ID ZN608_MOUSE Reviewed; 1511 AA.
AC Q56A10; Q6ZPU8; Q8BIG5; Q8BJ06;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 1.
DT 03-APR-2013, entry version 54.
DE RecName: Full=Zinc finger protein 608;
GN Name=Znf608; Synonyms=Kiaa1281, Zfp608;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 861-1511 (ISOFORM 1), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6, and FVB/N-3; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1260-1511 (ISOFORM 2).
RC TISSUE=Embryonic tail;
RX PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene:
RT III. The complete nucleotide sequences of 500 mouse KIAA-homologous
RT cDNAs identified by screening of terminal sequences of cDNA clones
RT randomly sampled from size-fractionated libraries.";
RL DNA Res. 10:167-180(2003).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q56A10-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q56A10-2; Sequence=VSP_023667, VSP_023668;
CC Note=No experimental confirmation available;
CC Name=3;
CC IsoId=Q56A10-3; Sequence=VSP_023665, VSP_023666;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Contains 1 C2H2-type zinc finger.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC36234.1; Type=Erroneous initiation;
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DR EMBL; AK047979; BAC33204.1; -; mRNA.
DR EMBL; AK076178; BAC36234.1; ALT_INIT; mRNA.
DR EMBL; BC092219; AAH92219.1; -; mRNA.
DR EMBL; AK129321; BAC98131.1; -; mRNA.
DR IPI; IPI00460711; -.
DR IPI; IPI00469437; -.
DR IPI; IPI00830242; -.
DR RefSeq; NP_786927.2; NM_175751.4.
DR UniGene; Mm.192984; -.
DR UniGene; Mm.471753; -.
DR ProteinModelPortal; Q56A10; -.
DR PhosphoSite; Q56A10; -.
DR PaxDb; Q56A10; -.
DR PRIDE; Q56A10; -.
DR Ensembl; ENSMUST00000064763; ENSMUSP00000068192; ENSMUSG00000052713.
DR GeneID; 269023; -.
DR KEGG; mmu:269023; -.
DR UCSC; uc008eyg.1; mouse.
DR CTD; 269023; -.
DR MGI; MGI:2442338; Zfp608.
DR eggNOG; NOG86608; -.
DR GeneTree; ENSGT00390000008748; -.
DR HOGENOM; HOG000082539; -.
DR HOVERGEN; HBG054557; -.
DR InParanoid; Q56A10; -.
DR OMA; VSPVLMH; -.
DR OrthoDB; EOG4PRSPV; -.
DR NextBio; 392648; -.
DR ArrayExpress; Q56A10; -.
DR Bgee; Q56A10; -.
DR CleanEx; MM_ZFP608; -.
DR Genevestigator; Q56A10; -.
DR GO; GO:0005622; C:intracellular; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR SMART; SM00355; ZnF_C2H2; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; FALSE_NEG.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Complete proteome; Metal-binding;
KW Phosphoprotein; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1 1511 Zinc finger protein 608.
FT /FTId=PRO_0000280421.
FT ZN_FING 552 577 C2H2-type.
FT COILED 277 303 Potential.
FT COMPBIAS 140 263 Gly-rich.
FT COMPBIAS 309 314 Poly-Pro.
FT COMPBIAS 440 443 Poly-Ala.
FT MOD_RES 781 781 Phosphoserine (By similarity).
FT MOD_RES 963 963 Phosphoserine (By similarity).
FT VAR_SEQ 388 423 VLVVNVTWRNKTYVGTLLDCTKHDWAPPRFCESPTS -> K
FT YVLFLFISLCPLLHDVSLSICEGNLFSLWFERIER (in
FT isoform 3).
FT /FTId=VSP_023665.
FT VAR_SEQ 424 1511 Missing (in isoform 3).
FT /FTId=VSP_023666.
FT VAR_SEQ 1432 1455 PVEKASTEREREAERERDRHSPFS -> VSLLLLVVKRPCL
FT VGEGRQETEQS (in isoform 2).
FT /FTId=VSP_023667.
FT VAR_SEQ 1456 1511 Missing (in isoform 2).
FT /FTId=VSP_023668.
FT CONFLICT 931 932 AK -> PN (in Ref. 1; BAC36234).
FT CONFLICT 987 987 Q -> H (in Ref. 1; BAC36234).
FT CONFLICT 1039 1039 K -> N (in Ref. 1; BAC36234).
FT CONFLICT 1436 1436 A -> G (in Ref. 1; BAC36234).
FT CONFLICT 1449 1449 D -> G (in Ref. 1; BAC36234).
FT CONFLICT 1490 1490 V -> G (in Ref. 1; BAC36234).
SQ SEQUENCE 1511 AA; 162345 MW; 4331F1298053D5AC CRC64;
MSVNVSTAGK GVDPNTVDTY DSGDDWEIGV GNLIIDLDAD LEKDRQKFEM NNSTNTTTNT
TKDCGGPASN GTCSTSALAD GLKFASVQPS APQGNSHKET SKSKVKRAKT SKDANKSLPS
AALYGIPEIS STGKRQEVQG RPGEATGMNS ALGQSVSGGG SSNPNSNGTS TGTSAATAGA
GSCGKSKEEK PGKSHSSRGA KRDKDAARSR KEKHDLLQGH QNGGGGQAPS GGHLYGFGTK
SNGSGASPFH CGGAGSGSVG AAGEVSKTAP DSTLMGNSML VKKEEEEEES HRRIKKLKTE
KVDPLFTVPA PPPPIASSLA PQIPPSYFPP SSSNIAAPVE QLLVRTRSVG VNTCEVGVVT
EPECLGPCEP GTSVNLEGIV WHETEEGVLV VNVTWRNKTY VGTLLDCTKH DWAPPRFCES
PTSDLEMRGG RGRGKRARSA AAAPGSEVSF TESRGLQSKN RGGANGKGRR GSLNASGRRT
PPNCAAEDIK ASPSSTNKRK NKPPMELDLN SSSEDSKPGK RVRTNSRSTP TTPQGKPETT
FLDQGCSSPV LIDCPHPNCN KKYKHINGLR YHQAHAHLDP ENKLEFEPDS EDKISDCEEA
LSNVALECNE SSTSVSSYDQ TKAPGSPGAG NPPGTPKGKR EHVSNGPGPI IGSKTGKNSG
KKRGLNNELN NLPVISNMTA ALDICSATDS NLTAEMPKLE AEGLIDKKSL GDKEKGKKAN
NCKMDKNLSK LKSARPIAPA PAPTPPQLIA IPTAAFTSTT TGTIPGLPSL TTTVVQATPK
SPPLKPIQPK PTIMGEPITV NPALVSLKDR KKKEKRKLKD KEGKETGGPK MDAKLGKLEE
AKAASKDLSG HFLKDHLGKS EGLANGLSES QESRMASIKA EADKVYTFTD NAPSPSIGSA
SRMECSTLVN GQAPMAPLHV LTQNGAESAA AKTSSPAYSD ISDAADDGGS DSRSEGMRSK
ASSPSDTFSN KDGVVKGHPS TSAQPSQLKE SHSPYYHGYE PYYSPSYMHP GQVGAPAAGN
GGSTQGMKIK KESEEDAEKK DKAEQLESKK VDHTSAPLQP QHQSVITQRH PALAQSLYYG
QYAYGLYMDQ KSLMATSPAY RQQYEKYYED QRLAEQKMAQ SGRGDCERKA ELPLKELGKE
DNKQKNMPSA TISKAPSTPE PNKNHSKLGP SVPNKTEETG KSQLLSSHQQ QLQADSFKAK
QMENHQLIKE AVEMKSVMDS MKQTGVDPTS RFKQDPESRT WHHYVYQPKY LDQQKPEELD
REKKLKEDSP RKTPNKESGV SSLPVSLTNI KEEPKEGKRP DSQSVEENKL KNDDRKTPVN
WKDSRGTRVA VSSPMSQHQS YIQYLHAYPY PQMYDPSHPA YRAVSPVLMH SYPGAYLSPG
FHYPVYGKMS GREEAEKVNT SPSINTKTAS EAKALDLLQH HANQYRSKSP APVEKASTER
EREAERERDR HSPFSQRHLH THHHTHVGMG YPLIPGQYDP FQGLTSAALV ASQQVAAQAS
ASGMFPAQRR E
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