DAQMARKVKQ YLSSLDIDTD EEKFQMMSLQ WEPAYGTLTK NLTEKRSAKS SEMSPVPLRS
     VGQTAKVHLH QPHRVSQVLQ VPAVNLHPIR KKGQAKDHVL STSLPQKGLG PTEEVSVKKH
     TEDTISVASS LHSSPLLQDI WEFL
//
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