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Database: UniProt
Entry: Q56I99
LinkDB: Q56I99
Original site: Q56I99 
ID   SMAD5_CHICK             Reviewed;         465 AA.
AC   Q56I99;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   16-APR-2014, entry version 65.
DE   RecName: Full=Mothers against decapentaplegic homolog 5;
DE            Short=MAD homolog 5;
DE            Short=Mothers against DPP homolog 5;
DE   AltName: Full=SMAD family member 5;
DE            Short=SMAD 5;
DE            Short=Smad5;
GN   Name=SMAD5; Synonyms=MADH5;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Testudines + Archosauria group; Archosauria; Dinosauria; Saurischia;
OC   Theropoda; Coelurosauria; Aves; Neognathae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Ovary;
RA   Li J., Wang Y., Hon C., Wong E.W., Leung F.C.;
RT   "Cloning of Smad 1, Smad5 and Smad8 from the chicken ovary and
RT   characterization of their expression during chicken ovarian
RT   development.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional modulator activated by BMP (bone
CC       morphogenetic proteins) type 1 receptor kinase. SMAD5 is a
CC       receptor-regulated SMAD (R-SMAD) (By similarity).
CC   -!- SUBUNIT: May form trimers with the co-SMAD SMAD4 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By
CC       similarity). Note=Cytoplasmic in the absence of ligand. Migrates
CC       to the nucleus when complexed with SMAD4 (By similarity).
CC   -!- SIMILARITY: Belongs to the dwarfin/SMAD family.
CC   -!- SIMILARITY: Contains 1 MH1 (MAD homology 1) domain.
CC   -!- SIMILARITY: Contains 1 MH2 (MAD homology 2) domain.
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DR   EMBL; AY953144; AAX56945.1; -; mRNA.
DR   RefSeq; NP_001014968.1; NM_001014968.1.
DR   UniGene; Gga.44385; -.
DR   UniGene; Gga.50148; -.
DR   ProteinModelPortal; Q56I99; -.
DR   SMR; Q56I99; 10-133, 268-465.
DR   STRING; 9031.ENSGALP00000039387; -.
DR   PaxDb; Q56I99; -.
DR   Ensembl; ENSGALT00000040187; ENSGALP00000039387; ENSGALG00000006309.
DR   GeneID; 395679; -.
DR   KEGG; gga:395679; -.
DR   CTD; 4090; -.
DR   eggNOG; NOG330956; -.
DR   GeneTree; ENSGT00600000084186; -.
DR   HOGENOM; HOG000286018; -.
DR   HOVERGEN; HBG053353; -.
DR   InParanoid; Q56I99; -.
DR   KO; K16790; -.
DR   PhylomeDB; Q56I99; -.
DR   NextBio; 20815751; -.
DR   PRO; PR:Q56I99; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005667; C:transcription factor complex; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0060348; P:bone development; IEA:Ensembl.
DR   GO; GO:0060048; P:cardiac muscle contraction; IEA:Ensembl.
DR   GO; GO:0051216; P:cartilage development; IEA:Ensembl.
DR   GO; GO:0071773; P:cellular response to BMP stimulus; IEA:Ensembl.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0030218; P:erythrocyte differentiation; IEA:Ensembl.
DR   GO; GO:0007281; P:germ cell development; IEA:Ensembl.
DR   GO; GO:0002051; P:osteoblast fate commitment; IEA:Ensembl.
DR   GO; GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Ensembl.
DR   GO; GO:1901522; P:positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; IEA:Ensembl.
DR   GO; GO:0006468; P:protein phosphorylation; IEA:Ensembl.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0001657; P:ureteric bud development; IEA:Ensembl.
DR   Gene3D; 2.60.200.10; -; 1.
DR   Gene3D; 3.90.520.10; -; 1.
DR   InterPro; IPR013790; Dwarfin.
DR   InterPro; IPR003619; MAD_homology1_Dwarfin-type.
DR   InterPro; IPR013019; MAD_homology_MH1.
DR   InterPro; IPR017855; SMAD_dom-like.
DR   InterPro; IPR001132; SMAD_dom_Dwarfin-type.
DR   InterPro; IPR008984; SMAD_FHA_domain.
DR   PANTHER; PTHR13703; PTHR13703; 1.
DR   Pfam; PF03165; MH1; 1.
DR   Pfam; PF03166; MH2; 1.
DR   SMART; SM00523; DWA; 1.
DR   SMART; SM00524; DWB; 1.
DR   SUPFAM; SSF49879; SSF49879; 1.
DR   SUPFAM; SSF56366; SSF56366; 1.
DR   PROSITE; PS51075; MH1; 1.
DR   PROSITE; PS51076; MH2; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytoplasm; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc.
FT   CHAIN         1    465       Mothers against decapentaplegic homolog
FT                                5.
FT                                /FTId=PRO_0000291877.
FT   DOMAIN       13    137       MH1.
FT   DOMAIN      271    465       MH2.
FT   COMPBIAS     40     46       Poly-Lys.
FT   METAL        65     65       Zinc (By similarity).
FT   METAL       110    110       Zinc (By similarity).
FT   METAL       122    122       Zinc (By similarity).
FT   METAL       127    127       Zinc (By similarity).
SQ   SEQUENCE   465 AA;  52228 MW;  FC7FA32ABF016642 CRC64;
     MTSMASLFSF TSPAVKRLLG WKQGDEEEKW AEKAVDALVK KLKKKKGAME ELEKALSSPG
     QPSKCVTIPR SLDGRLQVSH RKGLPHVIYC RVWRWPDLQS HHELKPLDIC EFPFGSKQKE
     VCINPYHYKR VESPVLPPVL VPRHSEFNPQ HSLLVQFRNL SHNEPHMPHN ATFPDSFQQP
     NSTPFSISPN SPYPPSPASS TYPSSPASSG PSSPFQLPAD TPPPAYMPPD DQMGQDNSQS
     MDTSNTMIPQ IMPNISTRDV QPVAYEEPKH WCSIVYYELN NRVGEAFHAS STSVLVDGFT
     DPSNNKNRFC LGLLSNVNRN STIENTRRHI GKGVHLYYVG GEVYAECLSD SSIFVQSRNC
     NYHHGFHPTT VCKIPSGCSL KIFNNQEFAQ LLAQSVNHGF EAVYELTKMC TIRMSFVKGW
     GAEYHRQDVT STPCWIEIHL HGPLQWLDKV LTQMGSPLNP ISSVS
//
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